Professor Iain L. Campbell

T:  +61 2 9351 4676 F:  +61 2 9351 5858  Personal Homepage G08 - Biochemistry Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Ellis, S, Gysbers, V, Manders, P, Li, W, Hofer, M, M��ller, M, Campbell, I. The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-{gamma} in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1. Journal of immunology (Baltimore, Md. : 1950). 2010; :

M��ller, M, Carter, S, Hofer, M, Campbell, I. The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum. Neuropathology and applied neurobiology. 2010; :

Hofer, M, Li, W, Lim, S, Campbell, I. The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010; 30:1149-1157

Thompson, C, Hofer, M, Campbell, I, Holmes, A. Community dynamics in the mouse gut microbiota: a possible role for IRF9-regulated genes in community homeostasis. PloS one. 2010; 5:e10335

2009

Feuer, R, Ruller, C, An, N, Tabor-Godwin, J, Rhoades, R, Maciejewski, S, Pagarigan, R, Cornell, C, Crocker, S, Kiosses, W, Pham-Mitchell, N, Campbell, I, Whitton, J. Viral persistence and chronic immunopathology in the adult CNS following coxsackievirus infection during the neonatal period. Journal of virology. 2009; 83:9356-69

Quintana, A, M��ller, M, Frausto, R, Ramos, R, Getts, D, Sanz, E, Hofer, M, Krauthausen, M, King, N, Hidalgo, J, Campbell, I. Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. Journal of Immunology. 2009; 183:2079-2088

2008

Hofer, M, Carter, S, Müller, M, Campbell, I. Unaltered Neurological Disease and Mortality in CXCR3-Deficient Mice Infected Intracranially with Lymphocytic Choriomeningitis Virus-Armstrong. Viral Immunology. 2008; 21:425-433

Getts, D, Terry, R, Getts, M, Müller, M, Rana, S, Shrestha, B, Radford, J, Van Rooijen, N, Campbell, I, King, N. Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. The Journal of experimental medicine. 2008; 205:2319-37

Wang, J, Campbell, I, Zhang, H. Systemic interferon-alpha regulates interferon-stimulated genes in the central nervous system. Molecular psychiatry. 2008; 13:293-301

Quintana, A, Molinero, A, Borup, R, Nielsen, F, Campbell, I, Penkowa, M, Hidalgo, J. Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Developmental neurobiology. 2008; 68:195-208

Miu, J, Mitchell, A, Müller, M, Carter, S, Manders, P, McQuillan, J, Saunders, B, Ball, H, Lu, B, Campbell, I, Hunt, N. Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of immunology. 2008; 180:1217-30

Sanz, E, Hofer, M, Unzeta, M, Campbell, I. Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain. Glia. 2008; 56:190-199

2007

Carter, S, Müller, M, Manders, P, Campbell, I. Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro. Glia. 2007; 55:1728-39

Getts, D, Matsumoto, I, Müller, M, Getts, M, Radford, J, Shrestha, B, Campbell, I, King, N. Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures. Journal of neurochemistry. 2007; 103:1019-30

Quintana, A, Molinero, A, Florit, S, Manso, Y, Comes, G, Carrasco, J, Giralt, M, Borup, R, Nielsen, F, Campbell, I, Penkowa, M, Hidalgo, J. Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior. Journal of neuroscience research. 2007; 85:2668-85

Müller, M, Carter, S, Hofer, M, Manders, P, Getts, D, Getts, M, Dreykluft, A, Lu, B, Gerard, C, King, N, Campbell, I. CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. Journal of immunology (Baltimore, Md. : 1950). 2007; 179:2774-2786

Millward, J, Caruso, M, Campbell, I, Gauldie, J, Owens, T. IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system. Journal of immunology (Baltimore, Md. : 1950). 2007; 178:8175-8182

Wacher, C, Müller, M, Hofer, M, Getts, D, Zabaras, R, Ousman, S, Terenzi, F, Sen, G, King, N, Campbell, I. Co-ordinate regulation and widespread cellular expression of the interferon stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of virology. 2007; 81:860-71

Hofer, M, Mueller, M, OSullivan, C, Manders, P, Campbell, I. Lethal lymphocytic choriomeningitis virus (LCMV) infection in STAT1 KO mice is associated with dysregulated PD-1/B7-H1 and a phenotypic switch in the T-cell response. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 2007; 27:696-696

Campbell, I, Iglesias, E, Unzeta, M. STAT1 has a minimal role in interleukin-6 signalling and actions in the murine brain. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 2007; 27:722-722

2006

Milner, R, Campbell, I. Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system. Molecular and cellular neurosciences. 2006; 33:429-40

Crocker, S, Whitmire, J, Frausto, R, Chertboonmuang, P, Soloway, P, Whitton, J, Campbell, I. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. American Journal of Pathology. 2006; 169:2104-2116

Crocker, S, Milner, R, Pham-Mitchell, N, Campbell, I. Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells. Journal of Neurochemistry. 2006; 98:812-823

Zirger, J, Barcia, C, Liu, C, Puntel, M, Mitchell, N, Campbell, I, Castro, M, Lowenstein, P. Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 10(8) international units, but not lower doses, of adenoviral vectors into the brain. Journal of Virology. 2006; 80:5655-5659

Carr, D, Campbell, I. Herpes simplex virus type 1 induction of chemokine production is unrelated to viral load in the cornea but not in the nervous system. Viral immunology. 2006; 19:741-6

2005

Reiman, R, Campos Torres, A, Martin, B, Ting, J, Campbell, I, Barnum, S. Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis. Neuroscience letters. 2005; 390:134-138

Wang, J, Campbell, I. Innate STAT1-dependent genomic response of neurons to the antiviral cytokine alpha interferon. Journal of virology. 2005; 79:8295-8302

