The University of Sydney
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Dr Stuart Cordwell

T: +61 2 9351 6050
F: +61 2 9351 4726
G08 - Biochemistry Building
The University of Sydney
NSW 2006 Australia

Research interests

Our group is primarily interested in utilizing the tools of proteomics to understand disease processes and discover new targets for protein-based diagnosis of disease and potential vaccine and therapeutic targets.

Current national competitive grants

2010

Identification of proteins specific to transmissible Pseudomonas aeruginosa in cystic fibrosis infection
NHMRC Project Grant $427,200 over 3 years

2009

Identification and analysis of novel replication initiation factors in Staphlylococcus aureus
NHMRC Project Grant $299,500 over 3 years
A temporal profile of signalling via phosphorylation during myocardial ischemia / reperfusion injury
NHMRC Project Grants $355,050 over 3 years

Publications

2010

Scott, N, Parker, B, Connolly, A, Paulech, J, Edwards, A, Crossett, B, Falconer, L, Kolarich, D, Djordjevic, S, Hojrup, P, Packer, N, Larsen, M, Cordwell, S. Simultaneous glycan-peptide characterization using hydrophilic interaction chromatography and parallel fragmentation by CID, HCD and ETD-MS applied to the N-linked glycoproteome of Campylobacter jejuni. Molecular & cellular proteomics : MCP. 2010; :
Cordwell, S, Thingholm, T. Technologies for plasma membrane proteomics. Proteomics. 2010; 10:611-27
Scott, N, Marzook, N, Deutscher, A, Falconer, L, Crossett, B, Djordjevic, S, Cordwell, S. Mass spectrometric characterization of the Campylobacter jejuni adherence factor CadF reveals post-translational processing that removes immunogenicity while retaining fibronectin binding. Proteomics. 2010; 10:277-88

2009

Scott, N, Bogema, D, Connolly, A, Falconer, L, Djordjevic, S, Cordwell, S. Mass spectrometric characterization of the surface-associated 42 kDa lipoprotein JlpA as a glycosylated antigen in strains of Campylobacter jejuni. Journal of proteome research. 2009; 8:4654-64
Faulkner, C, Blackman, L, Collings, D, Cordwell, S, Overall, R. Anti-tropomyosin antibodies co-localise with actin microfilaments and label plasmodesmata. European journal of cell biology. 2009; 88:357-69
Scott, N, Cordwell, S. Campylobacter proteomics: guidelines, challenges and future perspectives. Expert review of proteomics. 2009; 6:61-74
Wilton, J, Jenkins, C, Cordwell, S, Falconer, L, Minion, F, Oneal, D, Djordjevic, M, Connolly, A, Barchia, I, Walker, M, Djordjevic, S. Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae. Molecular microbiology. 2009; 71:566-82
Lo, M, Cordwell, S, Bulach, D, Adler, B. Comparative transcriptional and translational analysis of leptospiral outer membrane protein expression in response to temperature. PLoS neglected tropical diseases. 2009; 3:e560

2008

Upritchard, H, Cordwell, S, Lamont, I. Immunoproteomics to examine cystic fibrosis host interactions with extracellular Pseudomonas aeruginosa proteins. Infection and immunity. 2008; 76:4624-32
Edwards, A, White, M, Cordwell, S. The role of proteomics in clinical cardiovascular biomarker discovery. Molecular & cellular proteomics : MCP. 2008; 7:1824-37
Crossett, B, Edwards, A, White, M, Cordwell, S. Statistical Analysis of Image Data Provided by Two-Dimensional Gel Electrophoresis for Discovery Proteomics. In: Methods in Molecular Medicine: Clinical Bioinformatics. New Jersey, USA: Humana Press 2008. p. 271-285.
Cordwell, S, Len, A, Touma, R, Scott, N, Falconer, L, Jones, D, Connolly, A, Crossett, B, Djordjevic, S. Identification of membrane-associated proteins from Campylobacter jejuni strains using complementary proteomics technologies. Proteomics. 2008; 8:122-39
Cordwell, S. Sequential extraction of proteins by chemical reagents. Methods in molecular biology (Clifton, N.J.). 2008; 424:139-46
White, M, Edwards, A, Cordwell, S, Van Eyk, J. Mitochondria: A mirror into cellular dysfunction in heart disease. Proteomics - Clinical Applications. 2008; 2:845-861
Cordwell, S, Crossett, B, White, M. Gel-Based Approaches. In: Proteomics. Germany: Wiley - VCH Verlag GmbH & Co. KGaA 2008. p. 33-57.

