Professor Brian Morris

T:  +61 2 9351 3688 F:  +61 2 9351 2227 F13 - Anderson Stuart Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Marques, F, Campain, A, Yang, Y, Morris, B. Meta-Analysis of Genome-Wide Gene Expression Differences in Onset and Maintenance Phases of Genetic Hypertension. Hypertension. 2010; :

Gray, R, Bailey, R, Morris, B. Keratinization of the adult male foreskin and implications for male circumcision. AIDS (London, England). 2010; 24:1381

Morris, B. Sympathetic meta-analysis of adrenoceptor gene variants in hypertension. American Journal of Hypertension. 2010; 23:225

Marques, F, Markus, M, Morris, B. The molecular basis of longevity, and clinical implications. Maturitas. 2010; 65:87-91

2009

Marques, F, Markus, M, Morris, B. Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits. The international journal of biochemistry & cell biology. 2009; 41:2125-8

Morris, B, Bailis, S, Waskett, J, Wiswell, T, Halperin, D. Medicaid coverage of newborn circumcision: a health parity right of the poor. American journal of public health. 2009. p. 969-971.

Morris, B. Might a leptin gene variant affect blood pressure in obese brazilians?. American journal of hypertension. 2009; 22:467

Loughlin, F, Mansfield, R, Vaz, P, McGrath, A, Setiyaputra, S, Gamsjaeger, R, Chen, E, Morris, B, Guss, J, Mackay, J. The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106:5581-5586

Markus, M, Morris, B. RBM4: A multifunctional RNA-binding protein. The international journal of biochemistry & cell biology. 2009; 41:740-3

Pönighaus, C, Speirs, H, Morris, B, Kuhn, J, Kleesiek, K, Götting, C. Xylosyltransferase gene variants and their role in essential hypertension. American journal of hypertension. 2009; 22:432-436

Waskett, J, Morris, B, Weiss, H. Errors in meta-analysis by Van Howe. International journal of STD & AIDS. 2009. p. 216-218; author reply 218-20.

Morris, B. GRK4 genetics and response to beta-blocker. American journal of hypertension. 2009; 22:235-236

Marques, F, Markus, M, Morris, B. Hormesis as a pro-healthy aging intervention in human beings?. Dose-response : a publication of International Hormesis Society. 2009; 8:28-33

2008

Morris, B. Fluorescence activated cell sorting of transiently transfected As4.1 cells shows renin enhancer directs on/off switching of renin promoter in vitro. Clinical and experimental pharmacology & physiology. 2008; 35:367-371

Martin, S, Markus, M, Morris, B, Davisson, R, Lawrence, A, van den Buuse, M. Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice?. Neuropharmacology. 2008; 54:399-404

Waskett, J, Morris, B. Re: 'RS Van Howe, FM Hodges. The carcinogenicity of smegma: debunking a myth.' An example of myth and mythchief making?. Journal of the European Academy of Dermatology and Venereology : JEADV. 2008; 22:131

Mangs, A, Morris, B. ZRANB2: Structural and functional insights into a novel splicing protein. The international journal of biochemistry & cell biology. 2008; 40:2353-7

Markus, M, Morris, B. Resveratrol in prevention and treatment of common clinical conditions of aging. Clinical Interventions in Aging. 2008; 3:331-339

Abete, P, Calabrese, E, Ji, L, Kristensen, T, Le Bourg, E, Loeschcke, V, Morris, B, Rengo,, F, Rattan, S, Safwat, A, Sarup, P, Sørensen, J, Vaiserman, A. Mild Stress and Healthy Aging: Perspectives for Human Beings. In: Mild Stress and Healthy Aging. Netherlands: Springer Science+Business Media 2008. p. 171-183.

Morris, B. How Xenohormetic Compounds Confer Health Benefits. In: Mild Stress and Healthy Aging. Netherlands: Springer Science+Business Media 2008. p. 115-138.

Morris, B, Halperin, D, Klausner, J. Cut!. New Scientist. 2008; 2670:20-21

Halperin, D, Wamai, R, Weiss, H, Hankins, C, Agot, K, Abdool Karim, Q, Shisana, O, Bailey, R, Betukumesu, B, Bongaarts, J, Bowa, K, Cash, R, al, E, Morris, B. Male circumcision is an efficacious, lasting and cost-effective strategy for combating HIV in high-prevalence AIDS epidemics. Future HIV Therapy. 2008. p. 399-405.

