Publications - details

• 2009
• 2008
• 2007
• 2006
• 2005
• 2004

• Woodward M, Croft K, Mori T, Wang XS, Suarna C, Raftery M, MacMahon S, Stocker R. Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population. Clin Sci 2009;116:53-60
• Wang XS, Mahler, S, Shao B, Heinecke JW, Stocker R. A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL. J Lipid Res 2009;50:586-594
• Patel S, Puranik R, Nakhla S, Lundman P, Stocker R, Wang XS, Rye KA, Barter PJ, Celermajer DS. Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins. Atherosclerosis 2009;204:424-428
• Fu Y, Klonis N, Suarna C, Maghzal G, Stocker R, Tilley L. Phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-Infected erythrocytes. Cytometry A 2009;75:390-404
• Wu BJ, Midwinter R, Cassano C, Beck K, Wang Y, Changsiri B, Gamble JR, Stocker R. Heme oxygenase-1 increases endothelial progenitor cells. Arterioscl Thromb Vasc Biol 2009;in press
• Li C, Stocker R. Heme oxygenase and iron: from bacteria to humans. Redox Report 2009; 14:95-101
• Tan, NY, Li, J-M, Stocker R, Khachigian L Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement. Circ Res 2009;in press
• Maghzal GJ, Leck MC, Cheng Li C, Collinson E, Stocker R. Limited role for the bilirubin-biliverdin redox amplification cycle in cellular antioxidant protection by biliverdin reductase. J Biol Chem 2009;accepted for publication

• Maghzal G, Thomas SR, Hunt NH, Stocker R. Cytochrome b5, not superoxide anion radical, is the major reductant of indoleamine 2,3 dioxygenase in human cells. J Biol Chem 2008;283:12014-12025
• Tanous D, Hime N, Stocker R. Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds. Redox Report 2008;13:48-59

• Glaros EE, Kim WS, Wu BJ, Suarna C, Quinn C, Rye KA, Stocker R, Jessup W, Garner B. Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. Biochem Pharmacol 2007;73:1340-1346
• Wu BJ, Di Girolamo N, Beck K, Hanratty CG, Choy K, Hou JY, Ward MR, Stocker R. Probucol retards compensatory arterial remodeling in apolipoprotein E deficient mice by decreasing macrophage and matrix metalloproteinases-2 and -9. J Pharmacol Exp Ther 2007;321:477-484
• Witting PK, Rayner BS, Wu BJ, Ellis NA, Stocker R. Hydrogen peroxide promotes vascular dysfunction by decreasing nitric oxide bioavailability. Cell Physiol Biochem 2007;20:255-268
• Thomas SR, Terentis AC, Cai H, Takikawa O, Levina A, Lay PA, Freewan M, Stocker R. Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. J Biol Chem 2007;282:23778-23787
• Li C, Hossieny P, Wu BJ, Qawasmeh A, Beck K, Stocker R. Pharmacological induction of heme oxygenase-1. Antiox Redox Signal 2007;9:2227-2240
• Ball HJ, Sanchez-Perez A, Weiser S, Austin CJD, Austelbauer F, Miu J, McQuillan J, Stocker R, Jermiin LS, Hunt NH. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 2007;396:203-213
• Maghzal G, Stocker R. Improved analysis of hydroethidine and 2-hydroxyethidium by HPLC and electrochemical detection. Free Radic Biol Med 2007;43:1095-1096
• Stocker R. Vitamin E. In Dietary Supplements and Health. Novartis Foundation Symposium 282. Eds. Bock G, Goode J (John Wiley & Sons, Chichester, U.K.) 2007; pp.77-92
• Minquin R, En H, Beck K, Rajendran R, Wu BJ, Halliwell B, Watt F, Stocker R. Nuclear microprobe investigation into the trace elemental contents of carotid artery walls of apolipoprotein E deficient mice. Nucl Instr and Meth B 2007;260:240-244
• Hunt NH, Stocker R. Heme moves to center stage in cerebral malaria. Nat Med 2007;13:667-669

