Associate Professor Brett Hambly
D06 - Blackburn Building
The University of Sydney NSW 2006 Australia |
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1980-81 Intern and Resident Medical Officer, Royal Prince Alfred Hospital, Sydney
1982-84 Relief Staff - Medical, Royal Prince Alfred Hospital, Sydney
1982-84 Life Insurance Medical Research Fund of Australia & New Zealand Research Scholar (Candidate for Ph.D.), Department of Anatomy, University of Sydney
1984-86 Temporary Lecturer, Department of Anatomy, University of Sydney
1987-88 NHMRC CJ Martin Post-doctoral Research Fellow,
Department of Biochemistry and Biophysics, University of California, San Francisco
1989-90 NHMRC CJ Martin Post-doctoral Research Fellow, Dept of Anatomy, Univ Sydney
1991 NHMRC Senior Research Officer, Department of Anatomy, University of Sydney
1992-93 Lecturer, Department of Pathology, University of Sydney
1994-02 Senior Lecturer, Department of Pathology, University of Sydney
2003- Associate Professor, School Medical Science - Pathology Discipline, Univ Sydney
2003- Adjunct Assoc Professor, Biology (Molec Biophysics), Florida State Univ, Tallahassee
1982-84 Relief Staff - Medical, Royal Prince Alfred Hospital, Sydney
1982-84 Life Insurance Medical Research Fund of Australia & New Zealand Research Scholar (Candidate for Ph.D.), Department of Anatomy, University of Sydney
1984-86 Temporary Lecturer, Department of Anatomy, University of Sydney
1987-88 NHMRC CJ Martin Post-doctoral Research Fellow,
Department of Biochemistry and Biophysics, University of California, San Francisco
1989-90 NHMRC CJ Martin Post-doctoral Research Fellow, Dept of Anatomy, Univ Sydney
1991 NHMRC Senior Research Officer, Department of Anatomy, University of Sydney
1992-93 Lecturer, Department of Pathology, University of Sydney
1994-02 Senior Lecturer, Department of Pathology, University of Sydney
2003- Associate Professor, School Medical Science - Pathology Discipline, Univ Sydney
2003- Adjunct Assoc Professor, Biology (Molec Biophysics), Florida State Univ, Tallahassee
My research focuses on cardiovascular disease, in particular familial hypertrophic cardiomyopathy and atherosclerosis.
Current national competitive grants
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2009 |
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A temporal profile of signalling via phosphorylation during myocardial ischemia / reperfusion injury |
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| NHMRC Project Grants | $355,050 over 3 years |
2008
- Wu, H, Craft, M, Wang, P, Wyburn, K, Chen, G, Ma, J, Hambly, B, Chadban, S. IL-18 Contributes to Renal Damage after Ischemia-Reperfusion. Journal of the American Society of Nephrology : JASN. 2008; 19:2331-41
- Ko, H, Hambly, B, Eris, J, Levidiotis, V, Wyburn, K, Wu, H, Chadban, S, Yin, J. Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. Transplant immunology. 2008; 20:99-105
- Stefani, M, Tsubakihara, M, Allen, P, Macdonald, P, dos Remedios, C. Actin and its binding proteins in heart failure. In: Actin-binding proteins and disease. United Kingdom: Springer 2008. p. 318-334.
- Hambly, B, Oakley, C, Fajer, P. Protein comparative sequence analysis and computer modeling. Methods in molecular medicine. 2008; 141:245-56
- Hambly, B, Oakley, C, Fajer, P. Protein Comparative Sequence Analysis and Computer Modeling. In: Clinical Bioinformatics. New Jersey, USA: Humana Press Inc. 2008. p. 245-256.
