Professor Georges Emile Raymond Grau

E:	georges.grau@bosch.org.au
T:	+61 2 9036 3260
F:	+61 2 9036 3177
Personal Homepage

K25 - Medical Foundation Building
The University of Sydney
NSW 2006 Australia

Biographical details
Research interests
Competitive grants
Publications

Biographical details

2006 - present: Professor, Chair of Vascular Immunology, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of Sydney

1999 - 2006: Professeur des Universites (Physiologie, section 40), Universite de la Mediterranee

1998 - 1999: Research Associate, CNRS, Prof. D. Raoult, Marseille

1997 - 1998: Invited Professor, Department of Pathology, University of Regensburg

1995 - 1997: Chef de Clinique Scientifique, University of Geneva

1992: Privat - Docent (Agregation de l'Enseignement Superieur), Faculty of Medicine, University of Geneva

1991 - 1995: Maitre de'Enseignement et de Recherche at the WHO Centre and at the Department of Pathology, University of Geneva

1989 - 1991: Charge de Recherche, Departement de Pathologie, University of Geneva

1984 - 1988: Assistant en Medecine Fondamentale, Department of Pathology, University of Geneva

1984: M.D. Thesis, University of Geneva

1983: Candidate-Specialist in Internal Medicine, Universite de Liege

1982 - 1995: Research Associate, World Health Organisation, Immunology Research and Training Centre, Prof. P.H. Lambert, University of Geneva, Switzerland

1981 - 1982: Post-Doctoral Fellow, Institut de Pathologie Cellulaire, Prof. M. Bessis, Hopital du Kremlin-Bicetre, Paris, France

1979 - 1983: Resident, Department of Internal Medicine, Prof. H. van Cauwenberghe, Hopital Universitaire de Baviere, Liege

1972 - 1979: Doctor of Medicine (with High Distinction), University of Liege

Research interests

Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.
Additional keywords: endothelium; cytokines; platelets; microparticles; brain diseases; cerebral malaria; sepsis; septic shock

Current national competitive grants

2009

Pathophysiological alterations of brain microvascular endothelial cells in cerebral malaria

NHMRC Project Grants

$344,250 over 3 years

Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis

NHMRC Project Grants

$438,000 over 3 years

2008

Dysregulation of cytokine networks: a key determinant of the pathogenesis of cerebral malaria

