Associate Professor Qihan Dong

E:  qihan.dong@bosch.org.au T:  +61 2 9515 5186 F:  +61 2 9516 1273 D06 - Blackburn Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Niknami, M, Vignarajan, S, Yao, M, Hua, S, Witting, P, Kita, Y, Shimizu, T, Sved, P, Patel, M, Dong, Q. Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochimica et biophysica acta. 2010; 1801:731-7

Singh, J, Xie, C, Yao, M, Hua, S, Vignarajan, S, Jardine, G, Hambly, B, Sved, P, Dong, Q. Food extracts consumed in Mediterranean countries and East Asia reduce protein concentrations of androgen receptor, phospho-protein kinase B, and phospho-cytosolic phospholipase A(2)alpha in human prostate cancer cells. The Journal of nutrition. 2010; 140:786-91

Scott, K, Sajinovic, M, Hein, J, Nixdorf, S, Galettis, P, Liauw, W, de Souza, P, Dong, Q, Graham, G, Russell, P. Emerging roles for phospholipase A(2) enzymes in cancer. Biochimie. 2010; :

Assinder, S, Au, E, Dong, Q, Winnick, C. A novel splice variant of the beta-tropomyosin (TPM2) gene in prostate cancer. Molecular carcinogenesis. 2010; :

Yao, M, Taylor, R, Richards, M, Sved, P, Wong, J, Eisinger, D, Xie, C, Salomon, R, Risbridger, G, Dong, Q. Prostate-Regenerating Capacity of Cultured Human Adult Prostate Epithelial Cells. Cells, tissues, organs. 2010; 191:203-12

2009

Niknami, M, Dong, Q, Witting, P. Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. Free radical research. 2009; 43:951-6

Richards, A, McGeechan, K, Niknam, M, Salomon, R, Kurek, C, Dong, Q, Patel, M. Prolonging androgen sensitivity in prostate cancer - a role for COX inhibitors?. ANZ Journal of Surgery. 2009; 79:641-647

Salomon, R, Young, L, Macleod, D, Yu, X, Dong, Q. Probasin promoter-driven expression of ID1 is not sufficient for carcinogenesis in rodent prostate. Journal of Histochemistry and Cytochemistry. 2009; 57:599-604

Niknami, M, Patel, M, Witting, P, Dong, Q. Molecules in focus: Cytosolic phospholipase A(2)-alpha. The international journal of biochemistry & cell biology. 2009; 41:994-7

Assinder, S, Dong, Q, Mangs, H, Richardson, D. Pharmacological Targeting of the Integrated AKT, PTEN and TGF-{beta} Pathways in Prostate Cancer. Molecular pharmacology. 2009; 75:429-36

Assinder, S, Dong, Q, Kovacevic, Z, Richardson, D. The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochemical Journal. 2009; 417:411-421

2008

Patel, M, Singh, J, Niknami, M, Kurek, C, Yao, M, Lu, S, Maclean, F, King, N, Gelb, M, Scott, K, Russell, P, Boulas, J, Dong, Q. Cytosolic Phospholipase A2-{alpha}: A Potential Therapeutic Target for Prostate Cancer. Clinical Cancer Research. 2008; 14:8070-8079

Patel, M, Kurek, C, Dong, Q. The arachidonic acid pathway and its role in prostate cancer development and progression. The Journal of Urology. 2008; 179:1668-1675

Nikinami, M, Patel, M, Witting, P, Dong, Q. Aberrant activation of arachidonic acid and eicosanoid pathways-targets for treating prostate cancer. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2008; 2:9-15

2006

Lim, W, Tan, B, Zhu, Y, Zhou, S, Armstrong, J, Li, Q, Dong, Q, Chan, E, Smith, D, Verma, C, Tan, S, Duan, W. The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling. Cellular signalling. 2006; 18:1473-81

Dong, Q, Patel, M, Scott, K, Graham, G, Russell, P, Sved, P. Oncogenic action of phospholipase A(2) in prostate cancer. Cancer letters. 2006; 240:9-16

Singh, J, Manickam, P, Shmoish, M, Natik, S, Denyer, G, Handelsman, D, Gong, D, Dong, Q. Annotation of androgen dependence to human prostate cancer-associated genes by microarray analysis of mouse prostate. Cancer letters. 2006; 237:298-304

Young, L, Salomon, R, Au, W, Allan, C, Russell, P, Dong, Q. Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice. The Journal of Histochemistry and Cytochemistry. 2006; 54:223-229

2005

Zhu, Y, Dong, Q, Tan, B, Lim, W, Zhou, S, Duan, W. The PKC alpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals. Cancer Research. 2005; 65:4520-4524

Patel, M, Tuckerman, R, Dong, Q. A Pitfall of the 3-(4,5-dimethylthiazol-2-yl)-5(3-carboxymethonyphenol)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay due to evaporation in wells on the edge of a 96 well plate. Biotechnology letters. 2005; 27:805-8

Young, L, Dong, Q. Development of a murine prostatespecific 2-in-1 inducible bicistronic expression vector. Biotechnology letters. 2005; 27:823-8

Singh, J, Young, L, Handelsman, D, Dong, Q. Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium. Gene. 2005; 348:55-63

2004

Sved, P, Scott, K, McLeod, D, King, N, Singh, J, Tsatralis, T, Nikolov, B, Boulas, J, Nallan, L, Gelb, M, Sajinovic, M, Graham, G, Russell, P, Dong, Q. Oncogenic action of secreted phospholipase A2 in prostate cancer. Cancer research. 2004; 64:6934-40

Young, L, Dong, Q. Two-step total gene synthesis method. Nucleic acids research. 2004; 32:e59

2003

Young, L, Dong, Q. TAMS technology for simple and efficient in vitro site-directed mutagenesis and mutant screening. Nucleic acids research. 2003; 31:e11

2002

Singh, J, Young, L, Handelsman, D, Dong, Q. Prostate epithelial expression of a novel androgen target gene. Journal of andrology. 2002; 23:652-60

2001

Chetcuti, A, Margan, S, Russell, P, Mann, S, Millar, D, Clark, S, Rogers, J, Handelsman, D, Dong, Q. Loss of annexin II heavy and light chains in prostate cancer and its precursors. Cancer research. 2001; 61:6331-4

Foxley, G, Dong, Q, Handelsman, D. Quantitative reverse transcriptase polymerase chain reaction assay for mouse androgen receptor mRNA. Endocrine. 2001; 15:193-8

Chetcuti, A, Margan, S, Mann, S, Russell, P, Handelsman, D, Rogers, J, Dong, Q. Identification of differentially expressed genes in organ-confined prostate cancer by gene expression array. The Prostate. 2001; 47:132-40

2000

Chua, E, Wu, W, Tran, K, McCarthy, S, Lauer, C, Dubourdieu, D, Packham, N, O'Brien, C, Turtle, J, Dong, Q. Prevalence and distribution of ret/ptc 1, 2, and 3 in papillary thyroid carcinoma in New Caledonia and Australia. The Journal of Clinical Endocrinology & Metabolism. 2000; 85:2733-2739

Chua, E, Young, L, Wu, W, Turtle, J, Dong, Q. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. Genomics. 2000; 69:342-347

Margan, S, Handelsman, D, Mann, S, Russell, P, Rogers, J, Khadra, M, Dong, Q. Quality of nucleic acids extracted from fresh prostatic tissue obtained from TURP procedures. Journal of Urology. 2000; 163:613-615