Professor Ron Trent

E:  ron.trent@bosch.org.au T:  +61 2 9515 7514 F:  +61 2 95505412 K25 - Medical Foundation Building The University of Sydney NSW 2006 Australia

• Research interests
• Publications

Research interests

Publications

2010

Luquin, N, Yu, B, Trent, R, Pamphlett, R. DHPLC can be used to detect low-level mutations in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. 2010; 11:76-82

Trent, R. Pathology practice and pharmacogenomics. Pharmacogenomics. 2010; 11:105-11

2009

Luquin, N, Yu, B, Saunderson, R, Trent, R, Pamphlett, R. Genetic variants in the promoter of TARDBP in sporadic amyotrophic lateral sclerosis. Neuromuscular Disorders. 2009; 19:696-700

Trent, R, Yu, B. The future of genetic research in exercise science and sports medicine. Medicine and Sport Science. 2009; 54:187-195

Morahan, J, Yu, B, Trent, R, Pamphlett, R. A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis. 2009; 10:418-429

2008

Luquin, N, Yu, B, Trent, R, Morahan, J, Pamphlett, R. An analysis of the entire SOD1 gene in sporadic ALS. Neuromuscular disorders : NMD. 2008; 18:545-52

Saunderson, R, Yu, B, Trent, R, Pamphlett, R. A comparison of the lengths of androgen receptor triplet repeats in brain and blood in motor neuron diseases. Journal of the neurological sciences. 2008; 267:125-8

Kayser, M, Choi, Y, van Oven, M, Mona, S, Brauer, S, Trent, R, Suarkia, D, Schiefenhovel, W, Stoneking, M. The impact of the Austronesian expansion: Evidence from mtDNA and Y chromosome diversity in the Admiralty Islands of Melanesia. Molecular Biology and Evolution. 2008; 25:1362-1374

Kayser, M, Lao, O, Saar, K, Brauer, S, Wang, X, Nurnberg, P, Trent, R, Stoneking, M. Genorne-wide analysis indicates more Asian than melanesian ancestry of polynesians. American Journal of Human Genetics. 2008; 82:194-198

Le, H, Hinchcliffe, M, Yu, B, Trent, R. Computer-assisted reading of DNA sequences. Methods in Molecular Medicine. 2008; 141:177-197

2007

Saunderson, R, Yu, B, Trent, R, Pamphlett, R. Low yield in screening patients with sporadic motor neuron disease for Kennedy disease. Internal medicine journal. 2007; 37:772-774

Morahan, J, Yu, B, Trent, R, Pamphlett, R. Genetic susceptibility to environmental toxicants in ALS. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2007; 144B:885-90

Myles, S, Hradetzky, E, Engelken, J, Lao, O, Nürnberg, P, Trent, R, Wang, X, Kayser, M, Stoneking, M. Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians. European journal of human genetics. 2007; 15:584-589

Morahan, J, Yu, B, Trent, R, Pamphlett, R. A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. Neurotoxicology. 2007; 28:532-40

Saunderson, R, Yu, B, Trent, R, Pamphlett, R. Are enteroviral receptors different in sporadic motor neuron disease?. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. 2007; 8:26-30

Morahan, J, Yu, B, Trent, R, Pamphlett, R. Are metallothionein genes silenced in ALS?. Toxicology letters. 2007; 168:83-7

2006

Kayser, M, Brauer, S, Cordaux, R, Casto, A, Lao, O, Zhivotovsky, L, Moyse-Faurie, C, Rutledge, R, Schiefenhoevel, W, Gil, D, Lin, A, Underhill, P, Oefner, P, Trent, R, Stoneking, M. Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific. Molecular biology and evolution. 2006; 23:2234-44

Gopinath, B, Trent, R, Yu, B. The unique expression profile of the androgen receptor gene in a rat model of neonatal cardiac hypertrophy. Pathology. 2006; 38:142-4

Trent, R. Diagnosis of the haemoglobinopathies. Clinical Biochemist Reviews. 2006; 27:27-38

Kohonen-Corish, M, Cooper, W, Saab, J, Thompson, J, Trent, R, Millward, M. Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma. The Journal of investigative dermatology. 2006; 126:167-71

Trent, R, Alexander, I. Gene therapy in sport. British journal of sports medicine. 2006; 40:4-5

