Professor Clive Harper

• Competitive grants
• Publications

Current national competitive grants

Publications

2010

Green, A, Garrick, T, Sheedy, D, Blake, H, Shores, E, Harper, C. The Effect of Moderate to Heavy Alcohol Consumption on Neuropsychological Performance as Measured by the Repeatable Battery for the Assessment of Neuropsychological Status. Alcoholism, clinical and experimental research. 2010; 34:443-50

Weickert, C, Sheedy, D, Rothmond, D, Dedova, I, Fung, S, Garrick, T, Wong, J, Harding, A, Sivagnanansundaram, S, Hunt, C, Duncan, C, Sundqvist, N, Tsai, S, Anand, J, Draganic, D, Harper, C. Selection of reference gene expression in a schizophrenia brain cohort. The Australian and New Zealand journal of psychiatry. 2010; 44:59-70

2009

Garrick, T, Sundqvist, N, Dobbins, T, Azizi, L, Harper, C. Factors that influence decisions by families to donate brain tissue for medical research. Cell and tissue banking. 2009; 10:309-15

Glaw, X, Garrick, T, Terwee, P, Patching, J, Blake, H, Harper, C. Brain donation: who and why?. Cell and tissue banking. 2009; 10:241-6

Monoranu, C, Apfelbacher, M, Grünblatt, E, Puppe, B, Alafuzoff, I, Ferrer, I, Al-Saraj, S, Keyvani, K, Schmitt, A, Falkai, P, Schittenhelm, J, Halliday, G, Kril, J, Harper, C, McLean, C, Riederer, P, Roggendorf, W. pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium. Neuropathology and Applied Neurobiology. 2009; 35:329-337

Alexander-Kaufman, K, Harper, C. Transketolase: Observations in alcohol-related brain damage research. The international journal of biochemistry & cell biology. 2009; 41:717-20

Harper, C. The neuropathology of alcohol-related brain damage. Alcohol and Alcoholism. 2009; 44:136-140

Watanabe, H, Henriksson, R, Ohnishi, Y, Ohnishi, Y, Harper, C, Sheedy, D, Garrick, T, Nyberg, F, Nestler, E, Bakalkin, G, Yakovleva, T. FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics. Addiction Biology. 2009; 14:294-297

Kuzmin, A, Bazov, I, Sheedy, D, Garrick, T, Harper, C, Bakalkin, G. Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics. Brain Research. 2009; 1305:S80-S85

Grunblatt, E, Monoranu, C, Apfelbacher, M, Keller, D, Michel, T, Alafuzoff, I, Ferrer, I, Al-Saraj, S, Keyvani, K, Schmitt, A, Falkai, P, Schittenhelm, J, McLean, C, Halliday, G, Harper, C, Deckert, J, Roggendorf, W, Riederer, P. Tryptophan is a marker of human postmortem brain tissue quality. Journal of Neurochemistry. 2009; 110:1400-1408

Dedova, I, Harding, A, Sheedy, D, Garrick, T, Sundqvist, N, Hunt, C, Gillies, J, Harper, C. The importance of brain banks for molecular neuropathological research: the new South wales tissue resource centre experience. International Journal of Molecular Sciences. 2009; 10:366-384

Fein, G, Shimotsu, R, Di Sclafani, V, Barakos, J, Harper, C. Increased White Matter Signal Hyperintensities in Long-Term Abstinent Alcoholics Compared with Nonalcoholic Controls. Alcoholism, clinical and experimental research. 2009; 33:70-8

2008

Henriksson, R, Kuzmin, A, Okvist, A, Harper, C, Sheedy, D, Garrick, T, Yakovleva, T, Bakalkin, G. Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics. Synapse. 2008; 62:829-833

de la Monte, S, Tong, M, Cohen, A, Sheedy, D, Harper, C, Wands, J. Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration. Alcoholism, clinical and experimental research. 2008; 32:1630-1644

Sheedy, D, Garrick, T, Dedova, I, Hunt, C, Miller, R, Sundqvist, N, Harper, C. An Australian Brain Bank: a critical investment with a high return!. Cell and tissue banking. 2008; 9:205-16

Kashem, M, Harper, C, Matsumoto, I. Differential protein expression in the corpus callosum (genu) of human alcoholics. Neurochemistry international. 2008; 53:1-11

Sundqvist, N, Garrick, T, Bishop, I, Harper, C. Reliability of post-mortem psychiatric diagnosis for neuroscience research. The Australian and New Zealand journal of psychiatry. 2008; 42:221-227

Green, A, Garrick, T, Sheedy, D, Blake, H, Shores, A, Harper, C. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary Australian normative data. Australian Journal of Psychology. 2008; 60:72-79

Harper, C, Matsumoto, I. Neuropathology of alcohol-related cognitive alterations. Handbook of Clinical Neurology. 2008; 89:863-872

2007

He, X, Sullivan, E, Stankovic, R, Harper, C, Pfefferbaum, A. Interaction of Thiamine Deficiency and Voluntary Alcohol Consumption Disrupts Rat Corpus Callosum Ultrastructure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007; 32:2207-16