Carr, D, Tomanek, L, Silverman, R, Campbell, I, Williams, B. RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2. Journal of virology. 2005; 79:9341-9345

Ousman, S, Wang, J, Campbell, I. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. Journal of virology. 2005; 79:7514-27

Balosso, S, Ravizza, T, Perego, C, Peschon, J, Campbell, I, De Simoni, M, Vezzani, A. Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. Annals of Neurology. 2005; 57:804-812

Campbell, I. Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS. Brain research. Brain research reviews. 2005; 48:166-177

Ousman, S, Campbell, I. Regulation of murine interferon regulatory factor gene expression in the central nervous system determined by multiprobe RNase protection assay. Methods in molecular medicine. 2005; 116:115-134

2004

Wang, J, Lin, W, Popko, B, Campbell, I. Inducible production of interferon-gamma in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway. Molecular and cellular neurosciences. 2004; 27:489-96

Lin, W, Kemper, A, McCarthy, K, Pytel, P, Wang, J, Campbell, I, Utset, M, Popko, B. Interferon-gamma induced medulloblastoma in the developing cerebellum. The Journal of neuroscience. 2004; 24:10074-10083

Boos, L, Campbell, I, Ames, R, Wetsel, R, Barnum, S. Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis. Journal of Immunology. 2004; 173:4708-4714

Vlkolinský, R, Siggins, G, Campbell, I, Krucker, T. Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices. Journal of Neuroimmunology. 2004; 150:37-47

Sitia, G, Isogawa, M, Iannacone, M, Campbell, I, Chisari, F, Guidotti, L. MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. The Journal of Clinical Investigation. 2004; 113:1158-1167

Sánchez-Alavez, M, Gombart, L, Huitrón-Reséndiz, S, Carr, J, Wills, D, Berg, G, Campbell, I, Gauvin, D, Henriksen, S, Criado, J. Physiological and behavioral effects of methamphetamine in a mouse model of endotoxemia: a preliminary study. Pharmacology, biochemistry, and behavior. 2004; 77:365-370

Sánchez-Burgos, G, Hernández-Pando, R, Campbell, I, Ramos-Castañeda, J, Ramos, C. Cytokine production in brain of mice experimentally infected with dengue virus. Neuroreport. 2004; 15:37-42

Crocker, S, Pagenstecher, A, Campbell, I. The TIMPs tango with MMPs and more in the central nervous system. Journal of neuroscience research. 2004; 75:1-11

Campbell, I. Chemokines as plurifunctional mediators in the CNS: implications for the pathogenesis of stroke. Ernst Schering Research Foundation workshop. 2004; 45:31-51

2003

Kayali, A, Van Gunst, K, Campbell, I, Stotland, A, Kritzik, M, Liu, G, Flodström-Tullberg, M, Zhang, Y, Sarvetnick, N. The stromal cell-derived factor-1alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. The Journal of cell biology. 2003; 163:859-869

Moore, T, Moore, J, Kaji, Y, Frizzell, N, Usui, T, Poulaki, V, Campbell, I, Stitt, A, Gardiner, T, Archer, D, Adamis, A. The role of advanced glycation end products in retinal microvascular leukostasis. Investigative ophthalmology & visual science. 2003; 44:4457-4464

Penkowa, M, Camats, J, Hadberg, H, Quintana, A, Rojas, S, Giralt, M, Molinero, A, Campbell, I, Hidalgo, J. Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. Journal of neuroscience research. 2003; 73:481-496

Wang, J, Pham-Mitchell, N, Schindler, C, Campbell, I. Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain. The Journal of clinical investigation. 2003; 112:535-43

Samland, H, Huitron-Resendiz, S, Masliah, E, Criado, J, Henriksen, S, Campbell, I. Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. Journal of neuroscience research. 2003; 73:176-87

Carrasco, J, Penkowa, M, Giralt, M, Camats, J, Molinero, A, Campbell, I, Palmiter, R, Hidalgo, J. Role of metallothionein-III following central nervous system damage. Neurobiology of disease. 2003; 13:22-36

Penkowa, M, Camats, J, Giralt, M, Molinero, A, Hernández, J, Carrasco, J, Campbell, I, Hidalgo, J. Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia. 2003; 42:287-306

Milner, R, Campbell, I. The extracellular matrix and cytokines regulate microglial integrin expression and activation. Journal of immunology (Baltimore, Md. : 1950). 2003; 170:3850-8

Lewicki, H, Tishon, A, Homann, D, Mazarguil, H, Laval, F, Asensio, V, Campbell, I, DeArmond, S, Coon, B, Teng, C, Gairin, J, Oldstone, M. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies. Journal of virology. 2003; 77:3799-3808

Molinero, A, Penkowa, M, Hernández, J, Camats, J, Giralt, M, Lago, N, Carrasco, J, Campbell, I, Hidalgo, J. Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6. Journal of neuropathology and experimental neurology. 2003; 62:315-328

2002

Wang, J, Schreiber, R, Campbell, I. STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99:16209-14

Milner, R, Campbell, I. Developmental regulation of beta1 integrins during angiogenesis in the central nervous system. Molecular and cellular neurosciences. 2002; 20:616-26

2001

Pagenstecher, A, Wussler, E, Opdenakker, G, Volk, B, Campbell, I. Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors. Journal of neuropathology and experimental neurology. 2001; 60:598-612

Giralt, M, Carrasco, J, Penkowa, M, Morcillo, M, Santamaría, J, Campbell, I, Hidalgo, J. Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain. Experimental neurology. 2001; 168:334-46

Asensio, V, Campbell, I. Chemokines and viral diseases of the central nervous system. Advances in virus research. 2001; 56:127-73