2007

Markus, M, Goy, C, Adams, D, Lovicu, F, Morris, B. Renin Enhancer Is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension. 2007; 50:933-8

Morris, B. Why circumcision is a biomedical imperative for the 21(st) century. BioEssays : news and reviews in molecular, cellular and developmental biology. 2007; 29:1147-58

Stefani, M, Markus, M, Lin, R, Pinese, M, Dawes, I, Morris, B. The Effect of Resveratrol on a Cell Model of Human Aging. Annals of the New York Academy of Sciences. 2007; 1114:407-18

Jackson, K, Head, G, Morris, B, Chin-Dusting, J, Jones, E, La Greca, L, Mayorov, D. Reduced cardiovascular reactivity to stress but not feeding in renin enhancer knockout mice. American journal of hypertension : journal of the American Society of Hypertension. 2007; 20:893-899

Morris, B, Waskett, J, Bailis, S. Case number and the financial impact of circumcision in reducing prostate cancer. BJU international. 2007; 100:5-6

Waskett, J, Morris, B. Fine-touch pressure thresholds in the adult penis. BJU international. 2007. p. 1551-1552.

Yang, Z, Venardos, K, Jones, E, Morris, B, Chin-Dusting, J, Kaye, D. Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. Circulation. 2007; 115:1269-1274

Morris, B. Climate not cultivars in the NO-ing of red wines. Journal of hypertension. 2007; 25:501-503

Morris, B, Rose, B. Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens. Clinical chemistry and laboratory medicine : CCLM / FESCC. 2007; 45:577-591

Mangs, A, Morris, B. The human pseudoautosomal region: origin, function and future. Current Genomics. 2007; 8:129-136

Morris, B. Circumcision in Australia: prevalence and effects on sexual health. International journal of STD & AIDS. 2007. p. 69-70.

2006

Morris, B, Castellsague, X, Bailis, S. Re: Cost analysis of neonatal circumcision in a large health maintenance organization - E. J. Schoen, C. J. Colby and T. T. To - J Urol, 175 : 1111-1115, 2006. Journal of Urology. 2006; 176:2315-2316

Adams, D, Head, G, Markus, M, Lovicu, F, van der Weyden, L, Köntgen, F, Arends, M, Thiru, S, Mayorov, D, Morris, B. Renin enhancer is critical for control of renin gene expression and cardiovascular function. The Journal of biological chemistry. 2006; 281:31753-61

Markus, M, Heinrich, B, Raitskin, O, Adams, D, Mangs, H, Goy, C, Ladomery, M, Sperling, R, Stamm, S, Morris, B. WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Experimental cell research. 2006; 312:3379-88

Markus, M, Morris, B. Lark Is the Splicing Factor RBM4 and Exhibits Unique Subnuclear Localization Properties. DNA and cell biology. 2006; 25:457-464

Yang, Z, Morris, B, Kaye, D. Investigation of genetic and biochemical determinants of depressed L-arginine transport in human hypertension. Journal of the American College of Cardiology. 2006; 47:324A-325A

Morris, B, Bailis, S, Castellsague, X, Wiswell, T, Halperin, D. RACP's policy statement on infant male circumcision is ill-conceived. Australian and New Zealand journal of public health. 2006; 30:16-22; discussion 22-5

Mangs, A, Speirs, H, Goy, C, Adams, D, Markus, M, Morris, B. XE7: A novel splicing factor that interacts with ASF/SF2 and ZNF265. Nucleic acids research. 2006; 34:4976-86

Everitt, A, Hilmer, S, Brand-Miller, J, Jamieson, H, Truswell, A, Sharma, A, Mason, R, Morris, B, Le Couteur, D. Dietary approaches that delay age-related diseases. Clinical Interventions in Aging. 2006; 1:11-31

2005

Speirs, H, Wang, W, Benjafield, A, Morris, B. No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36. Journal of hypertension. 2005; 23:1491-6