• Lau AK, Chafour X, McLachlan C, Leichtweis, Steven B, Celermajer DS, Sullivan C, Stocker R. Intimal thickening after arterial balloon injury is increased by repetitive hypoxia but repetitive hyperoxia is not protective. Atherosclerosis 2006;185:254-263
• Stocker R, Pollicino C, Gay CA, Nestel P, Colquhoun D, Whiting M, Tonkin A, Sullivan D, Simes J. Neither plasma coenzyme Q10 concentration, nor its decline during statin therapy, is linked to recurrent cardiovascular disease events: A prospective case-control study from the LIPID study. Atherosclerosis 2006;197:198-204
• Parker G, Heruc GA, Hilton TM, Olley A, Brotchie H, Hadzi-Pavlovic D, Friend C, Walsh WF, Stocker R. Low levels of docosahexaenoic acid in depressed patients with coronary artery disease. Psychiatry Res 2006;141:279-286
• Hack B, Witting PK, Rayner BS, Stocker R, Headrick JP. The relation between myocardial dysfunction and oxidant stress and damage in ischemic-reperfused mouse hearts: effects of adenosine and pyruvate. Mol Cell Biochem 2006;287:165-175
• Tanous DJ, Bräsen JH, Choy K, Wu BJ, Kathir K, Lau A, Celermajer DS, Stocker R. Probucol promotes re-endothelialization and inhibits in-stent neointimal hyperplasia and thrombosis. Atherosclerosis 2006;189:342-349
• de Haan JB, Stefanovic N, Witting PK, Daskalakis M, Kola I, Stocker R, Smolich JJ. Lack of the antioxidant enzyme glutathione peroxidase-1 (Gpx1) does not lead to increased atherosclerosis in mice fed a high fat diet. J Lipid Res 2006;47:1157-1167
• Wu BJ, Kathir K, Witting PK, Beck K, Choy K, Li C, Croft KD, Mori TA, Tanous D, Adams MR, Lau AK, Stocker R. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med 2006;203:1117-1127
• Suarna C, Cynshi O, Stocker R. Protective effect of vitamin E supplements on experimental atherosclerosis is modest and dependent on pre-existing vitamin E deficiency. Free Radic Biol Med 2006;41:722-730
• Skilton MR, Gosby AK, Wu BJ, Ho LML, Stocker R, Caterson ID, Celermajer DS. Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial function. Clin Sci 2006;114:281-287
• Witting PK, Harris HH, Rayner BS, Aitken JB, Dillon CT, Stocker R, Lai B, Cai Z, Lay PA. Hydrogen peroxide promotes metal ion efflux in aortic endothelial cells: Elemental mapping by hard X-ray microprobe. Biochemistry 2006;45:12500-12509
• Stocker R, Perrella MA. Heme oxygenase 1: A novel drug target for atherosclerotic diseases? Circulation 2006;114:2178-2189