Li, J, Hayden, M, Warby, S, Durr, A, Morrison, P, Nance, M, Ross, C, Margolis, R, Rosenblatt, A, Squitieri, F, Frati, L, Gómez-Tortosa, E, García, C, Suchowersky, O, Klimek, M, Trent, R, McCusker, E, Novelletto, A, Frontali, M, Paulsen, J, Jones, R, Ashizawa, T, Lazzarini, A, Wheeler, V, Prakash, R, Xu, G, Djoussé, L, Mysore, J, Gillis, T, Hakky, M, Cupples, L, Saint-Hilaire, M, Cha, J, Hersch, S, Penney, J, Harrison, M, Perlman, S, Zanko, A, Abramson, R, Lechich, A, Duckett, A, Marder, K, Conneally, P, Gusella, J, MacDonald, M, Myers, R. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC medical genetics [electronic resource]. 2006; 7:71

Trent, R, Webster, B, Bowden, D, Gilbert, A, Ho, P, Lindeman, R, Lammi, A, Rowell, J, Hinchcliffe, M, Colley, A, Wilson, M, Saleh, M, Blackwell, J, Vicki, P. Complex phenotypes in the haemoglobinopathies: recommendations on screening and DNA testing. Pathology. 2006; 38:507-519

2005

Henderson, J, Withford-Cave, J, Duffy, D, Cole, S, Sawyer, N, Gulbin, J, Hahn, A, Trent, R, Yu, B. The EPAS1 gene influences the aerobic-anaerobic contribution in elite endurance athletes. Human genetics. 2005; 118:416-23

Morahan, J, Yu, B, Trent, R, Pamphlett, R. Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders: official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. 2005; 6:115-7

Trent, R. Oversight and monitoring of clinical research with gene therapy in Australia. The NHMRC has set up the Gene and related Therapies Research Advisory Panel (GTRAP) to oversee gene therapy research. Medical Journal of Australia. 2005; 182:441-2

Yu, B, Sawyer, N, Caramins, M, Yuan, Z, Saunderson, R, Pamphlett, R, Richmond, D, Jeremy, R, Trent, R. Denaturing high performance liquid chromatography: high throughput mutation screening in familial hypertrophic cardiomyopathy and SNP genotyping in motor neurone disease. Journal of clinical pathology. 2005; 58:479-85

Kohonen-Corish, M, Daniel, J, Chan, C, Lin, B, Kwun, S, Dent, O, Dhillon, V, Trent, R, Chapuis, P, Bokey, E. Low microsatellite instability is associated with poor prognosis in stage C colon cancer. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2005; 23:2318-24

Trent, R. Molecular Medicine. Burlington MA: Elsevier Academic Press, 2005.

2004

Jen, J, Wang, H, Lee, H, Sabatti, C, Trent, R, Hannigan, I, Brantberg, K, Halmagyi, G, Nelson, S, Baloh, R. Suggestive linkage to chromosome 6q in families with bilateral vestibulopathy. Neurology. 2004; 63:2376-9

Trent, R, Alexander, I. Gene therapy: applications and progress towards the clinic. Internal medicine journal. 2004; 34:621-5

Gopinath, B, Trent, R, Yu, B. Molecular characterisation of neonatal cardiac hypertrophy and its regression. Cardiology in the young. 2004; 14:498-505

Djoussé, L, Knowlton, B, Hayden, M, Almqvist, E, Brinkman, R, Ross, C, Margolis, R, Rosenblatt, A, Durr, A, Dode, C, Morrison, P, Novelletto, A, Frontali, M, Trent, R, McCusker, E, Gómez-Tortosa, E, Mayo Cabrero, D, Jones, R, Zanko, A, Nance, M, Abramson, R, Suchowersky, O, Paulsen, J, Harrison, M, Yang, Q, Cupples, L, Mysore, J, Gusella, J, MacDonald, M, Myers, R. Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16. Neurogenetics. 2004; 5:109-14

Trent, R, Yu, B, Caramins, M. Challenges for clinical genetic DNA testing. Expert review of molecular diagnostics. 2004; 4:201-8

Saunderson, R, Yu, B, Trent, R, Pamphlett, R. A polymorphism in the poliovirus receptor gene differs in motor neuron disease. Neuroreport. 2004; 15:383-6

Trent, R, Yu, B, Caramins, M. Introduction of molecular genetics and genomics into clinical practice. In: Encyclopedia of Diagnostic Genomics and Proteomics. New York, USA: Marcel Dekker, Inc. 2004. p. 676-681.

