Professor Nicholas Hunt

E:  nicholas.hunt@bosch.org.au T:  +61 2 9036 3242 F:  +61 2 9035 3286 K25 - Medical Foundation Building The University of Sydney NSW 2006 Australia

• Biographical details
• Research interests
• Competitive grants
• Publications

Biographical details

Research interests

Current national competitive grants

Publications

2010

Ball, H, Sanchez-Perez, A, Wieser, S, Austin, C, Astelbauer, F, Miu, J, McQuillan, J, Stocker, R, Jermiin, L, Hunt, N. Corrigendum to "Characterization of an indoliamine 2,3-dioxygenase-like protein found in humans and mice" [Gene (2007) 203-213]. Gene. 2010; :

Mitchell, A, Pradel, L, Chasson, L, Van Rooijen, N, Grau, G, Hunt, N, Chimini, G. Technical Advance: Autofluorescence as a tool for myeloid cell analysis. Journal of leukocyte biology. 2010; :

Combes, V, El-Assaad, F, Faille, D, Jambou, R, Hunt, N, Grau, G. Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis. Progress in neurobiology. 2010; 91:140-51

Hunt, N, Grau, G, Engwerda, C, Barnum, S, van der Heyde, H, Hansen, D, Schofield, L, Golenser, J. Murine cerebral malaria: the whole story. Trends in parasitology. 2010. p. 272-4.

Yuasa, H, Ball, H, Austin, C, Hunt, N. 1-l-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-d-methyltryptophan. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2010; :

Wang, Y, Liu, H, McKenzie, G, Witting, P, Stasch, J, Hahn, M, Changsirivathanathamrong, D, Wu, B, Ball, H, Thomas, S, Kapoor, V, Celermajer, D, Mellor, A, Keaney, J, Hunt, N, Stocker, R. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature medicine. 2010; 16:279-85

Austin, C, Mailu, B, Maghzal, G, Sanchez-Perez, A, Rahlfs, S, Zocher, K, Yuasa, H, Arthur, J, Becker, K, Stocker, R, Hunt, N, Ball, H. Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2. Amino acids. 2010; :

2009

Krimmer, D, Loseli, M, Hughes, J, Oliver, B, Moir, L, Hunt, N, Black, J, Burgess, J. CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy. 2009; 64:1074-82

Yuasa, H, Ball, H, Ho, Y, Austin, C, Whittington, C, Belov, K, Maghzal, G, Jermiin, L, Hunt, N. Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2009; 153:137-144

Ball, H, Yuasa, H, Austin, C, Weiser, S, Hunt, N. Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. The international journal of biochemistry & cell biology. 2009; 41:467-71

Miu, J, Ball, H, Mellor, A, Hunt, N. Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. International journal for parasitology. 2009; 39:363-70

Austin, C, Astelbauer, F, Kosim-Satyaputra, P, Ball, H, Willows, R, Jamie, J, Hunt, N. Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino acids. 2009; 36:99-106

2008

Xu, Y, Hunt, N, Bao, S. The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation. Cell research. 2008; 18:1220-9

Belnoue, E, Potter, S, Rosa, D, Mauduit, M, Grüner, A, Kayibanda, M, Mitchell, A, Hunt, N, Rénia, L. Control of pathogenic CD8+ T cell migration to the brain by IFN-gamma during experimental cerebral malaria. Parasite Immunology. 2008; 30:544-553

Burgess, J, Lee, J, Ge, Q, Ramsay, E, Poniris, M, Parmentier, J, Roth, M, Johnson, P, Hunt, N, Black, J, Ammit, A. Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma. Journal of cellular physiology. 2008; 216:673-9

Xu, Y, Hunt, N, Bao, S. The effect of restraint stress on experimental colitis is IFN-gamma independent. Journal of neuroimmunology. 2008; 200:53-61

Maghzal, G, Thomas, S, Hunt, N, Stocker, R. Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. Journal of Biological Chemistry. 2008; 283:12014-12025

Miu, J, Hunt, N, Ball, H. Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infection and Immunity. 2008; 76:1812-1824

Miu, J, Mitchell, A, Müller, M, Carter, S, Manders, P, McQuillan, J, Saunders, B, Ball, H, Lu, B, Campbell, I, Hunt, N. Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of immunology. 2008; 180:1217-30

2007

Ball, H, Sanchez-Perez, A, Weiser, S, Austin, C, Astelbauer, F, Miu, J, McQuillan, J, Stocker, R, Jermiin, L, Hunt, N. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene. 2007; 396:203-213

