Professor Rebecca S Mason
F13 - Anderson Stuart Building
The University of Sydney NSW 2006 Australia |
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Professor Mason's research program has developed over many years in the fields of bone and skin. The link between them is vitamin D, which is made in skin and is important in bone, but, as this research has discovered, important in skin for photoprotection as well. The link between bone and skin is Vitamin D. In particular, her group’s studies in skin have shown that the active vitamin D hormone is synthesised locally by melanoma cells and causes their differentiation. The group also showed for the first time that Vitamin D compounds formed in skin by the action of UV light contribute to endogenous photoprotection, including a reduction in DNA damage and UV-induced immunosuppression, through a reduction in nitric oxide products and an increase in p53 expression. Professor Mason has served on the Editorial Board of the Journal of Bone and Mineral Research and on National Health and Medical Research Council Grant Review Panels for Endocrinology and Reproduction and Musculoskeletal diseases. She is a member of the Technical Committee of the Commission Internationale de L’Eclairage (International Commission of Illumination) on Sunlight, Health and Vitamin D. She serves on a committee updating Clinical Guidelines for melanoma prevention and management for the National Health and Medical Research Council.
bone and mineral metabolism; osteoporosis; sun-protection
bone and mineral metabolism; osteoporosis; sun-protection
Current national competitive grants
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2009 |
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Drug-delivery coating for a new generation of orthopaedic implants |
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| ARC Discovery Project | $325,000 over 3 years |
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2008 |
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Mechanisms of photoprotection by vitamin D and analogs |
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| NHMRC Project Grant | $420,563 over 3 years |
2010
- Brock, K, Huang, W, Fraser, D, Ke, L, Tseng, M, Stolzenberg-Solomon, R, U Peters, Z, Ahn, J, Purdue, M, Mason, R, McCarty, C, Ziegler, R, Graubard, B. LOW VITAMIN D STATUS IS ASSOCIATED WITH PHYSICAL INACTIVITY, OBESITY AND LOW VITAMIN D INTAKE IN A LARGE US SAMPLE OF HEALTHY MIDDLE-AGED MEN AND WOMEN. The Journal of steroid biochemistry and molecular biology. 2010; :
- Mason, R, Sequeira, V, Dixon, K, Gordon-Thomson, C, Pobre, K, Dilley, A, Mizwicki, M, Norman, A, Feldman, D, Halliday, G, Reeve, V. PHOTOPROTECTION BY 1alpha,25-DIHYDROXYVITAMIN D AND ANALOGS: FURTHER STUDIES ON MECHANISMS AND IMPLICATIONS FOR UV-DAMAGE. The Journal of steroid biochemistry and molecular biology. 2010; :
- Dixon, K, Sequeira, V, Camp, A, Mason, R. Vitamin D-fence. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2010; 9:564-70
2009
- Brennan, T, Rybchyn, M, Green, W, Atwa, S, Conigrave, A, Mason, R. Osteoblasts play key roles in the mechanisms of action of strontium ranelate. British journal of pharmacology. 2009; 157:1291-300
- Huang, H, Brennan, T, Muir, M, Mason, R. Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. Journal of cellular physiology. 2009; 220:267-275
- Dixon, K, Mason, R. Vitamin D. The international journal of biochemistry & cell biology. 2009; 41:982-5
- McCombie, A, Mason, R, Damian, D. Vitamin D deficiency in Sydney skin cancer patients. The Medical Journal of Australia. 2009. p. 102.
- Sequeira, V, Dixon, K, Mason, R. Resisting the sun with Vitamin D. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2009; 9:126-136
- Diamond, T, Mason, R. Understanding the importance of vitamin D for bone and systemic health. Medicine Today. 2009; 10:1
2008
- Javeri, A, Huang, X, Bernerd, F, Mason, R, Halliday, G. Human 8-oxoguanine-DNA glycosylase 1 protein and gene are expressed more abundantly in the superficial than basal layer of human epidermis. DNA repair. 2008; 7:1542-50
- Rohanizadeh, R, Swain, M, Mason, R. Gelatin sponges (Gelfoam( (R) )) as a scaffold for osteoblasts. Journal of materials science. Materials in medicine. 2008; 19:1173-82
- Sanchez Riera, L, Wilson, N, Sambrook, P, Kok, C, Cumming, R, Cameron, I, Chen, J, Simpson, J, Mason, R, Seibel, M, March, L. Trends in calcium and vitamin D usage among older people in nursing care facilities in Australia: still falling short of the guidelines. International Journal of Rheumatic Diseases. 2008; 11:430-434
2007
- Gorman, S, Kuritzky, L, Judge, M, Dixon, K, McGlade, J, Mason, R, Finlay-Jones, J, Hart, P. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. Journal of immunology. 2007; 179:6273-6283