• Yamauchi R, Southwell-Keely P, Suarna C, Ray S, Raftery M, Cynshi O, Stocker R. Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma. Free Radic Biol Med 2005;38:32-40
• Rayner BS, Wu BJ, Raftery M, Stocker R, Witting PK. Human S-nitroso-myoglobin is a store of vasoactive nitric oxide. J Biol Chem 2005;280:9985-9993
• Witting PK, Wu BJ, Raftery M, Southwell-Keely P, Stocker R. Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate. J Biol Chem 2005;280:15612-15618
• Choy K, Beck K, Png FY, Leichtweis SB, Wu BJ, Thomas SR, Hou JY, Croft KD, Mori TA, Stocker R. Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice. Arterioscl Thromb Vasc Biol 2005;25:1684-1690
• Panzenböck U, Stocker R. Formation of methionine sulfoxide-containing specific forms of oxidized high-density lipoproteins. Biochim Biophys Acta 2005;1703:171-181
• Dallner G, Stocker R. Coenzyme Q10. In Encyclopedia of Dietary Supplements. Eds. Coates P, Blackman MR, Cragg G, Levine M, Moss J, White P (Marcel Dekker, New York) 2005;121-131
• Stocker R, Keaney JF, Jr. New insights on oxidative stress in the artery wall. J Thromb Haemostasis 2005;3:1825-1834
• Stocker R, Keaney JF, Jr. Chapter 5: Oxidative stress and atherosclerosis. In Molecular mechanisms of atherosclerosis. Ed. Loscalzo J (Taylor & Francis, Lancaster) 2005; pp. 61-83
• Cynshi O, Stocker R. Inhibition of lipoprotein lipid oxidation. In Handbook of Experimental Pharmacology. Vol. 170. Atherosclerosis: diet and drugs. Ed. Von Eckardstein A (Springer-Verlag, Berlin, Germany) 2005; pp. 563-590
• Stocker R. Antioxidant defense mechanisms by heme oxygenase and bile pigments. In Heme oxygenase: The elegant orchestration of its products in medicine. Eds. Otterbein LE, Zuckerbraun BS (Nova Biomedical Books, New York, NY) 2005; pp. 313-331

• Stocker R, O’Halloran RA. De-alcoholized red wine decreases atherosclerosis in apolipoprotein E gene-deficient mice independent of inhibition of lipid peroxidation in the artery wall. Am J Clin Nutr 2004;79:123-130
• Wang XL, Rainwater D, Mahaney M, Stocker R. Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons. Am J Clin Nutr 2004;80:649-655
• Gay CA, Stocker R. Simultaneous determination of coenzyme Q10, cholesterol and major cholesterylesters in human blood plasma. In Quinones and Quinone Enzymes - Methods in Enzymology. Eds, Sies H and Packer L (Academic, Orlando) 2004;378:162-169
• Rayner BS, Stocker R, Lay PA, Witting PK. Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide. Tyrosine residue 103 affects rate and product distribution. Biochem J 2004;81:365-372
• Aitken JB, Thomas SE, Stocker R, Thomas SR, Takikawa, O, Armstrong RS, Lay PA. Determination of the nature of the heme environment in nitrosyl indoleamine 2,3dioxygenase using multiple-scattering analyses of XAFS. Biochemistry 2004,43:4892-4898
• Deng YM, Wu B, Witting PK, Stocker R. Probucol protects against smooth muscle cell proliferation by up-regulating heme oxygenase-1. Circulation 2004;110:1861-1866
• Stocker R, Keaney JF, Jnr. The role of oxidative modifications in atherosclerosis. Physiol Rev 2004;84:1381-1478
• Kontush A, Chapman MJ, Stocker R. Vitamin E is not deficient in human atherosclerotic plaques. Arterioscl Thromb Vasc Biol 2004;24:e139-e140
• Stocker R, Huang A, Jeranian E, Hou JY, Wu T, Thomas SR, Keaney JF, Jr. Hypochlorous acid impairs EDNO bioactivity through a superoxide-dependent mechanism. Arterioscl Thromb Vasc Biol 2004;24:2028-2033
• Rayner BS, Wu BJ, Raftery M, Stocker R, Witting PK. Regulation of vascular tone by S-nitroso-myoglobin. Redox Report 2004;9:382-386
• Jessup W, Kritharides L, Stocker R. Lipid oxidation in atherogenesis: an overview. Biochem Soc Trans 2004;32:134-138
• Stocker R. Antioxidant activities of bile pigments. Antiox Redox Signal 2004;6:841-849
• Witting PK, Stocker R. Ascorbic acid in atherosclerosis. In Vitamin C. Eds, Asard H, May JM, Smirnoff N (BIOS Scientific Publishers, Oxford) 2004; pp. 261-290