Professor Nicholas King

E:  nicholas.king@bosch.org.au T:  +61 2 9351 4553 F:  +61 2 9351 3429 D06 - Blackburn Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Trian, T, Ge, Q, Moir, L, Burgess, J, Kuo, C, King, N, Reddel, H, Black, J, Oliver, B, McParland, B. Rhinovirus-induced Exacerbations of Asthma - How is the {beta}2-adrenoceptor Implicated?. American journal of respiratory cell and molecular biology. 2010; 43:227-33

2009

Kashem, M, Sarker, R, Des Etages, H, Machaalani, R, King, N, McGregor, I, Matsumoto, I. Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry international. 2009; 55:483-90

Quintana, A, M��ller, M, Frausto, R, Ramos, R, Getts, D, Sanz, E, Hofer, M, Krauthausen, M, King, N, Hidalgo, J, Campbell, I. Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. Journal of Immunology. 2009; 183:2079-2088

King, N, Davison, A, Getts, D, Lu, D, Getts, M, Yeung, A, Peterson, J, Kesson, A. Enhanced Antigen Processing or Immune Evasion? West Nile Virus and the Induction of Immune Recognition Molecules. In: West Nile Encephalitis Virus Infection. United States: Springer 2009. p. 309-339.

2008

Patel, M, Singh, J, Niknami, M, Kurek, C, Yao, M, Lu, S, Maclean, F, King, N, Gelb, M, Scott, K, Russell, P, Boulas, J, Dong, Q. Cytosolic Phospholipase A2-{alpha}: A Potential Therapeutic Target for Prostate Cancer. Clinical Cancer Research. 2008; 14:8070-8079

Getts, D, Terry, R, Getts, M, Müller, M, Rana, S, Shrestha, B, Radford, J, Van Rooijen, N, Campbell, I, King, N. Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. The Journal of experimental medicine. 2008; 205:2319-37

Oliver, B, Lim, S, Wark, P, Laza-Stanca, V, King, N, Black, J, Burgess, J, Roth, M, Johnston, S. Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax. 2008; 63:519-25

Getts, D, Balcar, V, Matsumoto, I, Müller, M, King, N. Viruses and the immune system: their roles in seizure cascade development. Journal of neurochemistry. 2008; 104:1167-1176

2007

Getts, D, Matsumoto, I, Müller, M, Getts, M, Radford, J, Shrestha, B, Campbell, I, King, N. Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures. Journal of neurochemistry. 2007; 103:1019-30

Müller, M, Carter, S, Hofer, M, Manders, P, Getts, D, Getts, M, Dreykluft, A, Lu, B, Gerard, C, King, N, Campbell, I. CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. Journal of immunology (Baltimore, Md. : 1950). 2007; 179:2774-2786

Kunzelmann, K, Sun, J, Meanger, J, King, N, Cook, D. Inhibition of airway Na+ transport by respiratory syncytial virus. Journal of virology. 2007; 81:3714-20

King, N, Thomas, S. Molecules in focus: Indoleamine 2,3-dioxygenase. The international journal of biochemistry & cell biology. 2007; 39:2167-72

Wacher, C, Müller, M, Hofer, M, Getts, D, Zabaras, R, Ousman, S, Terenzi, F, Sen, G, King, N, Campbell, I. Co-ordinate regulation and widespread cellular expression of the interferon stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of virology. 2007; 81:860-71

King, N, Getts, D, Getts, M, Rana, S, Shrestha, B, Kesson, A. Immunopathology of flavivirus infections. Immunology and cell biology. 2007; 85:33-42

2006

Jayasekera, J, Vinuesa, C, Karupiah, G, King, N. Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. The Journal of general virology. 2006; 87:3361-71

Oliver, B, Johnston, S, Baraket, M, Burgess, J, King, N, Roth, M, Lim, S, Black, J. Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respiratory research. 2006; 7:71

2005

Wu, W, Bao, S, King, N. Antiviral role for indoleamine 2,3-dioxygenase in vivo in vaginal infection by West Nile virus. Tissue Antigens. 2005; 66:464-464

Pamphlett, R, Kum-Jew, S, King, N. Flaviviruses in motor neuron disease. Muscle & nerve. 2005; 32:108-9

Chesher, D, Kay, J, King, N. Adding a reflective layer to a simulation-based learning environment. 12th International Conference on Artificial Intelligence in Education (AIED-2005). 2005; Amsterdam, The Netherlands, 18-22 July; 2005

Chesher, D, Kay, J, King, N. Simprac: supporting reflective learning within a new computer-based virtual patient simulator. 12th International Conference on Artificial Intelligence in Education (AIED 05) Workshop 11. 2005; Amsterdam, The Netherlands, 18-22 July; 2005

2004

Cheng, Y, King, N, Kesson, A. The role of tumor necrosis factor in modulating responses of murine embryo fibroblasts by flavivirus, West Nile. Virology. 2004; 329:361-70

Kunzelmann, K, König, J, Sun, J, Markovich, D, King, N, Karupiah, G, Young, J, Cook, D. Acute effects of parainfluenza virus on epithelial electrolyte transport. The Journal of biological chemistry. 2004; 279:48760-6

Sved, P, Scott, K, McLeod, D, King, N, Singh, J, Tsatralis, T, Nikolov, B, Boulas, J, Nallan, L, Gelb, M, Sajinovic, M, Graham, G, Russell, P, Dong, Q. Oncogenic action of secreted phospholipase A2 in prostate cancer. Cancer research. 2004; 64:6934-40