- Lee, H, Mun, H, Lewis, N, Crouch, M, Culverston, E, Mason, R, Conigrave, A. Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation. The Biochemical journal. 2007; 404:141-149
- Ismail, F, Rohanizadeh, R, Atwa, S, Mason, R, Ruys, A, Martin, P, Bendavid, A. The influence of surface chemistry and topography on the contact guidance of MG63 osteoblast cells. Journal of materials science. Materials in medicine. 2007; 18:705-14
- Gupta, R, Dixon, K, Deo, S, Holliday, C, Slater, M, Halliday, G, Reeve, V, Mason, R. Photoprotection by 1,25 Dihydroxyvitamin D(3) Is Associated with an Increase in p53 and a Decrease in Nitric Oxide Products. The Journal of investigative dermatology. 2007; 127:707-15
- Ma, W, Ruys, A, Mason, R, Martin, P, Bendavid, A, Liu, Z, Ionescu, M, Zreiqat, H. DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials. 2007; 28:1620-8
- Brock, K, Cant, R, Clemson, L, Mason, R, Fraser, D. Effects of diet and exercise on plasma vitamin D (25(OH)D) levels in Vietnamese immigrant elderly in Sydney, Australia. The Journal of steroid biochemistry and molecular biology. 2007; 103:786-792
- Dixon, K, Deo, S, Norman, A, Bishop, J, Halliday, G, Reeve, V, Mason, R. In vivo relevance for photoprotection by the vitamin D rapid response pathway. The Journal of steroid biochemistry and molecular biology. 2007; 103:451-456
- Brennan, T, Rybchyn, M, Halbout, P, Conigrave, A, Mason, R. Strontium ranelate effects in human osteoblasts support its uncoupling effect on bone formation and bone resorption. CALCIFIED TISSUE INTERNATIONAL. 2007; 80:S72-S73
- Brennan, T, Rybchyn, M, Conigrave, A, Mason, R. Strontium ranelate effects on bone formation and bone resorption: an in vitro in human osteoblasts. OSTEOPOROSIS INTERNATIONAL. 2007; 18:S166-S167
2006
- Stewart, I, Roddie, C, Gill, A, Clarkson, A, Mirams, M, Coyle, L, Ward, C, Clifton-Bligh, P, Robinson, B, Mason, R, Clifton-Bligh, R. Elevated serum FGF23 concentrations in plasma cell dyscrasias. Bone. 2006; 39:369-76
- Everitt, A, Hilmer, S, Brand-Miller, J, Jamieson, H, Truswell, A, Sharma, A, Mason, R, Morris, B, Le Couteur, D. Dietary approaches that delay age-related diseases. Clinical Interventions in Aging. 2006; 1:11-31
2005
- Dixon, K, Deo, S, Wong, G, Slater, M, Norman, A, Bishop, J, Posner, G, Ishizuka, S, Halliday, G, Reeve, V, Mason, R. Skin cancer prevention: a possible role of 1,25dihydroxyvitamin D3 and its analogs. The Journal of steroid biochemistry and molecular biology. 2005; 97:137-43
- Stewart, I, Roddie, C, Gill, A, Clarkson, A, Mirams, M, Nelson, A, Coyle, L, Ward, C, Clifton-Bligh, P, Robinson, B, Mason, R, Clifton-Bligh, R. Elevated serum FGF23 concentrations in plasma cell dyscrasias. Journal of Bone and Mineral Research. 2005; 20:S116-S116
- Diamond, T, Eisman, J, Mason, R, Nowson, C, Pasco, J, Sambrook, P, Wark, J. Vitamin D and adult bone health in Australia and New Zealand: a position statement. Medical Journal of Australia. 2005; 182:281-285
- Sivagurunathan, S, Muir, M, Brennan, T, Seale, J, Mason, R. Influence of glucocorticoids on human osteoclast generation and activity. Journal of bone and mineral research. 2005; 20:390-8
- Gordon-Thomson, C, Jones, J, Mason, R, Moore, G. ErbB receptors mediate both migratory and proliferative activities in human melanocytes and melanoma cells. Melanoma research. 2005; 15:21-8
- Eisman, J, Ebeling, P, Flicker, L, Hearnden, N, Mason, R, Pasco, J, Reid, I, Sambrook, P, Stenmark, J, Wark, J. Recommendations from the vitamin D and calcium forum. Medicine Today. 2005; 6:43-50
2004
- Mirams, M, Robinson, B, Mason, R, Nelson, A. Bone as a source of FGF23: regulation by phosphate?. Bone. 2004; 35:1192-9
- Wong, G, Gupta, R, Dixon, K, Deo, S, Choong, S, Halliday, G, Bishop, J, Ishizuka, S, Norman, A, Posner, G, Mason, R. 1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway. The Journal of steroid biochemistry and molecular biology. 2004; 89-90:567-70
- Nowson, C, Diamond, T, Pasco, J, Mason, R, Sambrook, P, Eisman, J. Vitamin D in Australia. Issues and recommendations. Australian family physician. 2004; 33:133-8
2003
- Sambrook, P, Hughes, D, Nelson, A, Robinson, B, Mason, R. Osteocyte viability with glucocorticoid treatment: relation to histomorphometry. Annals of the rheumatic diseases. 2003; 62:1215-1217
- Nelson, A, Bligh, R, Mirams, M, Gill, A, Au, A, Clarkson, A, Jüppner, H, Ruff, S, Stalley, P, Scolyer, R, Robinson, B, Mason, R, Bligh, P. Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia. The Journal of clinical endocrinology and metabolism. 2003; 88:4088-4094
2002
- Nelson, A, Barden, J, Martin, E, Tasevski, V, Hogan, J, Mason, R, Robinson, B. Bioactivity of PTH/PTHrP analogs lacking the 1-14 N-terminal domain. Molecular and cellular endocrinology. 2002; 189:37-49
- Mason, R, Holliday, C, Gupta, R. 1,25 Dihydroxyvitamin D and photoprotection in skin cells. In: Modern Trends in Skin Pharmacology. Athens: Parissianos Medical Publications 2002. p. 59-66.