Speirs, H, Benjafield, A, Wang, W, Morris, B. Association analyses of tumor necrosis factor receptor 2 gene (TNFRSF1B) polymorphisms in essential hypertension. Clinical and Experimental Pharmacology and Physiology. 2005; 32:A27-A27

Speirs, H, Morris, B. No association of podocin (NPHS2) polymorphism with essential hypertension. Clinical and Experimental Pharmacology and Physiology. 2005; 32:A26-A27

Morris, B. A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. Journal of hypertension. 2005; 23:1285-309

Benjafield, A, Wang, W, Speirs, H, Morris, B. Genome-wide scan for hypertension in Sydney Sibships: the GENIHUSS study. American journal of hypertension. 2005; 18:828-32

Adams, D, van der Weyden, L, Gergely, F, Arends, M, Ng, B, Tannahill, D, Kanaar, R, Markus, A, Morris, B, Bradley, A. BRCTx is a novel, highly conserved RAD18-interacting protein. Molecular and cellular biology. 2005; 25:779-88

Morris, B. Cervical human papillomavirus screening by PCR: advantages of targeting the E6/E7 region. Clinical chemistry and laboratory medicine : CCLM / FESCC. 2005; 43:1171-7

2004

Morris, B, Adams, D, Beveridge, D, van der Weyden, L, Mangs, H, Leedman, P. cAMP controls human renin mRNA stability via specific RNA-binding proteins. Acta physiologica Scandinavica. 2004; 181:369-73

Benjafield, A, Wang, W, Morris, B. No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. American journal of hypertension : journal of the American Society of Hypertension. 2004; 17:624-8

Blessing, E, Solomon, S, Hashemi-Nezhad, M, Morris, B, Martin, P. Chromatic and spatial properties of parvocellular cells in the lateral geniculate nucleus of the marmoset (Callithrix jacchus). The Journal of physiology. 2004; 557:229-45

Speirs, H, Katyk, K, Kumar, N, Benjafield, A, Wang, W, Morris, B. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. Journal of hypertension. 2004; 22:931-6

Morris, B, Bailis, S. Circumcision rate too low?. ANZ journal of surgery. 2004. p. 386-7; author reply 388.

Speirs, H, Morris, B. WNK4 intron 10 polymorphism is not associated with hypertension. Hypertension. 2004; 43:766-8

2003

Adams, D, Beveridge, D, van der Weyden, L, Mangs, H, Leedman, P, Morris, B. HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. The Journal of biological chemistry. 2003; 278:44894-44903

Plambeck, C, Kwan, A, Adams, D, Westman, B, van der Weyden, L, Medcalf, R, Morris, B, Mackay, J. The structure of the zinc finger domain from human splicing factor ZNF265 fold. The Journal of biological chemistry. 2003; 278:22805-11

Lin, R, Wang, X, Dalziel, B, Caterson, I, Morris, B. Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obesity research. 2003; 11:802-8

Lin, R, Wang, X, Morris, B. Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension. 2003; 41:404-407

Morris, B. Drugs capable of increasing lifespan. Guild Bulletin. 2003; Mar-03:28-28

Morris, B, Lin, R, Wang, X. Response. Hypertension. 2003; :

Kumar, N, Benjafield, A, Lin, R, Wang, W, Stowasser, M, Morris, B. Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension. Journal Of Hypertension. 2003; 21:1331-1337

Morris, B, Benjafield, A, Lin, R. Essential hypertension: genes and dreams. Clinical Chemistry And Laboratory Medicine. 2003; 41 (7):834-844

Morris, B. Renin: from 'pro' to promoter. Bioessays. 2003; 25:520-527

Morris, B, Lin, R, Wang, X, Dalziel, B, Caterson, I. Response: Central obesity is associated with glucocorticoid receptor N363S variant: Big picture sheds light. Obesity Research. 2003; 11 (12):1607-1609

Zhang, Y, Schyvens, C, Mckenzie, K, Morris, B, Whitworth, J. Lipopolysaccharide reverses adrenocorticotrophic hormone-induced hypertension in the rat. Hypertension Research. 2003; 26:427-432

