Bosch Institute
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Honours projects available in 2009 - by Theme

Cancer, cell biology & development
Stephen AssinderProstate cancer and benign prostatic hyperplasia
Maria ByrneBiology of fertilisation and early development of embryos
Kellie CharlesTargeting tumour-macrophage interactions
Rachel Codd
  1. Novel histone deacetylase inhibitors
  2. Capture of bacterial secondary metabolites
  3. Mechanisms of iron uptake in antarctic bacteria
  4. Selective capture of bleomycis streptomyces verticillus
Nicholas Cole
  1. Embryonic origins of vertebrate muscle
  2. Determining the position and timing of limb initiation
David I Cook
  1. Use of replication-deficient adenoviruses and retroviruses to investigate control of epithelial sodium channels in epithelia
  2. Identification of novel regulators of sodium channels
  3. Use of replication-deficient adenoviruses to investigate regulation of cytosolic calcium
  4. Characterisation of ClC family chloride channels in salivary and other epithelia
  5. Investigation of the role of sodium-bicarbonate cotransport in early embryonic development
Margot DayImpact of growth factors on early embryo development in vitro
Qihan DongArachidonic acid pathway in prostate cancer
Frank Lovicu
  1. Normal lens biology
  2. Lens pathology (cataract)
Rebecca S Mason
  1. Role of vitamin D and other compounds in the protection of skin cells from UV
  2. Muscle as a storage site for vitamin D
Chris MurphyFemale reproduction and structural cell biology
Chris O'Neill
  1. Reproduction
  2. Development
  3. Stem cells
  4. Cancer
Juergen ReichardtHuman molecular genetics of cancer and atherosclerosis
Des Richardson
  1. Development of new iron chelators as novel drugs against cancer
  2. Transport of nitric oxide in cells and its interaction with iron containing proteins in tumour cells
  3. The function of the malignant melanoma tumour antigen, melanotransferrin (p97), in tumourigenesis
  4. The role of iron in the pathogenesis of the crippling neurodegenerative disease, Friedreich's ataxia
Cardiovascular
Stuart Cordwell
  1. Peptide biomarkers of myocardial ischemia
  2. The role of calcium overload in myocardial I/R injury
Brian Morris
  1. Mechanisms of longevity
  2. Pre-mRNA splicing
Roland Stocker
  1. Unravelling the function of heme oxygenase-1 using a genetic approach and Biochemistry
  2. Role of cytochrome b5 in the reductive activation of indoleamine 2,3-dioxygenase
  3. Regulating vascular cells: Induction of Apoptosis by Heme oxygenase-1
  4. Contribution of indoleamine 2,3-dioxygenase to the regulation of vascular tone
  5. Antioxidant drugs as novel treatments for diabetes and atherosclerosis associated with diabetes
  6. Unravelling the molecular mechanism behind heme oxygenase 1 induced adaptive response.
Paul WittingPost translational changes to key cardiac proteins in the hearts of diabetic rats after experimental heart attack
Infection, immunity & inflammation
Bob Bao
  1. Sudden Death in Young Australian CSI (Sydney)
  2. Inflammatory bowel disease (IBD)
Georges Emile Raymond Grau
  1. Assessing microparticles as effectors in the microvascular lesion of cerebral malaria
  2. Investigating mechanisms of microparticle production by microvascular endothelial cells and defining clinically useful inhibitors.
  3. Defining the implication of hypoxia in the pathology of cerebral malaria
  4. Determining the interactions of MP with their target cells in the host
  5. Defining intracellular signalling pathways of microvascular endothelium stimulation by parasite and host cells
  6. Dissecting the molecular mechanisms of platelet-endothelial interactions
Nicholas Hunt
  1. Understanding a key new enzyme in the kynurenine pathway
  2. What causes death and disability in bacterial meningitis?
  3. How does an anti-inflammatory steroid reduce the lung oedema caused by malaria?
Nicholas King
  1. Changes in gene expression in neurons and microglia in WNV encephalitis
  2. Infiltrating leukocytes in WNV encephalitis - their role in mortality
  3. The role of mucosal dendritic cells in controlling virus infection in epithelium
  4. Why isn't the foreign embryo rejected by the mother's role of adhesion molecules.
  5. The role of monocyte/dendritic cells in initiating WNV immune responses.
  6. The role of microparticles in the immune response to WNV
Lyn MoirPulmonary lymphangioleiomyomatosis (LAM)
Brian Oliver
  1. How different are fibroblasts from various lung diseases?
  2. Can the common cold virus kill you?
  3. Can viruses stop b2-agonists from working?
  4. Does Tumstain regulate inflammation asthma?
Nervous system, senses & movement
Metabolomics of mental disease: effects of neuroleptics on brain metabolome.