- Sutton, R, Gordon-Thompson, C, Mason, R, Moore, I. Tyr-TGF alpha transgenic mice develop ocular melanocytic lesions. Melanoma Research. 2002; 12:1-5
2001
- Nelson, A, Mason, R, Robinson, B, Hogan, J, Martin, E, Ahlström, H, Aström, G, Larsson, T, Jonsson, K, Wibell, L, Ljunggren, O. Diagnosis of a patient with oncogenic osteomalacia using a phosphate uptake bioassay of serum and magnetic resonance imaging. European journal of endocrinology / European Federation of Endocrine Societies. 2001; 145:469-76
- Sambrook, P, Raj, A, Hunter, D, Naganathan, V, Mason, R, Robinson, B. Osteoporosis with low dose corticosteroids: contribution of underlying disease effects and discriminatory ability of ultrasound versus bone densitometry. The Journal of rheumatology. 2001; 28:1063-7
- Holm, I, Nelson, A, Robinson, B, Mason, R, Marsh, D, Cowell, C, Carpenter, T. Mutational analysis and genotype-phenotype correlation of the PHEX gene in X-linked hypophosphatemic rickets. Journal of Clinical Endocrinology and Metabolism. 2001; 20:177-192
- Holm, I, Nelson, A, Robinson, B, Mason, R, Marsh, D, Cowell, C, Carpenter, T. Mutational analysis and genotype-phenotype correlation of the PHEX gene in X-Linked hypophosphphatiemic rickets. Endocrinology. 2001; 17(6):567-577
- Numkung-Matthai, H, Appleyard, R, Jansen, J, Lin, J, Maastricht, S, Swain, M, Mason, R, Murrell, A, Diwan, A, Diamond, T. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone. 2001; 47:230-259
- Nelson, A, Holm, I, Robinson, B, Mason, R, Hogan, J. Phosphate wasting in oncogenic osteomalacia: PHEX Is normal and the tumor-derived factor has unique properties. Bone. 2001; 64:1247-1254
- Nelson, A, Hogan, J, Holm, I, Robinson, B, Mason, R. Phosphate wasting in oncogenic osteomalacia: PHEX is normal and the tumor-derived factor has unique properties. Bone. 2001; 66:677-680
- Gordon-Thomson, C, Mason, R, Moore, G. Regulation of epidermal growth factor receptor expression in human melanocytes. Experimental Dermatology. 2001; 25:84-89
- Mason, R, Diamond, T. Vitamin D deficiency and multicultural Australia. Medical Journal of Australia. 2001; 45:350-353
2000
- Seeto, C, Jayram, S, Foe, K, Brown, K, Hughes, J, Mason, R, Armour, C, Seale, J, Namkung-Matthai, H. Differential potency of beclomethasone esters in-vitro on human t-lymphocyte cytokine production and osteoblast activity. Journal of Pharmacy and Pharmacology. 2000; 52:417-423
- Mason, R, Holliday, C. 1,25 dihydroxyvitamin d contributes to photoprotection in skin cells. Vitamin D Endocrine System: structural, biological, genetic and clinical aspects. 2000; Nashville Tennessee, USA; 2000
- Seeto, C, Heeja, N, Jayram, S, Foe, K, Brown, K, Hughes, J, Mason, R, Armour, C, Seale, J. Differential potency of beclomethasone esters in-vitro on human T-lymphocyte cytokine production and osteoblast activity. Journal of Pharmacy and Pharmacology. 2000; 52:417-423
- Mason, R. Effect of Vitamin D on Melanocytes and Its Role in Melanogenesis. In: Vitamin D in Dermatology. : Marcel Decker Inc 2000. p. 123-132.
- Diwan, A, Zhu, W, Murrell, G, Kumar, S, Diamond, T, Mason, R, Namkung-Matthai, H. Nitric oxide regulation of alkaline phosphatase activity in fracture healing - a study in rat fracture callus explant culture system. Redox Report. 2000; 5 (2-3):126-127