Alexander-Kaufman, K, Harper, C, Wilce, P, Matsumoto, I. Cerebellar Vermis Proteome of Chronic Alcoholic Individuals. Alcoholism, clinical and experimental research. 2007; 31:1286-96

Jeffree, R, Wills, E, Harper, C. An unusual myopathy: Speckled muscle fibers due to enlarged mitochondria. Muscle & nerve. 2007; 36:118-122

Savage, G, Ray, F, Halmagyi, M, Blazely, A, Harper, C. Stable neuropsychological deficits in adult polyglucosan body disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2007; 14:473-7

Hansen, M, Harper, C, Yiannikas, C, McGee-Collett, M. A rare presentation of pigmented villonodular synovitis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2007; 14:386-388

Wheeler, D, Harper, C. Localised reductions in gyrification in the posterior cingulate: Schizophrenia and controls. Progress in neuro-psychopharmacology & biological psychiatry. 2007; 31:319-27

Harper, C. The neurotoxicity of alcohol. Human & experimental toxicology. 2007; 26:251-257

Kashem, M, James, G, Harper, C, Wilce, P, Matsumoto, I. Differential protein expression in the corpus callosum (splenium) of human alcoholics: A proteomics study. Neurochemistry international. 2007; 50:450-9

Harper, C, Cordwell, S, Alexander-Kaufman, K, Matsumoto, I. A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. PROTEOMICS CLINICAL APPLICATIONS. 2007; 1:62-72

Matsuda-Matsumoto, H, Iwazaki, T, Kashem, M, Harper, C, Matsumoto, I. Differential protein expression profiles in the hippocampus of human alcoholics. Neurochemistry international. 2007; 51:370-6

Alexander-Kaufman, K, Dedova, I, Harper, C, Matsumoto, I. Proteome analysis of the dorsolateral prefrontal region from healthy individuals. Neurochemistry international. 2007; 51:433-9

Fuchs, A, Ekstrom, T, Bakalkin, G, Hurd, Y, Sheedy, D, Garrick, T, Harper, C, Okvist, A, Johansson, S, Karimi, M. Validation of endogenous controls for quantitative gene expression analysis: Application on brain cortices of human chronic alcoholics. BRAIN RESEARCH. 2007; 1132:20-28

2006

Shingde, M, Spring, P, Maxwell, A, Wills, E, Harper, C, Dye, D, Laing, N, North, K. Myosin storage (hyaline body) myopathy: A case report. Neuromuscular disorders : NMD. 2006; 16:882-6

Buckley, S, Foley, P, Innes, D, Loh, E, Shen, Y, Williams, S, Harper, C, Tannenberg, A, Dodd, P. GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype. Neurochemistry International. 2006; 49:557-567

Harper, C. Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe!. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2006; 13:1078-82

Bakalkin, G, Marinova, Z, Okvist, A, Bazov, I, Sheedy, D, Garrick, T, Harper, C, Ekstrom, T. Presynaptic dysfunction associated with adaptations in cell suicide machinery in alcoholics: Biochemical evidence. Alcoholism-Clinical and Experimental Research. 2006; 30:55A-55A

Ekstrom, T, Garrick, T, Harper, C, Sheedy, D, Hurd, Y, Bakalkin, G, Johansson, S. Validation of endogenous expression controls for studying gene expression in motor and frontal cortices of human chronic alcoholics. Alcoholism-Clinical and Experimental Research. 2006; 30:150A-150A

Harper, C, Sheedy, D. Brain damage caused by thiamine deficiency - The Australian experience. Alcoholism-Clinical and Experimental Research. 2006; 30:55A-55A

Dedova, I, Garrick, T, Sheedy, D, Hanks, E, Hunt, C, Dedov, V, Harper, C. Brain banking for neuroscience: Helping scientists find causes and cures for neuropsychiatric disorders. Alcoholism-Clinical and Experimental Research. 2006; 30:158A-158A

Matsumoto, I, Alexander-Kaufman, K, Harper, C. Alcohol-induced brain damage: Proteomics on postmortem human brain. Alcoholism-Clinical and Experimental Research. 2006; 30:85A-85A

He, X, Pfefferbaum, A, Sullivan, E, Harper, C. A quantitative morphometric analysis of myelinated fibres in corpus callosum following thiamine deficiency and alcohol exposure in the alcohol-preferring (P) rat. Alcoholism-Clinical and Experimental Research. 2006; 30:159A-159A

Sheedy, D, Hunt, C, Saihara, Y, Garrick, T, Dedova, I, Harper, C. Maintaining quality of the NSW Tissue Resource Centre. Alcoholism-Clinical and Experimental Research. 2006; 30:160A-160A

Garrick, T, Sheedy, D, Blake, H, Green, A, Glaw, X, Harper, C. "Using Our Brains" - Doing it down under. Alcoholism-Clinical and Experimental Research. 2006; 30:158A-158A

Sheedy, D, Garrick, T, Blake, H, Green, A, Hunt, C, Harper, C. Managing the "wealth of information" of an Australian brain tissue bank. Alcoholism-Clinical and Experimental Research. 2006; 30:160A-160A