- Tavakoli, N, Hambly, B, Sullivan, D, Bao, S. Forkhead box protein 3: Essential immune regulatory role. The international journal of biochemistry & cell biology. 2008; 40:2369-73
2007
- Bao, S, Hambly, B, Harris, A, Tavakoli, N. Interferon-gamma contributes to neointimal proliferation following arterial angioplasty in a mouse model. ATHEROSCLEROSIS SUPPLEMENTS. 2007; 8:65-66
- Harris, A, Bao, S, Hambly, B, Prabhu, K. Absence of toll-like receptor 4 increases macrophage population and collagen content in an endothelial denudation mouse model of neointimal proliferation. ATHEROSCLEROSIS SUPPLEMENTS. 2007; 8:229-229
- Fajer, P, Kekic, M, Hambly, B, Hwang, J, Oakley, C, Brown, L. F-actin binding to the N-terminal region of cardiac myosin binding protein-C. BIOPHYSICAL JOURNAL. 2007; Supp:489A-489A
- Fang, Y, Bao, S, Hambly, B, Gong, S, Xu, Y. Impaired cutaneous wound healing in granulocyte/macrophage colony-stimulating factor knockout mice. BRITISH JOURNAL OF DERMATOLOGY. 2007; 157:458-465
- Oakley, C, Chamoun, J, Brown, L, Hambly, B. Myosin binding protein-C: Enigmatic regulator of cardiac contraction. The international journal of biochemistry & cell biology. 2007; 39:2161-6
2006
- White, M, Tchen, A, McCarron, H, Hambly, B, Jeremy, R, Cordwell, S. Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger. Proteomics. 2006; 6:6221-33
- Shen, J, White, M, Husband, A, Hambly, B, Bao, S. Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European journal of pharmacology. 2006; 548:123-8
- Ko, H, Yin, J, Hambly, B, Wyburn, K, Wu, H, Chadban, S, Eris, J. Rapamycin and Sanglifehrin A can inhibit interleukin-18 production from dendritic cells in vitro and in vivo. Immunology and Cell Biology. 2006; 84:A26-A26
- Yin, J, Ko, H, Wyburn, K, Wu, H, Hambly, B, Chadban, S, Eris, J. The role of IL-12 family cytokines in chronic allograft nephropathy. Immunology and Cell Biology. 2006; 84:A12-A12
- Harris, A, Shen, J, Hambly, B, Bao, S. Granulocyte-Macrophage Colony Stimulating Factor contributes to restenosis following experimental endothelial denudation. Atherosclerosis Supplements. 2006; 7:250-250
- White, M, Hambly, B, Jeremy, R, Cordwell, S. Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. Journal of molecular and cellular cardiology. 2006; 40:761-74
- McLachlan, C, Hambly, B, Almsherqi, Z, El Oakley, R, McGuire, M. Transfer of mouse embryonic stem cells to sheep myocardium. Lancet. 2006; 367:301-302
2005
- Ko, H, Yin, J, Hambly, B, Wyburn, K, Wu, H, Chadban, S, Eris, J. Immunosuppressants rapamycin and sanglifehrin A inhibit bioactive IL-18 production by dendritic. Immunology and Cell Biology. 2005; 83:A32-A32
- White, M, Cordwell, S, McCarron, H, Prasan, A, Craft, G, Hambly, B, Jeremy, R. Proteomics of ischemia/reperfusion injury in rabbit myocardium reveals alterations to proteins of essential functional systems. Proteomics. 2005; 5:1395-410
- Ivanova, E, Onyshchenko, O, Christen, R, Zhukova, N, Lysenko, A, Shevchenko, L, Buljan, V, Hambly, B, Kiprianova, E. Oceanimonas smirnovii sp. nov., a novel organism isolated from the Black Sea. Systematic and applied microbiology. 2005; 28:131-6
- Hambly, B, White, M, Cordwell, S, Tchen, A, McCarron, H, Jeremy, R. Reversible ischemia/reperfusion injury correlates with troponin C modification. Biophysical Journal. 2005; 88:315A-315A
2004
- Baumann, B, Liang, H, Sale, K, Hambly, B, Fajer, P. Myosin regulatory domain orientation in skeletal muscle fibers: application of novel electron paramagnetic resonance spectral decomposition and molecular modeling methods. Biophysical journal. 2004; 86:3030-41
- Oakley, C, Hambly, B, Curmi, P, Brown, L. Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy. Cell research. 2004; 14:95-110
- Hambly, B, Liang, H, Sale, K, Baumann, B, Fajer, P. Application of novel EPR and molecular modeling methods to spectroscopic determination of the S1 RLC orientation in muscle fibers. 48th Biophysical Society Annual Meeting. 2004; Feb 14-18, 2004 Baltimore USA; 2004
- Hambly, B, Oakley, C, Brown, L, Curmi, P. Structural analysis of myosin binding protein-C. 48th Annual Meeting of the US Biophysical Society. 2004; Feb 14-18, 2004 Baltimore USA; 2004
