Associate Professor Vladimir Balcar

• Research interests
• Publications

Research interests

Publications

2008

Getts, D, Balcar, V, Matsumoto, I, M��ller, M, King, N. Viruses and the immune system: their roles in seizure cascade development. Journal of neurochemistry. 2008; 104:1167-76

2007

Bröer, S, Bröer, A, Hansen, J, Bubb, W, Balcar, V, Nasrallah, F, Garner, B, Rae, C. Alanine metabolism, transport, and cycling in the brain. Journal of neurochemistry. 2007; 102:1758-1770

Nasrallah, F, Griffin, J, Balcar, V, Rae, C. Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007; 27:1510-20

Moussa, C, Rae, C, Bubb, W, Griffin, J, Deters, N, Balcar, V. Inhibitors of glutamate transport modulate distinct patterns in brain metabolism. Journal of neuroscience research. 2007; 85:342-50

2006

Rae, C, Moussa, C, Griffin, J, Parekh, S, Bubb, W, Hunt, N, Balcar, V. A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006; 26:1005-17

Balcar, V, Nanitsos, E. Autoradiography of H-3 aspartate and glutamate transport in chizophrenia. Neuropsychopharmacology. 2006; 31:685-686

Kaiser, M, Mareš, V, Sťastný, F, Bubeníková, V, Lisá, V, Suchomel, P, Balcar, V. The influence of interleukin-1beta on gamma-glutamyl transpepidase activity in rat hippocampus. Physiological research / Academia Scientiarum Bohemoslovaca. 2006; 55:461-5

Kaiser, M, Mares, V, Stastny, F, Bubenikova-Valesova, V, Lisa, V, Suchomel, P, Balcar, V. The influence of interleukin-1 beta on gamma-glutamyl transpeptidase activity in rat hippocampus. Physiological Research. 2006; 55:461-465

Bubenikova-Valesova, V, Balcar, V, Tejkalova, H, Langmeier, M, St'astny, F. Neonatal administration of N-acetyl-L-aspartyl-L-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats. Neurochemistry International. 2006; 48:515-522

2005

Nanitsos, E, Nguyen, K, St'astný, F, Balcar, V. Glutamatergic hypothesis of schizophrenia: involvement of Na(+)/K(+)-dependent glutamate transport. Journal of biomedical science. 2005; 12:975-84

Parekh, S, Moussa, C, Balcar, V, Hunt, N, Bubb, W, Rae, C. Quinolinic acid, kynurenic acid and dserine stimulate brain metabolism. Journal of Neurochemistry. 2005; 94:58-58

Stastny, F, Tejkalova, H, Skuba, I, Balcar, V, Kaiser, M, Stastny, F. Quinolinic acid, NMDA receptor and schizophrenia: Testing an integrative theory. In: Amino Acid Signalling 04. Trivandrum, India: Research Signpost 2005. p. 67-83.

Rae, C, Moussa, C, Griffin, J, Bubb, W, Wallis, T, Balcar, V. Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic study. Journal of neurochemistry. 2005; 92:405-16

2004

Nanitsos, E, Acosta, G, Saihara, Y, Stanton, D, Liao, L, Shin, J, Rae, C, Balcar, V. Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro. Clinical and experimental pharmacology & physiology. 2004; 31:762-9

Takarada, T, Hinoi, E, Balcar, V, Taniura, H, Yoneda, Y. Possible expression of functional glutamate transporters in the rat testis. The Journal of endocrinology. 2004; 181:233-44

Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004; 18:499-510

Wallis, T, Bubb, W, McQuillan, J, Balcar, V, Rae, C. For want of a nail. ramifications of a single gene deletion, dystrophin, in the brain of the mouse. Frontiers in bioscience : a journal and virtual library. 2004; 9:74-84

St'astný, F, Lisá, V, Mares, V, Lisá, V, Balcar, V, Santamaría, A. Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels. Redox report : communications in free radical research. 2004; 9:229-33

Balcar, V, Stastny, F, Tejkalova, H, Skuba, I, Palenicek, T, Pliss, L, Mares, V, Kristofikova, Z, Kaiser, M, Bubenikova, V, Balcar, V. Interactions of Dopamine D1/D2 Receptor with Glutamate Receptor of NMDA type: from Molecules to Animal Models of Schizophrenia (in Czech). Psychiatrie (Prague). 2004; 8:26-35

Balcar, V, Stastny, F, Tejkalova, H, Skuba, I, Palenicek, T, Pliss, L, Mares, V, Kristofikova, Z, Kaiser, M, Bubenikova, V, Balcar, V. Interactions of Dopamine D1/D2 Receptor with Glutamate Receptor of NMDA type: from Molecules to Animal Models of Schizophrenia (in Czech). Psychiatrie (Prague). 2004; 8:26-35

2003

Rae, C, Hare, N, Bubb, W, McEwan, S, Broer, A, McQuillan, J, Balcar, V, Conigrave, A, Broer, S. Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. Journal Of Neurochemistry. 2003; 85:503-514

Stasny, F, Lisy, V, Mares, V, Jezova, D, Santamaria, A, Balcar, V. Functional glutamate resceptors are expressed in rat brain capillary barrier. Psychiatrie. 2003; 7 (2):127-128

St Asny, F, Tejkalova, H, Hoschel, C, Balcar, V. Viral infection, glutamatergic deficit and behavioural changes in animal model of schizophrenia. Psychiatrie. 2003; 7:128-130

Pliss, L, Balcar, V, Bubenikova, V, Pokorny, J, Fitzgibbon, T, St'astny, F. Morphology and ultrastructure of rat hippocampal formation after I.C.V administration of N-ACETYL-l-ASPARTYL-l-GLUTAMATE. Neuroscience. 2003; 122(2003):93-101

