Professor Judith Lee Black

T:  +61 2 9114 0342 F:  +61 2 9114 0399  Personal Homepage Woolcock Institute of Medical Research The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Ge, Q, Moir, L, Black, J, Oliver, B, Burgess, J. TGFbeta1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells-the role of SMAD2/3. Journal of cellular physiology. 2010; :

Lau, J, Oliver, B, Moir, L, Black, J, Burgess, J. Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells. Respirology. 2010; 15:303-312

Burgess, J, Boustany, S, Moir, L, Weckmann, M, Lau, J, Grafton, K, Baraket, M, Hansbro, P, Hansbro, N, Foster, P, Black, J, Oliver, B. Reduction of Tumstatin in Asthmatic Airways Contributes to Angiogenesis, Inflammation and Hyperresponsiveness. American journal of respiratory and critical care medicine. 2010; 181:106-15

2009

Black, J, Oliver, B, Roth, M. Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists. Chest. 2009; 136:1095-1100

Klagas, I, Goulet, S, Karakiulakis, G, Zhong, J, Baraket, M, Black, J, Papakonstantinou, E, Roth, M. Decreased hyaluronan in airway smooth muscle cells from patients with asthma and COPD. The European Respiratory Journal. 2009; 34:616-628

Black, J, Roth, M. Intrinsic asthma: is it intrinsic to the smooth muscle?. Clinical and Experimental Allergy. 2009; 39:962-965

Krimmer, D, Loseli, M, Hughes, J, Oliver, B, Moir, L, Hunt, N, Black, J, Burgess, J. CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy. 2009; 64:1074-82

Fukuyama, S, Nakano, T, Matsumoto, T, Oliver, B, Burgess, J, Moriwaki, A, Tanaka, K, Kubo, M, Hoshino, T, Tanaka, H, McKenzie, A, Matsumoto, K, Aizawa, H, Nakanishi, Y, Yoshimura, A, Black, J, Inoue, H. Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. American Journal of Respiratory and Critical Care Medicine. 2009; 179:992-998

Borger, P, Miglino, N, Baraket, M, Black, J, Tamm, M, Roth, M. Impaired translation of CCAAT/enhancer binding protein alpha mRNA in bronchial smooth muscle cells of asthmatic patients. The Journal of allergy and clinical immunology. 2009; 123:639-645

2008

Burgess, J, Lee, J, Ge, Q, Ramsay, E, Poniris, M, Parmentier, J, Roth, M, Johnson, P, Hunt, N, Black, J, Ammit, A. Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma. Journal of cellular physiology. 2008; 216:673-9

Hostettler, K, Roth, M, Burgess, J, Gencay, M, Gambazzi, F, Black, J, Tamm, M, Borger, P. Airway epithelium-derived transforming growth factor-beta is a regulator of fibroblast proliferation in both fibrotic and normal subjects. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2008; 38:1309-17

Oliver, B, Lim, S, Wark, P, Laza-Stanca, V, King, N, Black, J, Burgess, J, Roth, M, Johnston, S. Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax. 2008; 63:519-25

Moir, L, Burgess, J, Black, J. Transforming growth factor beta(1) increases fibronectin deposition through integrin receptor alpha(5)beta(1) on human airway smooth muscle. The Journal of Allergy and Clinical Immunology. 2008; 121:1034-1039.e4

Black, J, Burgess, J, Oliver, B, Moir, L. Altered properties of airway smooth muscle in asthma. In: Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology. United Kingdom: John Wiley & Sons Ltd 2008. p. 181-199.

2007

Matsumoto, H, Moir, L, Oliver, B, Burgess, J, Roth, M, Black, J, McParland, B. Comparison of gel contraction mediated by asthmatic and non-asthmatic airway smooth muscle cells. Thorax. 2007; 62:848-54

An, S, Bai, T, Bates, J, Black, J, Brown, R, Brusasco, V, Chitano, P, Deng, L, Dowell, M, Eidelman, D, Fabry, B, Fairbank, N, Ford, L, Fredberg, J, Gerthoffer, W, Gilbert, S, Gosens, R, Gunst, S, Halayko, A, Ingram, R, Irvin, C, James, A, Janssen, L, King, G, Knight, D, Lauzon, A, Lakser, O, Ludwig, M, Lutchen, K, Maksym, G, Martin, J, Mauad, T, McParland, B, Mijailovich, S, Mitchell, H, Mitchell, R, Mitzner, W, Murphy, T, Paré, P, Pellegrino, R, Sanderson, M, Schellenberg, R, Seow, C, Silveira, P, Smith, P, Solway, J, Stephens, N, Sterk, P, Stewart, A, Tang, D, Tepper, R, Tran, T, Wang, L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2007; 29:834-860

Ammit, A, Moir, L, Oliver, B, Hughes, J, Alkhouri, H, Ge, Q, Burgess, J, Black, J, Roth, M. The effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology. 2007; 292:L199-206

Borger, P, Matsumoto, H, Boustany, S, Gencay, M, Burgess, J, King, G, Black, J, Tamm, M, Roth, M. Disease-specific expression and regulation of CCAAT/enhancer-binding proteins in asthma and chronic obstructive pulmonary disease. The Journal of allergy and clinical immunology. 2007; 119:98-105

Roth, M, Black, J. Altered transcription factors in airway smooth muscle. In: New Frontiers in Smooth Muscle Biology and Physiology 2007. India: Transworld Research Network 2007. p. 431-456.