Plambeck, C, Kwan, A, Westman, B, Van Der Weyden, L, Adams, D, Medcalf, R, Morris, B, Mackay, J. The structure of the Zinc finger domain fro human splicing factor ZNF265 fold. Journal Of Biological Chemistry. 2003; 278 (25):22805-22811

Benjafield, A, Iwai, N, Ishikawa, K, Wang, W, Morris, B. Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension. Hypertension Research. 2003; 26 (8):591-595

Lin, R, Schyvens, C, Zhang, Y, Whitworth, J, Morris, B. Tumor necrosis factor receptor 2 mRNA in rat models of hypertension. American Journal Of Hypertension. 2003; 16:685-688

Benjafield, A, Katyk, K, Morris, B. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. Clinical Genetics. 2003; 64:433-438

Morris, B. To the Editor. Medical Journal Of Australia. 2003; 178:588-589

2002

Morris, B. Critique of chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension by Rutherford et al., human genetics, published online september 2001. Human Genetics. 2002; 110:98-99

Lin, R, Morris, B. Association analysis of polymorphisms at the interleukin-1 locus in essential hypertension. American Journal Of Medical Genetics. 2002; 107:311-316

Morris, B, Markus, M, Colagiuri, S, Wang, X, Adams, D, Glenn, C. Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. Journal Of Molecular Medicine-Jmm. 2002; 80:96-104

2001

Adams, D, van der Weyden, L, Mayeda, A, Stamm, S, Morris, B, Rasko, J. ZNF265--a novel spliceosomal protein able to induce alternative splicing. The Journal of cell biology. 2001; 154:25-32

Lou, Y, Wen, C, Li, M, Adams, D, Wang, M, Yang, F, Morris, B, Whitworth, J. Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension. Hypertension. 2001; 37:1164-70

Benjafield, A, Wang, X, Colagiuri, S, Morris, B, Jeyasingam, C, Jeyasingam, C. TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes. Diabetes Care. 2001; 22:263-270

Benjafield, A, Lin, R, Dalziel, B, Gosby, A, Caterson, I, Morris, B. G-protein beta3 subunit gene splice variant in obesity and overweight. International Journal of Obesity. 2001; 433:91-99

Morris, B, Wilcken, D, Wang, X, Jeyasingam, C, Jeyasingam, C. Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease. Clinical Science. 2001; 10:317-328

Benjafield, A, Wang, X, Morris, B. Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease. Journal of Molecular Medicine-Jmm. 2001; 41:145-152

Lin, R, Benjafield, A, Morris, B, Ericsson, J. Association of beta 2-adrenoceptor Gln27Glu variant with body weight but not hypertension. American Journal of Hypertension. 2001; 133:337-344

Morris, B, Adams, D, Van Der Weyden, L. Renin Gene expression: the switch and the fingers. Clinical and Experimental Pharmacology and Physiology. 2001; 29:104-107

2000

Lin, R, Morris, B. Polymorphism (1339G>A;A447T) in exon 13 of human kidney chloride channel gene CLCNKA. Human Mutation: Mutation and Polymorphism Report. 2000; 139:online-online

Morris, B, Benjafield, A, Ishikawa, K, Iwai, N. Polymorphism (-173G>A) in promoter of human epithelial sodium channel gamma subunit gene (SCNNIG) and association analysis in essential hypertension. Human Mutation: Mutation and Polymorphism Report. 2000; 213:online-online

Morris, B, Benjafield, A. Association Analyses of Endothelial Nitric Oxide Synthase Gene Polymorphisms in Essential Hypertension. Amercian Journal of Hypertension. 2000; 13:994-998

Adams, D, Morris, B, Van Der Weyden, L. Capacity for purinergic control of renin promoter via P2Y11 receptor and cAMP pathways. Hypertension. 2000; 36:1093-1098

Adams, D, Lovicu, F, Morris, B, Kovacic, A, Copeland, N, Gilbert, D, Jenkins, N, Ioannou, P, Van Der Weyden, L. Chromosome localisation and characterisation of the mouse and human zinc finger protein 265 gene. Cytogenetics and Cell Genetics. 2000; 88:68-73

Benjafield, A, Morris, B, Jeyasingam, C. Linkage and association of tumour necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor. Human Molecular Genetics. 2000; 9:1943-1949