2007

Cole, J, Aquilina, J, Hains, P, Henningham, A, Sriprakash, K, Caparon, M, Nizet, V, Kotb, M, Cordwell, S, Djordjevic, S, Walker, M. Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics. 2007; 7:4488-98
Henrich, S, Cordwell, S, Crossett, B, Baker, M, Christopherson, R. The nuclear proteome and DNA-binding fraction of human Raji lymphoma cells. Biochimica et biophysica acta. 2007; 1774:413-432
Clark, D, Dedova, I, Cordwell, S, Matsumoto, I. Altered proteins of the anterior cingulate cortex white matter proteome in schizophrenia. PROTEOMICS CLINICAL APPLICATIONS. 2007; 1:157-166
Harper, C, Cordwell, S, Alexander-Kaufman, K, Matsumoto, I. A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. PROTEOMICS CLINICAL APPLICATIONS. 2007; 1:62-72
Sivagnanasundaram, S, Crossett, B, Dedova, I, Cordwell, S, Matsumoto, I. Abnormal pathways in the genu of the corpus callosum in schizophrenia pathogenesis: a proteome study. PROTEOMICS CLINICAL APPLICATIONS. 2007; 1:1291-1305

2006

White, M, Tchen, A, McCarron, H, Hambly, B, Jeremy, R, Cordwell, S. Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger. Proteomics. 2006; 6:6221-33
Sivagnanasundaram, S, Caixeiro, N, Nesvaderani, M, Dedova, I, Cordwell, S, Matsumoto, I. Proteome profiling of the prefrontal cortex (PFC) and hippocampus of schizophrenia brains. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2006; 141B:698-698
O'brien, E, Dedova, I, Duffy, L, Cordwell, S, Karl, T, Matsumoto, I. Effects of chronic risperidone treatment on the striatal protein profiles in rats. Brain research. 2006; 1113:24-32
White, M, Gundry, R, Cordwell, S. When does a fingerprint constitute a diagnostic?. Lancet. 2006; 368:971-973
Caixeiro, N, Dedova, I, Cordwell, S, Matsumoto, I, Sivagnanasundaram, S. A proteomic analysis of Brodmann's area 46 (BA46) in schizophrenia. Australian and New Zealand Journal of Psychiatry. 2006; 40:A136-A136
Nesvaderani, M, Dedova, I, Cordwell, S, Matsumoto, I, Sivagnanasundaram, S. Identification of proteins differentially expressed in the schizophrenic hippocampus. Australian and New Zealand Journal of Psychiatry. 2006; 40:A137-A137
Sivagnanasundaram, S, Dedova, I, Cordwell, S, Matsumoto, I. Proteome analysis of the corpus callosum of schizophrenia. Australian and New Zealand Journal of Psychiatry. 2006; 40:A124-A124
Cordwell, S. Technologies for bacterial surface proteomics. Current opinion in microbiology. 2006; 9:320-329
White, M, Hambly, B, Jeremy, R, Cordwell, S. Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. Journal of molecular and cellular cardiology. 2006; 40:761-74
Burnett, T, Dinkla, K, Rohde, M, Chhatwal, G, Uphoff, C, Srivastava, M, Cordwell, S, Geary, S, Liao, X, Minion, F, Walker, M, Djordjevic, S. P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae: defined domains of P159 bind heparin and promote adherence to eukaryote cells. Molecular Microbiology. 2006; 60:669-686
Clark, D, Dedova, I, Cordwell, S, Matsumoto, I. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Molecular psychiatry. 2006; 11:459-70, 423
Clark, D, Dedova, I, Cordwell, S, Matsumoto, I. Protein expression profile in the anterior cingulate cortex. Molecular psychiatry. 2006; 11:423

2005

Hambly, B, White, M, Cordwell, S, Tchen, A, McCarron, H, Jeremy, R. Reversible ischemia/reperfusion injury correlates with troponin C modification. Biophysical Journal. 2005; 88:315A-315A

2003

White, M, Cordwell, S, McCarron, H, Tchen, A, Hambly, B, Jeremy, R. Modifications of myosin-regulatory light chain correlate with function of stunned myocardium. Journal of molecular and cellular cardiology. 2003; 35:833-40
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