Hunt, N, Stocker, R. Heme moves to center stage in cerebral malaria. Nature medicine. 2007; 13:667-669

Weiser, S, Miu, J, Ball, H, Hunt, N. Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine. 2007; 37:84-91

Xu, Y, Hunt, N, Bao, S. The correlation between proinflammatory cytokines, MAdCAM-1 and cellular infiltration in the inflamed colon from TNF-alpha gene knockout mice. Immunology and cell biology. 2007; 85:633-9

2006

Golenser, J, Waknine, J, Krugliak, M, Hunt, N, Grau, G. Current perspectives on the mechanism of action of artemisinins. International journal for parasitology. 2006; 36:1427-41

Parekh, S, Bubb, W, Hunt, N, Rae, C. Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malaria. International journal for parasitology. 2006; 36:1409-18

Rae, C, Moussa, C, Griffin, J, Parekh, S, Bubb, W, Hunt, N, Balcar, V. A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006; 26:1005-17

Okada, F, Kobayashi, M, Tanaka, H, Kobayashi, T, Tazawa, H, Iuchi, Y, Onuma, K, Hosokawa, M, Dinauer, M, Hunt, N. The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. American journal of pathology. 2006; 169:294-302

Hunt, N, Grau, G. Blood-brain barrier in parasitic disease. International journal for parasitology. 2006; 36:503-4

Golenser, J, McQuillan, J, Hee, L, Mitchell, A, Hunt, N. Conventional and experimental treatment of cerebral malaria. International journal for parasitology. 2006; 36:583-93

Hunt, N, Golenser, J, Chan-Ling, T, Parekh, S, Rae, C, Potter, S, Medana, I, Miu, J, Ball, H. Immunopathogenesis of cerebral malaria. International journal for parasitology. 2006; 36:569-582

Potter, S, Chan-Ling, T, Ball, H, Mansour, H, Mitchell, A, Maluish, L, Hunt, N. Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International journal for parasitology. 2006; 36:485-96

Potter, S, Chan-Ling, T, Rosinova, E, Ball, H, Mitchell, A, Hunt, N. A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of neuroimmunology. 2006; 173:96-107

Golenser, J, Hunt, N. Probing for antiparasitic drugs. Mini reviews in medicinal chemistry. 2006; 6:121-2

2005

Mitchell, A, Hansen, A, Hee, L, Ball, H, Potter, S, Walker, J, Hunt, N. Early cytokine production is associated with protection from murine cerebral malaria. Infection and immunity. 2005; 73:5645-53

Potter, S, Mitchell, A, Cowden, W, Sanni, L, Dinauer, M, de Haan, J, Hunt, N. Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. Infection and immunity. 2005; 73:4941-7

Parekh, S, Moussa, C, Balcar, V, Hunt, N, Bubb, W, Rae, C. Quinolinic acid, kynurenic acid and dserine stimulate brain metabolism. Journal of Neurochemistry. 2005; 94:58-58

Burgess, J, Blake, A, Boustany, S, Johnson, P, Armour, C, Black, J, Hunt, N, Hughes, J. CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle. The Journal of allergy and clinical immunology. 2005; 115:302-308

Combes, V, De Souza, J, Rénia, L, Hunt, N, Grau, G. Cerebral malaria: Which parasite? Which model?. Drug Discovery Today: Disease Models. 2005; 2:141-147

Becker, K, Koncarevic, S, Hunt, N. Oxidative stress and antioxidant defense in malarial parasites. In: Molecular approaches to malaria. Washington DC, USA: American Society for Microbiology Press 2005. p. 365-383.

2004

Hardy, K, Hunt, N. Effects of a redox-active agent on lymphocyte activation and early gene expression patterns. Free radical biology & medicine. 2004; 37:1550-63

Hansen, A, Ball, H, Mitchell, A, Miu, J, Takikawa, O, Hunt, N. Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. International journal for parasitology. 2004; 34:1309-19

Ball, H, Hunt, N. Needle in a haystack: microdissecting the proteome of a tissue. Amino acids. 2004; 27:1-7

Burgess, J, Carlin, S, Pack, R, Arndt, G, Au, W, Johnson, P, Black, J, Hunt, N. Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma?. The Journal of allergy and clinical immunology. 2004; 113:683-9

Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004; 18:499-510

Ball, H, MacDougall, H, McGregor, I, Hunt, N. Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. The Journal of infectious diseases. 2004; 189:751-8

Rogerson, S, Grau, G, Hunt, N. The microcirculation in severe malaria. Microcirculation (New York, N.Y. : 1994). 2004; 11:559-76