Haydn AllbuttThe cause of all "neurodegenerative" diseases
David G Allen
  1. Muscle fatigue
  2. Pacemaker function in the heart
Jonathon ArnoldWhy cannabis use promotes psychotic relapse
Vladimir BalcarMetabolomics of mental disease: effects of clozapine on brain metabolome
Max Bennett
  1. The cellular origins of neuropathic pain: glial cells, macrophages and cytokines
  2. The cellular origins of migraine pain: astrocyte spreading depression
  3. The cellular origins of central pain sensitisation I: the astrocyte - microglia network
  4. The cellular origins of central pain sensitisation II: astrocytes, microglia and cytokines
  5. Pain representation in the brain: the astrocytic model for fMRI and the interpretation of images
Simon Carlile
  1. Perception of stationary and moving sound sources
  2. Neural and bioacoustical studies of the mammalian auditory system (guinea pig and ferret)
Karen Cullen
  1. Immunohistochemical study of the microvasculature and inflammation in Alzheimer's Disease brain tissue
  2. Inflammation and Microvasculature
  3. Pathogenesis of motor neuron disease
  4. Pathogenesis of motor neuron disease
  5. Chronological development of cytoskeletal abnormalities in the Alzheimer's Disease brain
  6. Chronological development of cytoskeletal abnormalities in the Alzheimer's Disease brain
Roger DampneyHypothalamic control of cardiovascular function
Denise DonlonDiscriminating between human and non-human bones as well as finding methods to identify ways of determining ancestry, sex, age and stature.
Bogdan DreherFunctional organisation of the visual system
Michelle Gerke‘peripheral’ nociceptors and ‘central’ glial cells to the development of chronic neuropathic pain states
Claire GoldsburyOxidative-stress and mitochondrial dysfunction in the initiation of Alzheimer-like cytoskeletal abnormalities
Brett HamblyProtein defects causing familial hypertrophic cardiomyopathy
Luke Henderson
  1. Brain changes associated with chronic pain in humans
  2. Brain changes associated with chronic pain in humans
Kevin KeayInjury, disability and chronic pain research
Christine Koeppl
  1. Evolution of the cochlear efferent system
  2. The basis of fast temporal processing in the cochlea of the barn owl
Jillian KrilThe substrate of memory impairment in Frontotemporal dementia (FTD)
Catherine LeameyDevelopment and plasticity of the nervous system
Bronwyn McAllan
  1. The regulation of reproductive physiology by environmental photoperiod
  2. The regulation of reproduction and metabolism by photoperiod and temperature
Roger PamphlettBrain mutations in Amyotrophic Lateral Sclerosis
William Phillips
  1. Protein kinase signaling at the neuromuscular junction
  2. Agrin, exercise and the aging neuromuscular junction
Dario Protti
  1. Contrast adaptation
  2. Plasticity phenomena in the nervous system
Atomu Sawatari
  1. The role of enrichment on the development of the hippocampus
  2. The importance of Ten_m3 in the wiring of cortico-striatal circuits
  3. The role of enrichment on the development of the retina
  4. Reversing the maturation of the hippocampus
Samuel Solomon
  1. Processing of motion by visual cortex
  2. Large scale activity of neurons in visual cortex
Jonathan StoneStability of the central nervous system and degenerative diseases of the retina (retinitis pigmentosa) and brain (dementia)
Robert Vandenberg
  1. Molecular Basis for K+ coupling of Glutamate Transporters
  2. Characterization of Drug Binding sites on Glycine Transporters
Bing YuGene copy number in sporadic Amyotrophic Lateral Sclerosis
Organ & tissue replacement
Reproductive biology and medicine
Alex Bishop
  1. Role of antibodies in liver transplant rejection
  2. Role of IL-4 in liver transplant tolerance
Tailoi Chan-LingThe retina in developmental neurobiology and neuropathology
Nicholas Cole
  1. Embryonic origins of vertebrate muscle
  2. Determining the position and timing of limb initiation
Michael MorrisEmbryonic stem cell
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