Trent, R, Yu, B, Caramins, M. Separation techniques ? Capillary electrophoresis. In: Encyclopedia of Diagnostic Genomics and Proteomics. New York, USA: Marcel Dekker, Inc. 2004. p. 210-215.

Trent, R, Yu, B. Present and prospective applications of genetic DNA testing (Part I). Chinese Journal of Contemporary Pediatrics. 2004; 6:447- 450

Trent, R, Yu, B, Yu, B. Present and prospective applications of genetic DNA testing (Part II). Chinese Journal of Contemporary Pediatrics. 2004; 6:538-541

2003

Li, J, Hayden, M, Almqvist, E, Brinkman, R, Durr, A, Dodé, C, Morrison, P, Suchowersky, O, Ross, C, Margolis, R, Rosenblatt, A, Gómez-Tortosa, E, Cabrero, D, Novelletto, A, Frontali, M, Nance, M, Trent, R, McCusker, E, Jones, R, Paulsen, J, Harrison, M, Zanko, A, Abramson, R, Russ, A, Knowlton, B, Djoussé, L, Mysore, J, Tariot, S, Gusella, M, Wheeler, V, Atwood, L, Cupples, L, Saint-Hilaire, M, Cha, J, Hersch, S, Koroshetz, W, Gusella, J, MacDonald, M, Myers, R. A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. American journal of human genetics. 2003; 73:682-7

Caramins, M, Halliday, G, McCusker, E, Trent, R. Genetically confirmed clinical Huntington's disease with no observable cell loss. Journal of neurology, neurosurgery, and psychiatry. 2003; 74:968-70

Djoussé, L, Knowlton, B, Hayden, M, Almqvist, E, Brinkman, R, Ross, C, Margolis, R, Rosenblatt, A, Durr, A, Dode, C, Morrison, P, Novelletto, A, Frontali, M, Trent, R, McCusker, E, Gómez-Tortosa, E, Mayo, D, Jones, R, Zanko, A, Nance, M, Abramson, R, Suchowersky, O, Paulsen, J, Harrison, M, Yang, Q, Cupples, L, Gusella, J, MacDonald, M, Myers, R. Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. American journal of medical genetics. Part A. 2003; 119:279-82

Trent, R, Williamson, R, Sutherland, G. The "new genetics" and clinical practice. The Medical journal of Australia. 2003; 178:406-9

Orange, S, Painter, D, Horvath, J, Yu, B, Trent, R, Hennessy, A. Placental endothelial nitric oxide synthase localization and expression in normal human pregnancy and pre-eclampsia. Clinical and experimental pharmacology & physiology. 2003; 30:376-81

Trent, R, Williamson, R, Sutherland, G. The new genetics and clinical practice. Medical Journal of Australia. 2003; 178:406-409

Trent, R. Essentially Yours: The Protection of Human Genetic Information in Australia--the impact on clinical practice and the 'new genetics'. The University of New South Wales law journal. 2003; 26:807-812

2002

Brown, L, Singh, L, Sale, K, Yu, B, Trent, R, Fajer, P, Hambly, B. Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C. European Biophysics Journal With Biophysics Letters. 2002; 31:400-408

2001

Dedic, J, Weiss, A, Katahira, J, Yu, B, Trent, R, Urbán, Z. A novel elastin gene mutation (1281delC) in a family with supravalvular aortic stenosis: a mutation cluster within exon 20. Human mutation. 2001; 17:81

2000

Trent, R. Milestones in the human genome project: genesis to postgenome. Medical Journal of Australia. 2000; 173:591-594

Yu, S, Fimmel, A, Fung, D, Trent, R. Polymorphisms in the CAG repeat - a source of error in Huntington disease DNA testing. Clinical Genetics. 2000; 58:469-472

Rivory, L, Qin, H, Clarke, S, Eris, J, Duggin, G, Ray, E, Trent, R, Bishop, J. Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance. European Journal of Clinical Pharmacology. 2000; 56:395-398

McCusker, E, Richards, F, Sillence, D, Wilson, M, Trent, R. Huntington's disease: neurological assessment of potential gene carriers presenting for predictive DNA testing. Journal of Clinical Neuroscience. 2000; 7:38-41

Trent, R, Le, H, Yu, B, Young, G, Bowden, D. DNA testing for haemochromatosis: diagnostic, predictive and screening implications. Pathology. 2000; 32:274-279