Stanton, D, Liao, L, Moussa, C, Bubb, W, Rae, C, Balcar, V. Can inhibition of glutamate transport contribute to the actions of neuroleptics?. Psychiatrie. 2003; 7:6-11

Bubenikova, V, Balcar, V, Tejkalova, H, Horacek, J, St'astny, F. Significance of neonatal excitotoxic brain lesions in a neurodevelopmental model of schizophrenia. Psychiatrie. 2003; ; 2003

Rae, C, McQuillan, J, Parekh, S, Bubb, W, Weiser, S, Balcar, V, Hansen, A, Ball, H, Hunt, N. Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. Faseb Journal. 2003; 18:499-510

Wallis, T, Bubb, W, McQuillan, J, Balcar, V, Rae, C. For want of a nail. Ramifications of a single gene deletion, dystrophin, in the brain of the mouse. Frontiers In Bioscience. 2003; 9:74-84

Jeffrey, P, Balcar, V, Tolhurst, O, Weinberger, R, Meany, J. Avian purkinje neuronal cultures: extrinsic control of morphology by cell type and glutamate. In: Methods in Cell Biology: Volume 71: Neurons: Methods and applications for the Cell Biologist. Amsterdam: Academic Press (Elsevier) 2003. p. 91-109.

2002

Hinoi, E, Fujimori, S, Balcar, V, Kubo, K, Ogita, K, Yoneda, Y. Constitutive expression of heterologous N-Methyl-D-aspartate receptor subunits in rat adrenal medulla. Journal Of Neuroscience Research. 2002; 68:36-45

Takamoto, A, Quiggin, L, Lieb, I, Shave, E, Balcar, V, Yoneda, Y. Differences between D- and L-aspartate binding to the Na+-dependent binding sites on glutamate transporters in frozen sections of rat brain. Life Sciences. 2002; 70:991-1001

Moussa, C, Mitrovic, A, Vandenberg, R, Provis, T, Rae, C, Bubb, W, Balcar, V. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1S,2R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochemical Research. 2002; 27:27-35

Moussa, C, Mitrovic, A, Vandenberg, R, Provis, T, Rae, C, Bubb, W, Balcar, V. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1S,2R)-2-(Carboxycyclopropyl) glycine (L-CCF III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy*. Neurochemical Research. 2002; 27 nos1/2:27-35

Balcar, V. Molecular pharmacology of the Na+-dependent transport of acidic amino acids in the mammalian central nervous system. Biological & Pharmaceutical Bulletin. 2002; 25 (3):291-301

Pliss, L, Jezova, D, Mares, V, Balcar, V, Stastny, F. N-Acetyl-L-aspartyl-L-glutamate changes functional & structural properties of rat blood-brain barrier. Neuroscience Letters. 2002; 317:85-88

Hinoi, E, Balcar, V, Kuramoto, N, Nakamichi, N, Yoneda, Y. Nuclear transcription factors in the hippocampus. Progress In Neurobiology. 2002; 68:145-165

Hirai, T, Kuramoto, N, Maruyama, H, Balcar, V, Nakamura, Y, Yoneda, Y. Petentiation of Nuclear Activator Protein-1 DNA binding following brief exposure to N-Methly-D-Aspartate in immature cultured rat hippocampal neurons. Journal Of Neuroscience Research. 2002; 67:523-532

2001

Balcar, V, Takamoto, A, Yonida, Y. Neurochemistry of L-glutamiate transport in the CNS: A review of the thirty years of progress. Collection of Czechoslovak Chemical Communications. 2001; 358:1941-1945

Shave, E, Pliss, L, Lawrence, M, Fitzgibbon, T, Stastny, F, Balcar, V. Regional distribution and pharmacological characteristics of [3H]N-acetyle-aspartyl-glutamate (NAAG) binding sites in rat brain. Neurochemistry International. 2001; 25 (3):203-211

2000

Shave, E, Pliss, L, Lawrence, M, FitzGibbon, T, Stastny, F, Balcar, V. Regional distribution & pharmacological characteristics of [3H]n-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain. Neurochemistry International. 2000; 38 (1):53-62

Rae, C, Lawrence, M, Dias, L, Provis, T, Bubb, W, Balcar, V. Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slices. Brain Research Bulletin. 2000; 53:373-381

Duke, R, Chebib, M, Balcar, V, Allan, R, Mewett, K, Johnston, G. (+) and (-)-cis-2-Aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant p1 and p2 GABAC receptors. Journal of Neurochemistry. 2000; 75, No.6:2602-2610

Duke, R, Collins, M, Balcar, V, Allan, R, Mewett, K, Johnston, G. (+) and (-)-cis-2-Aminomethylcyclopropanecarboxylic Acids show opposite Pharmacology at recombinant p1 and p2 GABAc receptors. Journal of Neurochemistry. 2000; 75 (6):2602-2610

Berry, D, Balcar, V, Barden, J, Keogh, A, dos Remedios, C. Determination of P2X1 (alpha)-sarcoglycan (adhalin) expression levels in failing human dilated cardiomyopathic left ventricles. Electrophoresis. 2000; 21 (170:3857-3862

Pliss, L, FitzGibbon, T, Balcar, V, St'astny, F. Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands. NeuroReport. 2000; 11 (16):3651-3654

Lieb, I, Collins, M, Cooper, B, Dias, L, Balcar, V. Quantitative autoradiography of Na+ -dependent [3H]L-aspartate binding to L-glutamate transporters in rat brain: structure-activity studies using L-trans-pyrrolidine-2, 4-dicarboxylate (L-t-PDC) and 2-(carboxycyclopropyl)-glycine (CCG). Neurochemistry International. 2000; 36 (4-5):319-327