The University of Sydney
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Dr Helen Ball

T: +61 2 9036 3238
F: +61 2 9036 3286
D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

Current national competitive grants

2009

Mechanisms of disease in Bacterial meningitis
NHMRC Project Grants $453,000 over 3 years

2008

Dysregulation of cytokine networks: a key determinant of the pathogenesis of cerebral malaria
NHMRC Project Grant $461,625 over 3 years

Publications

2010

Ball, H, Sanchez-Perez, A, Wieser, S, Austin, C, Astelbauer, F, Miu, J, McQuillan, J, Stocker, R, Jermiin, L, Hunt, N. Corrigendum to "Characterization of an indoliamine 2,3-dioxygenase-like protein found in humans and mice" [Gene (2007) 203-213]. Gene. 2010; :
Yuasa, H, Ball, H, Austin, C, Hunt, N. 1-l-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-d-methyltryptophan. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2010; :
Wang, Y, Liu, H, McKenzie, G, Witting, P, Stasch, J, Hahn, M, Changsirivathanathamrong, D, Wu, B, Ball, H, Thomas, S, Kapoor, V, Celermajer, D, Mellor, A, Keaney, J, Hunt, N, Stocker, R. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature medicine. 2010; 16:279-85
Austin, C, Mailu, B, Maghzal, G, Sanchez-Perez, A, Rahlfs, S, Zocher, K, Yuasa, H, Arthur, J, Becker, K, Stocker, R, Hunt, N, Ball, H. Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2. Amino acids. 2010; :

2009

Yuasa, H, Ball, H, Ho, Y, Austin, C, Whittington, C, Belov, K, Maghzal, G, Jermiin, L, Hunt, N. Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2009; 153:137-144
Ball, H, Yuasa, H, Austin, C, Weiser, S, Hunt, N. Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. The international journal of biochemistry & cell biology. 2009; 41:467-71
Miu, J, Ball, H, Mellor, A, Hunt, N. Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. International journal for parasitology. 2009; 39:363-70
Austin, C, Astelbauer, F, Kosim-Satyaputra, P, Ball, H, Willows, R, Jamie, J, Hunt, N. Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino acids. 2009; 36:99-106

2008

Miu, J, Hunt, N, Ball, H. Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infection and Immunity. 2008; 76:1812-1824
Miu, J, Mitchell, A, Müller, M, Carter, S, Manders, P, McQuillan, J, Saunders, B, Ball, H, Lu, B, Campbell, I, Hunt, N. Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of immunology. 2008; 180:1217-30

2007

Ball, H, Sanchez-Perez, A, Weiser, S, Austin, C, Astelbauer, F, Miu, J, McQuillan, J, Stocker, R, Jermiin, L, Hunt, N. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene. 2007; 396:203-213
Weiser, S, Miu, J, Ball, H, Hunt, N. Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine. 2007; 37:84-91

2006

Hunt, N, Golenser, J, Chan-Ling, T, Parekh, S, Rae, C, Potter, S, Medana, I, Miu, J, Ball, H. Immunopathogenesis of cerebral malaria. International journal for parasitology. 2006; 36:569-582
Potter, S, Chan-Ling, T, Ball, H, Mansour, H, Mitchell, A, Maluish, L, Hunt, N. Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International journal for parasitology. 2006; 36:485-96
Potter, S, Chan-Ling, T, Rosinova, E, Ball, H, Mitchell, A, Hunt, N. A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of neuroimmunology. 2006; 173:96-107

2005

Mitchell, A, Hansen, A, Hee, L, Ball, H, Potter, S, Walker, J, Hunt, N. Early cytokine production is associated with protection from murine cerebral malaria. Infection and immunity. 2005; 73:5645-53

2004

Hansen, A, Ball, H, Mitchell, A, Miu, J, Takikawa, O, Hunt, N. Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. International journal for parasitology. 2004; 34:1309-19
Ball, H, Hunt, N. Needle in a haystack: microdissecting the proteome of a tissue. Amino acids. 2004; 27:1-7
Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004; 18:499-510
Ball, H, MacDougall, H, McGregor, I, Hunt, N. Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. The Journal of infectious diseases. 2004; 189:751-8

2003

Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. Faseb Journal. 2003; 18:499-510

2002

Ball, H, McParland, B, Driussi, C, Hunt, N. Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain research. Brain research protocols. 2002; 9:206-13
Borgland, S, Connor, M, Ryan, R, Ball, H, Christie, M. Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of physiology. 2002; 539:433-44
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