2003

Medana, I, Day, N, Salahifar-Sabet, H, Stocker, R, Smythe, G, Bwanaisa, L, Njobvu, A, Kayira, K, Turner, G, Taylor, T, Hunt, N. Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria. The Journal of infectious diseases. 2003; 188:844-9

Hunt, N, Grau, G. Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends in immunology. 2003; 24:491-9

Lau, A, Leichtweis, S, Hume, P, Mashima, R, Hou, J, Chaufour, X, Wilkinson, B, Hunt, N, Celermajer, D, Stocker, R. Probucol promotes functional reendothelialization in balloon-injured rabbit aortas. Circulation. 2003; 107:2031-6

Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. Faseb Journal. 2003; 18:499-510

2002

Ball, H, McParland, B, Driussi, C, Hunt, N. Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain research. Brain research protocols. 2002; 9:206-13

Medana, I, Hien, T, Day, N, Phu, N, Mai, N, Chu'ong, L, Chau, T, Taylor, A, Salahifar, H, Stocker, R, Smythe, G, Turner, G, Farrar, J, White, N, Hunt, N. The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria. The Journal of infectious diseases. 2002; 185:650-6

Pack, R, Hardy, K, Madigan, M, Hunt, N. Differential effects of the antioxidant alpha-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells. Molecular immunology. 2002; 38:733-45

2001

Sanni, L, Rae, C, Maitland, A, Stocker, R, Hunt, N. Is ischemia involved in the pathogenesis of murine cerebral malaria?. The American journal of pathology. 2001; 159:1105-12

Thomas, S, Salahifar, H, Mashima, R, Hunt, N, Richardson, D, Stocker, R. Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate. Journal of immunology (Baltimore, Md. : 1950). 2001; 166:6332-40

Lee, J, Johnson, P, Roth, M, Hunt, N, Black, J. ERK activation and mitogenesis in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 2001; 280:L1019-29

Medana, I, Chaudhri, G, Chan-Ling, T, Hunt, N. Central nervous system in cerebral malaria: 'Innocent bystander' or active participant in the induction of immunopathology?. Immunology and cell biology. 2001; 79:101-20

Hunt, N, Driussi, C, Sai-Kiang, L. Haptoglobin and malaria. Redox report : communications in free radical research. 2001; 6:389-92

Potter, S, Sanni, L, Simasathiansophon, S, Dinauer, M, Hunt, N. Phagocyte-derived reactive oxygen species and the immunology and pathology of murine malaria. Redox report : communications in free radical research. 2001; 6:200-3

van Reyk, D, King, N, Dinauer, M, Hunt, N. The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes. Free radical biology & medicine. 2001; 30:82-8

Amis, T, Bredemeyer, S, Byrne, M, Catt, J, Chen, J, Green, B, Henderson-Smart, D, Hunt, N, Hyde, C, Pajkos, A, Schmid, H. Recent advances in the design and performance of research assistants. Redox report : communications in free radical research. 2001; 6:215-7

Medana, I, Chaudhri, G, Chan-Ling, T, Hunt, N. Cenral nervous system in cerebral malaria: 'Innocent bystander' or active participant in the induction of immunopathology?. Immunology and Cell Biology. 2001; 28:1044-1047

Pack, R, Hardy, K, Madigan, M, Hunt, N. Differential effects of the antioxidant a-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells. Molecular Immunology. 2001; 42(3):220-221

2000

van Reyk, D, Sarel, S, Hunt, N. Inhibition of in vitro lymphoproliferation by three novel iron chelators of the pyridoxal and salicyl aldehyde hydrazone classes. Biochemical Pharmacology. 2000; 60:581-587

Karupiah, G, Hunt, N, King, N, Chaudhri, G. NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response. Reviews in Immunogenetics. 2000; 2:387-415

Rae, C, Maitland, D, Bubb, W, Hunt, N. Dichloroacetate (DCA) reduces brain lactate but increases brain glutamine in experimental cerebral malaria: a 1H-NMR study. Redox Report. 2000; 5:141-143

Medana, I, Chan-Ling, T, Hunt, N. Reactive changes in retinal microglia during fatal murine cerebral malaria. American Journal of Pathology. 2000; 156:1055-1065

Hardy, K, Pack, R, Hunt, N. Redox regulation of gene expression in mitogen-activated T lymphocytes. In: Free Radicals in Chemistry, Biology and Medicine. : OICA International 2000. p. 159-171.