NHMRC Project Grant

$461,625 over 3 years

Publications

2010: Mitchell, A, Pradel, L, Chasson, L, Van Rooijen, N, Grau, G, Hunt, N, Chimini, G. Technical Advance: Autofluorescence as a tool for myeloid cell analysis. Journal of leukocyte biology. 2010; :; Combes, V, El-Assaad, F, Faille, D, Jambou, R, Hunt, N, Grau, G. Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis. Progress in neurobiology. 2010; 91:140-51; Hunt, N, Grau, G, Engwerda, C, Barnum, S, van der Heyde, H, Hansen, D, Schofield, L, Golenser, J. Murine cerebral malaria: the whole story. Trends in parasitology. 2010. p. 272-4.; Bridges, D, Bunn, J, van Mourik, J, Grau, G, Preston, R, Molyneux, M, Combes, V, O'Donnell, J, de Laat, B, Craig, A. Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings. Blood. 2010; 115:1472-4
2009: Zhang, W, Wu, L, Liu, H, Ye, L, Xin, Y, Grau, G, Lou, J. Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation. Microvascular Research. 2009; 78:379-385; Gouado, I, Pankoui M, J, Fotso K, H, Zambou, O, Nguélé, S, Combes, V, Grau, G, Amvam Z, P. Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. The Pediatric Infectious Disease Journal. 2009; 28:1081-1084; Bechah, Y, Capo, C, Grau, G, Raoult, D, Mege, J. Rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through alphabeta integrin engagement. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2009; 15 Suppl 2:249-50; Faille, D, El-Assaad, F, Alessi, M, Fusai, T, Combes, V, Grau, G. Platelet-endothelial cell interactions in cerebral malaria: The end of a cordial understanding. Thrombosis and haemostasis. 2009; 102:1093-1102; Faille, D, Combes, V, Mitchell, A, Fontaine, A, Juhan-Vague, I, Alessi, M, Chimini, G, Fusa��, T, Grau, G. Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009; 23:3449-58; Bebawy, M, Combes, V, Lee, E, Jaiswal, R, Gong, J, Bonhoure, A, Grau, G. Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2009; 23:1643-9; Jambou, R, El-Assaad, F, Combes, V, Grau, G. Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. The International Journal of Biochemistry & Cell Biology. 2009; 41:1467-1470; Larkin, D, de Laat, B, Jenkins, P, Bunn, J, Craig, A, Terraube, V, Preston, R, Donkor, C, Grau, G, van Mourik, J, O'Donnell, J. Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathogens. 2009; 5:e1000349; Bruzzone, R, Dubois-Dalcq, M, Grau, G, Griffin, D, Kristensson, K. Infectious diseases of the nervous system and their impact in developing countries. PLoS Pathogens. 2009; 5:e1000199
2008: Ramaswamy, Y, Wu, C, Van Hummel, A, Combes, V, Grau, G, Zreiqat, H. The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials. 2008; 29:4392-402; von Zur Muhlen, C, Sibson, N, Peter, K, Campbell, S, Wilainam, P, Grau, G, Bode, C, Choudhury, R, Anthony, D. A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. The Journal of clinical investigation. 2008; 118:1198-207; Penet, M, Abou-Hamdan, M, Coltel, N, Cornille, E, Grau, G, de Reggi, M, Gharib, B. Protection against cerebral malaria by the low-molecular-weight thiol pantethine. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105:1321-1326; Wu, L, Zhang, W, Niu, J, Ye, L, Yang, Z, Grau, G, Lou, J. Phenotypic and functional differences between human liver cancer endothelial cells and liver sinusoidal endothelial cells. Journal of vascular research. 2008; 45:78-86
2007: Bechah, Y, Capo, C, Grau, G, Raoult, D, Mege, J. A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. Microbes and infection / Institut Pasteur. 2007; 9:898-906; Penet, M, Kober, F, Confort-Gouny, S, Le Fur, Y, Dalmasso, C, Coltel, N, Liprandi, A, Gulian, J, Grau, G, Cozzone, P, Viola, A. Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA. The Journal of biological chemistry. 2007; 282:14505-14514; Combes, V, Lou, J, Grau, G. The Endothelium in Cerebral Malaria: Both a Target Cell and a Major Player. In: Endothelial Biomedicine. United Kingdom: Cambridge University Press 2007. p. 1303-1310.; Rose, S, Quesniaux, V, Schofield, L, Beutler, B, Ryffel, B, Boissay, V, Grau, G, Togbe, D, Charron, S, Schnyder, B. Murine cerebral malaria development is independent of Toll-like receptor signaling. AMERICAN JOURNAL OF PATHOLOGY. 2007; 170:1640-1648; Delahaye, N, Coltel, N, Puthier, D, Barbier, M, Benech, P, Joly, F, Iraqi, F, Grau, G, Nguyen, C, Rihet, P. Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice. BMC genomics. 2007; 8:452; Zhang, W, Lou, J, Grau, G, Yang, Z, Zhu, G, Ye, L, Niu, J, Wu, L. The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. EUROPEAN JOURNAL OF CANCER PREVENTION. 2007; 16:517-527
