Cancer Therapeutics Research Group
Research in this laboratory is also related to Infection, immunity & inflammation.
Head of laboratory:
The main aim of this laboratory is to investigate the interactions between malignant cells and immune cells that regulate tumour progression. Tumour-associated macrophages are one of the main immune cells in cancer that support tumour growth and metastasis in most human cancers. Malignant cells secrete cytokines and chemokines that alter the phenotype and behaviour of tumour-associated macrophages to promote tumour growth and orchestrate the immunosuppressant behaviour of the adaptive immune responses. Inhibiting the communication between cancer cells and tumour-associated macrophages is becoming an exciting potential target for cancer intervention strategies. This laboratory conducts translational and clinical studies aimed to identify new molecular targets in cancer and in collaboration with biological chemists at the University of Sydney design and evaluate new cancer therapeutic agents.