- Hambly, B, White, M, Cordwell, S, McCarron, H, Tchen, A, Jeremy, R. Oxygen free radical damage to essential components of the oxidative phosphorylation pathway. Journal of the American College of Cardiology. 2004; 43:254A
- Hambly, B, White, M, Cordwell, S, McCarron, H, Tchen, A, Jeremy, R. Oxygen free radical scavengers prevent damage to proteins of the sarcomere initiated by reversible ischemia/reperfusion injury. Journal of the American College of Cardiology. 2004; 43:255A
- Hambly, B, Harris, A, Shen, J, Bao, S. Neointimal proliferation is reduced in GM-CSF ko mice following arterial injury. American Heart Association Scientific Sessions 2004. 2004; New Orleans, Nov 7-10, 2004; 2004
- Hambly, B, White, M, Cordwell, S, Tchen, A, McCarron, H, Jeremy, R. Modifications to troponin C with brief ischemia/reperfusion injury. American Heart Association Scientific Sessions 2004. 2004; New Orleans, Nov 7-10, 2004; 2004
2003
- McLachlan, C, Jusuf, P, Rummery, N, Kummerfeld, S, Hambly, B, McGuire, M, Turner, V. Tyramide signal amplification enhances the detectable distribution of connexin-43 positive gap junctions across the ventricular wall of the rabbit heart. Archives of histology and cytology. 2003; 66:359-65
- Yin, J, Hambly, B, Bao, S, Painter, D, Bishop, G, Eris, J. Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts. Transplant international : official journal of the European Society for Organ Transplantation. 2003; 16:681-8
- White, M, Cordwell, S, McCarron, H, Tchen, A, Hambly, B, Jeremy, R. Modifications of myosin-regulatory light chain correlate with function of stunned myocardium. Journal of molecular and cellular cardiology. 2003; 35:833-40
2002
- Prasan, A, McCarron, H, Hambly, B, Fermanis, G, Sullivan, D, Jeremy, R. Effect of treatment on ventricular function and troponin I proteolysis in reperfused myocardium. Journal of molecular and cellular cardiology. 2002; 34:401-11
- Yin, J, Pilmore, H, Yan, Y, McCaughan, G, Bishop, G, Hambly, B, Eris, J. Expression of growth arrest-specific gene 6 and its receptors in a rat model of chronic renal transplant rejection. Transplantation. 2002; 73:657-60
- Dedova, I, Dedov, V, Nosworthy, N, Hambly, B, dos Remedios, C. Cofilin and DNase 1 affect the conformation of the small domain of actin. Biophysical Journal. 2002; 82:3134-3143
- Prasan, A, McCarron, H, White, M, McLennan, S, Tchen, A, Hambly, B, Jeremy, R. Duration of ischaemia determines matrix metalloproteinase-2-activation in the reperfused rabbit head. Proteomics. 2002; 2:1204-1210
- Brown, L, Singh, L, Sale, K, Yu, B, Trent, R, Fajer, P, Hambly, B. Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C. European Biophysics Journal With Biophysics Letters. 2002; 31:400-408
2001
- Brown, L, Klonis, N, Sawyer, W, Fajer, P, Hambly, B. Independent movement of the regulatory and catalytic domains of myosin heads revealed by phosphorescence anisotropy. Biochemistry. 2001; 40:8283-91
- Baumann, B, Hambly, B, Hideg, K, Fajer, P. The Regulatory Domain of the Myosin Head Behaves as a Rigid Lever. Biochemistry. 2001; 276:11135-11142
2000
- Mclachlan, C, Jusuf, P, McGuire, M, Yin, J, Driussi, C, Hambly, B. A semi-quantitative PCR method for the detection of low levels if apoptotic DNA fragmentation in a heart failure model. Japanese Journal of Physiology. 2000; 50:281-284
- Yin, J, Chaufour, X, Mclachlan, C, McGuire, M, White, G, King, N, Hambly, B. Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo. Atherosclerosis. 2000; 148(2):365-374
- Mclachlan, C, Jelinek, H, Kummerfeld, S, Rummery, N, Jusuf, P, Hambly, B, McGuire, M. Cross-sectional infarct edge jaggedness does not influence ventricular electrical stability in a rabbit model of late myocardial infarct healing. Redox Report. 2000; 5(2/3):122-123
- Hambly, B, Walsh, J, dos Remedios, C. Electrophoresis - a multidisciplinary and unifying technology. Electrophoresis. 2000; 21:3781-3783
- Yin, J, Mclachlan, C, Chaufour, X, McGuire, M, White, G, Turner, V, King, N, Hambly, B. Growth arrest-specific gene 6 expression in proliferating rabbit vascular smooth muscle cells in vitro and in vivo. Electrophoresis. 2000; 21:3851-3856
- Pulvirenti, T, Yin, J, Chaufour, X, Mclachlan, C, Hambly, B, Bennett, M, Barden, J. P2X (purinergic) receptor redistribution in rabbit aorta following injury to endothelial cells and cholesterol feeding. Journal of Neurocytology. 2000; 29:623-631