2006: Golenser, J, Waknine, J, Krugliak, M, Hunt, N, Grau, G. Current perspectives on the mechanism of action of artemisinins. International journal for parasitology. 2006; 36:1427-41; van der Heyde, H, Nolan, J, Combes, V, Gramaglia, I, Grau, G. A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends in parasitology. 2006; 22:503-8; Coltel, N, Combes, V, Wassmer, S, Chimini, G, Grau, G. Cell vesiculation and immunopathology: implications in cerebral malaria. Microbes and infection / Institut Pasteur. 2006; 8:2305-16; Combes, V, Coltel, N, Faille, D, Wassmer, S, Grau, G. Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. International journal for parasitology. 2006; 36:541-6; Schofield, L, Grau, G. Oversimplification of the role of immunological processes in the pathogenesis of malaria - Author reply. Nature Reviews Immunology. 2006; 6:0; Hunt, N, Grau, G. Blood-brain barrier in parasitic disease. International journal for parasitology. 2006; 36:503-4; Wassmer, S, Cianciolo, G, Combes, V, Grau, G. LMP-420, a new therapeutic approach for cerebral malaria?. M S-Medecine Sciences. 2006; 22:343-345; Wassmer, S, de Souza, J, Frère, C, Candal, F, Juhan-Vague, I, Grau, G. TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. Journal of immunology (Baltimore, Md. : 1950). 2006; 176:1180-4; Zhang, W, Ye, L, Wu, L, Xin, Y, Gu, F, Niu, J, Yang, Z, Zhu, G, Grau, G, Lou, J. Morphologic, Phenotypic and Functional Characteristics of Endothelial Cells Derived from Human Hepatic Cavernous Hemangioma. Journal of vascular research. 2006; 43:522-32
2005: Wassmer, S, Cianciolo, G, Combes, V, Grau, G. Inhibition of endothelial activation: a new way to treat cerebral malaria?. PLoS Medicine. 2005; 2:e245; Schofield, L, Grau, G. Immunological processes in malaria pathogenesis. Nature Reviews. Immunology. 2005; 5:722-735; Penet, M, Viola, A, Confort-Gouny, S, Le Fur, Y, Duhamel, G, Kober, F, Ibarrola, D, Izquierdo, M, Coltel, N, Gharib, B, Grau, G, Cozzone, P. Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema. The Journal of Neuroscience. 2005; 25:7352-7358; Combes, V, De Souza, J, Rénia, L, Hunt, N, Grau, G. Cerebral malaria: Which parasite? Which model?. Drug Discovery Today: Disease Models. 2005; 2:141-147; Combes, V, Coltel, N, Alibert, M, van Eck, M, Raymond, C, Juhan-Vague, I, Grau, G, Chimini, G. ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology. American Journal of Pathology. 2005; 166:295-302; Grau, G, Chimini, G. Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. Journal de la Société de Biologie. 2005; 199:199-206
2003: Hunt, N, Grau, G. Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends in immunology. 2003; 24:491-9; Wassmer, S, Combes, V, Grau, G. Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion. Annals of the New York Academy of Sciences. 2003; 992:30-8; Grau, G, Mackenzie, C, Carr, R, Redard, M, Pizzolato, G, Allasia, C, Cataldo, C, Taylor, T, Molyneux, M. Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. The Journal of infectious diseases. 2003; 187:461-6; Wassmer, S, Coltel, N, Combes, V, Grau, G. [Pathogenesis of cerebral malaria: facts and hypotheses]. Médecine tropicale : revue du Corps de santé colonial. 2003; 63:254-7
2002: Stoelcker, B, Hehlgans, T, Weigl, K, Bluethmann, H, Grau, G, Männel, D. Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Infection and immunity. 2002; 70:5857-9; Hamacher, J, Lucas, R, Lijnen, H, Buschke, S, Dunant, Y, Wendel, A, Grau, G, Suter, P, Ricou, B. Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome. American journal of respiratory and critical care medicine. 2002; 166:651-6
2001: Lou, J, Lucas, R, Grau, G. Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clinical microbiology reviews. 2001; 14:810-20, table of contents; Harbarth, S, Holeckova, K, Froidevaux, C, Pittet, D, Ricou, B, Grau, G, Vadas, L, Pugin, J, , G. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. American journal of respiratory and critical care medicine. 2001; 164:396-402; Lucas, R, Montesano, R, Pepper, M, Hafner, M, Sablon, E, Dunant, Y, Grau, G, De Baetselier, P, Männel, D, Fransen, L. Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule. International journal of cancer. Journal international du cancer. 2001; 91:543-9

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