The University of Sydney
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Dr Rachel Codd

T: +61 2 9351 6738
F: +61 2 9351 3868
D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

Research interests

A chemical biology approach to drug design and development; chemical proteomics of bacterial iron uptake; EPR spectroscopy.

Current national competitive grants

2009

Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload
NHMRC Project Grants $264,250 over 3 years

Publications

2010

Liu, J, Obando, D, Schipanski, L, Groebler, L, Witting, P, Kalinowski, D, Richardson, D, Codd, R. Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of medicinal chemistry. 2010; 53:1370-82

2009

Codd, R, Braich, N, Liu, J, Soe, C, Pakchung, A. Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. The international journal of biochemistry & cell biology. 2009; 41:736-9
Levina, A, Codd, R, Lay, P. Chromium in Cancer and Dietary Supplements. In: High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine. United States: Springer 2009. p. 551-579.
Liu, J, Clegg, J, Codd, R. 2,5-Dioxopyrrolidin-1-yl adamantane-1-carboxylate. Acta Crystallographica. Section E: Structure Reports Online. 2009; E65:o1742-o1743
Liu, J, Clegg, J, Codd, R. Methyl 3-[(1-adamantatanylcarbonyloxy)aminocarbonyl]propanoate. Acta Crystallographica. Section E: Structure Reports Online. 2009; E65:o1742-o1743

2008

Pakchung, A, Soe, C, Codd, R. Studies of Iron-Uptake Mechanisms in Two Bacterial Species of the Shewanella Genus Adapted to Middle-Range (Shewanella putrefaciens) or Antarctic (Shewanella gelidimarina) Temperatures. Chemistry & biodiversity. 2008; 5:2113-23
Braich, N, Codd, R. Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(iii)-binding metabolites directly from bacterial culture supernatants. The Analyst. 2008; 133:877-880
Codd, R. Traversing the coordination chemistry and chemical biology of hydroxamic acids. Coordination Chemistry Reviews. 2008; 252:1387-1408

2006

Codd, R, Lay, P, Tsibakhashvili, N, Kalabegishvili, T, Murusidze, I, Holman, H. Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of inorganic biochemistry. 2006; 100:1827-33
Pakchung, A, Simpson, P, Codd, R. Life on Earth. Extremophiles Continue to Move the Goal Posts. Environmental Chemistry. 2006; 3:77-93
Fainerman-Melnikova, M, Clegg, J, Codd, R. Aqua[bis(2-pyridylmethyl)amine][chelidonato(1.5-)]copper(II) chelidonate(0.5-) monohydrate. Acta Crystallographica. Section E: Structure Reports Online. 2006; 62:m3582-m3584

2005

Gez, S, Luxenhofer, R, Levina, A, Codd, R, Lay, P. Chromium(V) complexes of hydroxamic acids: formation, structures, and reactivities. Inorganic Chemistry. 2005; 44:2934-2943
Fainerman-Melnikova, M, Szabó-Plánka, T, Rockenbauer, A, Codd, R. Coordination modes between copper(II) and N-acetylneuraminic (sialic) acid from a 2D-simulation analysis of EPR spectra. Implications for copper mediation of sialoglycoconjugate chemistry relevant to human biology. Inorganic Chemistry. 2005; 44:2531-2543

2004

Codd, R. Metalloglycomics: a new perspective upon competitive metal-carbohydrate binding using EPR spectroscopy. Chemical Communications. 2004; 0:2653-2655
Levina, A, Codd, R, Foran, G, Hambley, T, Maschmeyer, T, Masters, A, Lay, P. X-ray absorption spectroscopic studies of chromium(V/IV/III)- 2-ethyl-2-hydroxybutanoato(2-/1-) complexes. Inorganic chemistry. 2004; 43:1046-1055

2003

Codd, R, Lay, P. Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI) compounds. Chemical research in toxicology. 2003; 16:881-892
Codd, R, Irwin, J, Lay, P. Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion in Chemical Biology. 2003; 7:213-219
Codd, R. Biomolcules from Extremophilic Life. In: From Zero to Infinity. Australia: University of Sydney 2003. p. 37-48.
Levina, A, Codd, R, Dillon, C, Lay, P. Chromium in biology: Toxicology and nutritional aspects. Progress in Inorganic Chemistry. 2003; 51:145-250

2002

Codd, R, Astashkin, A, Pacheco, A, Raitsimring, A, Enemark, J. Pulsed ELDOR spectroscopy of the Mo(V)/Fe(III) state of sulfite oxidase prepared by one-electron reduction with Ti(III) citrate. Journal of Biological Inorganic Chemistry. 2002; 7:338-350

2001

Codd, R, Lay, P. Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society. 2001; 123:11799-11800
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