Associate Professor Frank Lovicu

E:  frank.lovicu@bosch.org.au T:  +61 2 9351 5170 F:  +61 2 9351 2813  Personal Homepage F13 - Anderson Stuart Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2008

Wang, Q, Stump, R, McAvoy, J, Lovicu, F. MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Experimental Eye Research. 2008; 0:0

Chen, Y, Stump, R, Lovicu, F, Shimono, A, McAvoy, J. Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental biology. 2008; :

Chong, C, Stump, R, Lovicu, F, McAvoy, J. TGFbeta promotes Wnt expression during cataract development. Experimental eye research. 2008; :

2007

Markus, M, Goy, C, Adams, D, Lovicu, F, Morris, B. Renin Enhancer Is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension. 2007; 50:933-8

Jamieson, R, Farrar, N, Stewart, K, Perveen, R, Mihelec, M, Carette, M, Grigg, J, McAvoy, J, Lovicu, F, Tam, P, Scambler, P, Lloyd, I, Donnai, D, Black, G. Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human mutation. 2007; 28:968-977

Iyengar, L, Wang, Q, Rasko, J, McAvoy, J, Lovicu, F. Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation; research in biological diversity. 2007; 75:662-8

Lovicu, F, Ziman, M, Thompson, J. Pax7 and superior collicular polarity: insights from Pax6 (Sey) mutant mice. EXPERIMENTAL BRAIN RESEARCH. 2007; 178:316-325

Sohaskey, M, Lovicu, F, McAvoy, J, Little, M, Kolle, G, Wilkinson, L, Pennisi, D, Gillinder, K, Piper, M. Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. DEVELOPMENTAL DYNAMICS. 2007; 236:502-511

2006

Lovicu, F. Cell signaling in lens development. Seminars in cell & developmental biology. 2006; 17:675

Chen, Y, Stump, R, Lovicu, F, McAvoy, J. A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?. Seminars in cell & developmental biology. 2006; 17:712-25

Boros, J, Newitt, P, Wang, Q, McAvoy, J, Lovicu, F. Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation. Seminars in cell & developmental biology. 2006; 17:741-52

Adams, D, Head, G, Markus, M, Lovicu, F, van der Weyden, L, Köntgen, F, Arends, M, Thiru, S, Mayorov, D, Morris, B. Renin enhancer is critical for control of renin gene expression and cardiovascular function. The Journal of biological chemistry. 2006; 281:31753-61

Symonds, J, Lovicu, F, Chamberlain, C. Differing effects of dexamethasone and diclofenac on posterior capsule opacification-like changes in a rat lens explant model. Experimental eye research. 2006; 83:771-82

Stump, R, Lovicu, F, Ang, S, Pandey, S, McAvoy, J. Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. The Journal of pathology. 2006; 210:249-57

Iyengar, L, Patkunanathan, B, Lynch, O, McAvoy, J, Rasko, J, Lovicu, F. Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Experimental eye research. 2006; 83:667-678

Symonds, J, Lovicu, F, Chamberlain, C. Posterior capsule opacification-like changes in rat lens explants cultured with TGFbeta and FGF: effects of cell coverage and regional differences. Experimental eye research. 2006; 82:693-9

2005

Lovicu, F, McAvoy, J. Growth factor regulation of lens development. Developmental biology. 2005; 280:1-14

de Iongh, R, Wederell, E, Lovicu, F, McAvoy, J. Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells, tissues, organs. 2005; 179:43-55

2004

Lovicu, F, Steven, P, Saika, S, McAvoy, J. Aberrant lens fiber differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6. Investigative ophthalmology & visual science. 2004; 45:1946-53

Thompson, J, Lovicu, F, Ziman, M. The role of Pax7 in determining the cytoarchitecture of the superior colliculus. Development, growth & differentiation. 2004; 46:213-8

Ang, S, Stump, R, Lovicu, F, McAvoy, J. Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene expression patterns : GEP. 2004; 4:289-95

Lovicu, F, Ang, S, Chorazyczewska, M, McAvoy, J. Deregulation of Lens Epithelial Cell Proliferation and Differentiation during the Development of TGF?-induced Anterior Subcapsular CataractAC -. Developmental Neuroscience. 2004; 26:442-451

Lovicu, F, Robinson, M. The Lens: Historical and Comparative Perspectives. In: Development of the Ocular Lens. New York: Cambridge University Press 2004. p. 3-26.

Chen, Y, Stump, R, Lovicu, F, McAvoy, J. Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development. The International journal of developmental biology. 2004; 48:867-77

Lovicu, F, Robinson, M. Development of the Ocular Lens. New York: Cambridge University Press, 2004.

2003

Yager, M, Hughes, J, Lovicu, F, Gunning, P, Weinberger, R, O'Neill, G. Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma. British journal of cancer. 2003; 89:860-3

Stump, R, Ang, S, Chen, Y, von Bahr, T, Lovicu, F, Pinson, K, De Iongh, R, Yamaguchi, T, Sassoon, D, McAvoy, J. A role for Wnt/Beta-catenin signaling in lens epithelial differentiation. Developmental Biology. 2003; 259:48-61

2002

Bradbury, R, Cropley, J, Kifor, O, Lovicu, F, de Iongh, R, Kable, E, Brown, E, Seely, E, Peat, B, Conigrave, A. Localization of the extracellular Ca(2+)-sensing receptor in the human placenta. Placenta. 2002; 23:192-200

2001

Lovicu, F, McAvoy, J. FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/1) signalling. Development. 2001; 27, No. 3:309-312

Zhao, S, Hung, F, Colvin, J, White, A, Dai, W, Lovicu, F, Ornitz, D, Overbeek, P. Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development. 2001; 8:259-265

De Iongh, R, Lovicu, F, Overbeek, P, Schneider, M, Joya, J, Hardeman, E, McAvoy, J. Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development. 2001; 127:297-303

2000

Lovicu, F, McAvoy, J. Growth factor signaling in lens cell proliferation & differentiation. XIV International congress of eye research. 2000; Sant Fe USA; 2000

Adams, D, Lovicu, F, Morris, B, Kovacic, A, Copeland, N, Gilbert, D, Jenkins, N, Ioannou, P, Van Der Weyden, L. Chromosome localisation and characterisation of the mouse and human zinc finger protein 265 gene. Cytogenetics and Cell Genetics. 2000; 88:68-73

Lovicu, F, Kolle, G, Yamada, T, Little, M, McAvoy, J. Expression of Crim1 during murine ocular development. Mechanisms of Development. 2000; 94:261-265

McAvoy, J, Chamberlain, C, De Iongh, R, Hales, A, Lovicu, F. Growth factors in lens development and cataract: key roles for fibroblast growth factor and TGF-b. Clinical and Experimental Ophthalmology. 2000; 28:133-139

McAvoy, J, Chamberlain, C, De Iongh, R, Hales, A, Lovicu, F. Peter Bishop Lecture: Growth factors in lens development & cataract: key roles for fibroblast growth factor and TGF-B. Clinical & Experimental Ophthalmology. 2000; 28 (3):133-139

McAvoy, J, Overbeek, P, Lovicu, F. Subcapsular cataract induced by TGFB involves an epithelial-mesenchymal transition & aberrant fibre differentiation. XIV international congress of eye research. 2000; Santa Fe New Mexico, USA; 2000