Centre for Vascular Research University of Sydney
Head of laboratory:
Cellular Imaging Group:
The research program in our laboratory focuses on oxidative processes in vascular medicine
Current research projects aim to:
- Develop novel redox-active drugs that protect against atherosclerotic diseases and diabetes based on their ability to induce the enzyme heme oxygenase-1.
- Enhance present knowledge of heme oxygenase-1 biology at the cellular and whole organism level, with an emphasis on the ability of the enzyme to regulate cell growth, iron homeostasis, and antioxidant activity.
- Investigate the contribution of the enzyme indoleamine 2,3-dioxygense to the regulation of vascular tone, with an emphasis on inflammation and interaction with nitric oxide synthase.
- Identify oxidants and enzymes that affect the redox state and redox processes following receptor tyrosine kinase activation on endothelial cell lines.
Image 1
Atherosclerosis: In situ photographs of the aortic tree of control (A) and probucol-treated (B) apolipoprotein E-deficient mice fed a high fat diet for six months. Atherosclerotic lesions appear white. C and D represent respective cross-sections taken at the aortic sinus and stained with H&E. These lesions are complex and contain cholesterol crystals and macrophage foam cells.
Atherosclerosis: In situ photographs of the aortic tree of control (A) and probucol-treated (B) apolipoprotein E-deficient mice fed a high fat diet for six months. Atherosclerotic lesions appear white. C and D represent respective cross-sections taken at the aortic sinus and stained with H&E. These lesions are complex and contain cholesterol crystals and macrophage foam cells.
Image 2
Expression of IDO in endothelial cells of resistance vessels in mice during systemic inflammation.
Expression of IDO in endothelial cells of resistance vessels in mice during systemic inflammation.
Image 3
Confocal image of multi-colour immunocytochemistry staining. Cos 7 cells expressing Epidermal Growth Factor Receptor GFP fusion protein (green) were stimulated with EGF and stained using a fluorescently labeled anti phosphotyrosine antibody (red). Co-localized green and red proteins are displayed in yellow, where the receptor is phosphorylated.
Confocal image of multi-colour immunocytochemistry staining. Cos 7 cells expressing Epidermal Growth Factor Receptor GFP fusion protein (green) were stimulated with EGF and stained using a fluorescently labeled anti phosphotyrosine antibody (red). Co-localized green and red proteins are displayed in yellow, where the receptor is phosphorylated.