Arnold, S, Osvath, S, Hall, R, King, N, Sedger, L. Regulation of antigen processing and presentation molecules in West Nile virus-infected human skin fibroblasts. Virology. 2004; 324:286-96

Burke, S, Wen, L, King, N. Routes of inoculation and the immune response to a resolving genital flavivirus infection in a novel murine model. Immunology and cell biology. 2004; 82:174-83

Cheng, Y, King, N, Kesson, A. Major histocompatibility complex class I (MHC-I) induction by West Nile virus: involvement of 2 signaling pathways in MHC-I up-regulation. The Journal of infectious diseases. 2004; 189:658-68

2003

King, N, Kesson, A. Interaction of flaviviruses with cells of the vertebrate host and decoy of the immune response. Immunology and cell biology. 2003; 81:207-216

Haywood, M, Spaliviero, J, Jimemez, M, King, N, Handelsman, D, Allan, C. Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology. 2003; 144:509-517

King, N, Shrestha, B, Kesson, A. Immune modulation by flaviviruses. Advances in virus research. 2003; 60:121-55

van Haaften-Day, C, Russell, P, Davies, S, King, N, Tattersall, M. Expression of Fas and FasL in human serous ovarian epithelial tumors. Human pathology. 2003; 34:74-79

Chesher, D, Kay, J, King, N. A web-based virtual patient to support reflective learning. AIED2003: Supplementary Proceedings. 2003; Sydney NSW; 2003

2002

Madigan, M, Penfold, P, King, N, Billson, F, Conway, R. Immunoglobulin superfamily expression in primary retinoblastoma and retinoblastoma cell lines. Oncology research. 2002; 13:103-11

Penfold, P, Wen, L, Madigan, M, King, N, Provis, J. Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells. Investigative Ophthalmology & Visual Science. 2002; 43:3125-3130

Lu, D, Tian, L, O'Neill, C, King, N. Regulation of cellular adhesion molecule expression in murine oocytes, peri-implantation and post-implantation embryos. Cell Research. 2002; 12:373-383

Kesson, A, Cheng, Y, King, N. Regulation of Immune Recognition Molecules by Flavivirus, West Nile. Viral Immunology. 2002; 15:273-283

Chesher, D, Kay, J, King, N. Simprac - Teaching System for management of chronic illness. Adaptive Systems for Web-based Education Proceedings of the AH'2002 Workshop on Adaptive Systems for Web Based Education. 2002; Madrid Spain; 2002

2001

van Reyk, D, King, N, Dinauer, M, Hunt, N. The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes. Free radical biology & medicine. 2001; 30:82-8

Delikatny, E, van Holst Pellekaan, C, King, N. Autologous lymphocyte-monocyte co-culture increases NMR-visible and cytoplasmic lipids in the absence of increased markers of lymphocyte activation. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2001; 28:887-890

Ren, B, Sun, J, Hu, C, Zhang, L, King, N, Verran, D, Sheil, A. Immunosuppressive effects of tripterygium wilfordii hook f in a rat liver t5ansplant model. Transplantation Proceedings. 2001; 174(6):296-298

Byrne, S, Halliday, G, Johnson, L, King, N. Interleukin-1beta But not tumor necrosis factor is involved in West Nile Virus-Induced Langerhans Cell Migration from the Skin in C57BL/6 Mice. Journal of Investigative Dermatology. 2001; :

Byrne, S, Halliday, G, Johnston, L, King, N. Interleukin-1beta but not tumor necrosis factor is involved in West Nile virus-induced Langerhans cell migration from the skin in C57BL/6 mice. Journal of Investigative Dermatology. 2001; 55:793-800

Kesson, A, King, N. Transcriptional Regulaion of Major Histocompatibility Complex Class I by Flavivirus West Nile is dependent on NF-kB Activation. Journal of Infectious Diseases. 2001; 12:113-124

2000

Penfold, P, Wen, L, Madigan, M, Gillies, M, King, N, Provis, J. Triamcinolone acetonide modulates permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: implications for macular degeneration. Clinical and Experimental Immunology. 2000; 121:458-465

Yin, J, Chaufour, X, Mclachlan, C, McGuire, M, White, G, King, N, Hambly, B. Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo. Atherosclerosis. 2000; 148(2):365-374

Yin, J, Mclachlan, C, Chaufour, X, McGuire, M, White, G, Turner, V, King, N, Hambly, B. Growth arrest-specific gene 6 expression in proliferating rabbit vascular smooth muscle cells in vitro and in vivo. Electrophoresis. 2000; 21:3851-3856

Kunzelmann, K, Beesley, A, King, N, Karupiah, G, Young, J, Cook, D. Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia. Proceedings of the National Academy of Sciences. 2000; 97(18):10282-10287

Johnston, L, Halliday, G, King, N. Langerhans cells migrate to local lymph nodes following cutaneous infection with an arbovirus. Journal of Investigative Dermatology. 2000; 114:560-568

Johnson, L, Halliday, G, King, N. Langerhans cells migrate to local lymph nodes following cutaneous infection with an arbovirus. Journal of Investigative Dermatology. 2000; 114:560-568

Karupiah, G, Hunt, N, King, N, Chaudhri, G. NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response. Reviews in Immunogenetics. 2000; 2:387-415

King, N. Pretty in pink ... Redox Report. 2000; 5:11-13