Roth, M, Black, J. The role of transcription factors in asthma: can we modify them for therapeutic purposes?. In: Asthma: Modern Therapeutic Targets. United Kingdom: Atlas Medical Publishing 2007. p. 33-48.

2006

Burgess, J, Oliver, B, Poniris, M, Ge, Q, Boustany, S, Cox, N, Moir, L, Johnson, P, Black, J. A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro. The Journal of allergy and clinical immunology. 2006; 118:649-57

Oliver, B, Black, J. Airway smooth muscle and asthma. Allergology International. 2006; 55:215-23

Borger, P, Tamm, M, Black, J, Roth, M. Asthma: Is it due to an abnormal airway smooth muscle cell?. American Journal of Respiratory and Critical Care Medicine. 2006; 174:367-372

Roth, M, Black, J. Transcription factors in asthma: Are transcription factors a new target for asthma therapy?. Current Drug Targets. 2006; 7:589-595

Zhong, J, Gencay, M, Bubendorf, L, Burgess, J, Parson, H, Robinson, B, Tamm, M, Black, J, Roth, M. ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells. Journal of cellular physiology. 2006; 207:540-52

Oliver, B, Johnston, S, Baraket, M, Burgess, J, King, N, Roth, M, Lim, S, Black, J. Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respiratory research. 2006; 7:71

Johnson, P, Burgess, J, Ge, Q, Poniris, M, Boustany, S, Twigg, S, Black, J. Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. American journal of respiratory and critical care medicine. 2006; 173:32-41

Burgess, J, Ge, Q, Poniris, M, Boustany, S, Twigg, S, Black, J, Johnson, P. Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. American journal of physiology. Lung cellular and molecular physiology. 2006; 290:L153-61

2005

Black, J, Ge, Q, Boustany, S, Johnson, P, Poniris, M, Glanville, A, Oliver, B, Moir, L, Burgess, J. In vitro studies of lymphangioleiomyomatosis. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2005; 26:569-76

Brightling, C, Ammit, A, Kaur, D, Black, J, Wardlaw, A, Hughes, J, Bradding, P. The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. American Journal of Respiratory and Critical Care Medicine. 2005; 171:1103-1108

Burgess, J, Blake, A, Boustany, S, Johnson, P, Armour, C, Black, J, Hunt, N, Hughes, J. CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle. The Journal of allergy and clinical immunology. 2005; 115:302-308

2004

Roth, M, Johnson, P, Borger, P, Bihl, M, Rüdiger, J, King, G, Ge, Q, Hostettler, K, Burgess, J, Black, J, Tamm, M. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. The New England journal of medicine. 2004; 351:560-74

McParland, B, Paré, P, Johnson, P, Armour, C, Black, J. Airway basement membrane perimeter in human airways is not a constant; potential implications for airway remodeling in asthma. Journal of applied physiology (Bethesda, Md. : 1985). 2004; 97:556-63

Hostettler, K, Roth, M, Burgess, J, Johnson, P, Glanville, A, Tamm, M, Black, J, Borger, P. Cyclosporine A mediates fibroproliferation through epithelial cells. Transplantation. 2004; 77:1886-93

Merrilees, M, Hankin, E, Black, J, Beaumont, B. Matrix proteoglycans and remodelling of interstitial lung tissue in lymphangioleiomyomatosis. The Journal of pathology. 2004; 203:653-60

Burgess, J, Ge, Q, Boustany, S, Black, J, Johnson, P. Increased sensitivity of asthmatic airway smooth muscle cells to prostaglandin E2 might be mediated by increased numbers of E-prostanoid receptors. The Journal of allergy and clinical immunology. 2004; 113:876-81

Johnson, P, Burgess, J, Underwood, P, Au, W, Poniris, M, Tamm, M, Ge, Q, Roth, M, Black, J. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. The Journal of allergy and clinical immunology. 2004; 113:690-6

Burgess, J, Carlin, S, Pack, R, Arndt, G, Au, W, Johnson, P, Black, J, Hunt, N. Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma?. The Journal of allergy and clinical immunology. 2004; 113:683-9

Azzola, A, Havryk, A, Chhajed, P, Hostettler, K, Black, J, Johnson, P, Roth, M, Glanville, A, Tamm, M. Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation. Transplantation. 2004; 77:275-80

2003

Black, J, Burgess, J, Johnson, P. Airway smooth muscle--its relationship to the extracellular matrix. Respiratory physiology & neurobiology. 2003; 137:339-46

Chambers, L, Black, J, Ge, Q, Carlin, S, Au, W, Poniris, M, Thompson, J, Johnson, P, Burgess, J. PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 2003; 285:L619-27

McClean, M, Matheson, M, McKay, K, Johnson, P, Rynell, A, Ammit, A, Black, J, Berend, N. Low lung volume alters contractile properties of airway smooth muscle in sheep. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2003; 22:50-6

Carlin, S, Roth, M, Black, J. Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 2003; 284:L1020-6

Burgess, J, Johnson, P, Ge, Q, Au, W, Poniris, M, McParland, B, King, G, Roth, M, Black, J. Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. American journal of respiratory and critical care medicine. 2003; 167:71-7

2002

Roth, M, Johnson, P, Rüdiger, J, King, G, Ge, Q, Burgess, J, Anderson, G, Tamm, M, Black, J. Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet. 2002; 360:1293-9

Black, J, Johnson, P. Factors controlling smooth muscle proliferation and airway remodelling. Current opinion in allergy and clinical immunology. 2002; 2:47-51

Borger, P, Black, J, Roth, M. Asthma and the CCAAT-enhancer binding proteins: A holistic view on airway inflammation and remodeling. Journal of Allergy and Clinical Immunology. 2002; 110:841-846

2001

Page, S, Ammit, A, Black, J, Armour, C. Human mast cell and airway smooth muscle cell interactions: implications for asthma. American journal of physiology. Lung cellular and molecular physiology. 2001; 281:L1313-23

Chambers, L, Black, J, Poronnik, P, Johnson, P. Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology. 2001; 281:L1369-78

Black, J, Roth, M, Lee, J, Carlin, S, Johnson, P. Mechanisms of airway remodeling. Airway smooth muscle. American journal of respiratory and critical care medicine. 2001; 164:S63-6

Johnson, P, Roth, M, Tamm, M, Hughes, M, Ge, Q, King, G, Burgess, J, Black, J. Airway smooth muscle cell proliferation is increased in asthma. American journal of respiratory and critical care medicine. 2001; 164:474-7

Lee, J, Johnson, P, Roth, M, Hunt, N, Black, J. ERK activation and mitogenesis in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 2001; 280:L1019-29

Black, J, Johnson, P, Armour, C. Factors controlling transduction signaling and proliferation of airway smooth muscle. Current allergy and asthma reports. 2001; 1:116-21

Tamm, M, Roth, M, Malouf, M, Chhajed, P, Johnson, P, Black, J, Glanville, A. Primary fibroblast cell cultures from transbronchial biopsies of lung transplant recipients. Transplantation. 2001; 71:337-9

Black, J, Armour, C, Tamm, M, Roth, M, Johnson, P. Airway Wall remodelling-the role of the smooth muscle. Clinical & Experimental Allergy Reviews. 2001; 280:L1019-L1029

2000

Carlin, S, Poronnik, P, Cook, D, Johnson, P, Black, J, Carpenter, L, Biden, T. An Antisense of Protein Kinase C- Inhibits Proliferation of Human Airway Smooth Muscle Cells. American Journal of Respiratory Cell and Molecular Biology. 2000; 23:555-559

Carlin, S, Poronnik, P, Cook, D, Carpenter, L, Biden, T, Johnson, P, Black, J. An antisense of protein kinase C-? inhibits proliferation of human airway smooth muscle cells. American Journal of Repiratory Cell and Molecular Biology. 2000; 23:555-559

McParland, B, Johnson, P, Armour, C, Black, J. An epithelial-derived factor inhibits contraction in canine perfused bronchial segments. European Journal of Pharmacology. 2000; 402:151-159

McKay, K, Johnson, P, Black, J, Armour, C. Parasympathetic neurotransmission in rabbit isolatedbronchus is modulated at prejunctional sites via endothelinB receptor stimulation. Respirology. 2000; 5:343-353

Ammit, A, Armour, C, Black, J. Smooth-muscle myosin light-chain kinase content is increased in human sensitized airways. American Journal of Respiratory and Critical Care Medicine. 2000; 161:257-263

Johnson, P, Black, J, Carlin, S, Ge, Q, Underwood, A. The production of extracellular matrix proteins by human passively sensitized airway smooth muscle cells in culture. American Journal of Respiratory and Critical Care Medicine. 2000; 162:2145-2151

Black, J, Johnson, P. What Determines Asthma Phenotype? Is it the Interaction between Allergy and the Smooth Muscle. American Journal of Respiratory and Critical Care Medicine. 2000; 161:S207-S210