Alexander-Kaufman, K, Harper, C, Matsumoto, I. A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Alcoholism-Clinical and Experimental Research. 2006; 30:157A-157A

Kashem, A, James, G, Sheedy, D, Harper, C, Wilce, P, Matsumoto, I. Proteomics studies on the corpus callosum of human alcoholic brain. Alcoholism-Clinical and Experimental Research. 2006; 30:142A-142A

Yakovleva, T, Okvist, A, Bazov, I, Martinez, R, Sheedy, D, Garrick, T, Harper, C, Ekstrom, T. Downregulation of the NF-kappaB transcription factors in the prefrontal cortex of human alcoholics. Alcoholism-Clinical and Experimental Research. 2006; 30:157A-157A

Green, A, Garrick, T, Sheedy, D, Blake, H, Harper, C. Alcohol and cognition as measured by the repeatable battery for the assessment of neuropsychological status. Alcoholism-Clinical and Experimental Research. 2006; 30:136A-136A

Garrick, T, Terwee, P, Patching, J, Blake, H, Harper, C. 'Using our Brains' who donates to research and why?. Alcoholism-Clinical and Experimental Research. 2006; 30:218A-218A

Garrick, T, Howell, S, Terwee, P, Redenbach, J, Blake, H, Harper, C. Brain donation for research: Who donates and why?. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2006; 13:524-8

Sheedy, D, Hunt, C, Harper, C. The effect of alcohol and smoking on brain volumes - An autopsy study. Alcoholism-Clinical and Experimental Research. 2006; 30:217A-217A

Green, A, Garrick, T, Sheedy, D, Blake, H, Harper, C. The repeatable battery for the assessment of neuropsychological status (RBANS): Normative data for Australian adults. Alcoholism-Clinical and Experimental Research. 2006; 30:160A-160A

Sheedy, D, Cartwright, M, Harper, C. Data handling - The Hub of a Tissue Resource Centre. Journal of Neural Transmission. 2006; 113:XI-XI

Wheeler, D, Dixon, G, Harper, C. No differences in calcium-binding protein immunoreactivity in the posterior cingulate and visual cortex: schizophrenia and controls. Progress in neuro-psychopharmacology & biological psychiatry. 2006; 30:630-9

Harper, C, Hinton, F, Garrick, T, McLean, C. The Australian Brain Bank Network. Journal of Neural Transmission. 2006; 113:IV-IV

Azizi, L, Garrick, T, Harper, C. Brain donation for research: strong support in Australia. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2006; 13:449-52

Garrick, T, Glaw, X, Harper, C, North, A. The diagnosis is critical for psychiatric brain banks: an interrater reliability study. The Australian and New Zealand journal of psychiatry. 2006. p. 606-7.

Alexander-Kaufman, K, James, G, Sheedy, D, Harper, C, Matsumoto, I. Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Molecular psychiatry. 2006; 11:56-65

2005

Guerrini, I, Thomson, A, Cook, C, McQuillin, A, Sharma, V, Kopelman, M, Reynolds, G, Jauhar, P, Harper, C, Gurling, H. Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS). American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2005; 137B:17-19

Crews, F, Buckley, T, Dodd, P, Ende, G, Foley, N, Harper, C, He, J, Innes, D, Loh, E, Pfefferbaum, A, Zou, J, Sullivan, E. Alcoholic neurobiology: Changes in dependence and recovery. Alcoholism-Clinical and Experimental Research. 2005; 29:1504-1513

Harper, C, Matsumoto, L, Pfefferbaum, A, Adalsteinsson, E, Sullivan, E, Lewohl, J, Dodd, P, Taylor, M, Fein, G, Landman, B. The pathophysiology of ''brain shrinkage'' in alcoholics - Structural and molecular changes and clinical implications. Alcoholism-Clinical and Experimental Research. 2005; 29:1106-1115

Sheedy, D, Fortis, A, Dedova, I, Singde, M, Harper, C. Is tissue pH a true indicator of autopsy brain integrity?. Alcoholism-Clinical and Experimental Research. 2005; 29:122A-122A

Harper, C, Matsumoto, I. Ethanol and brain damage. Current opinion in pharmacology. 2005; 5:73-8

2004

Foley, P, Loh, E, Innes, D, Williams, S, Tannenberg, A, Harper, C, Dodd, P. Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. Annals of the New York Academy of Sciences. 2004; 1025:39-46

Dixon, G, Harper, C. No evidence for selective GABAergic interneuron deficits in the anterior thalamic complex of patients with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. 2004; 28:1045-51

Pfefferbaum, A, Sullivan, E, Adalsteinsson, E, Garrick, T, Harper, C. Postmortem MR imaging of formalin-fixed human brain. NeuroImage. 2004; 21:1585-95

Sarris, M, Scolyer, R, Konopka, M, Thompson, J, Harper, C, Lee, C, Lee, S. Cytoplasmic expression of nm23 predicts the potential for cerebral metastasis in patients with primary cutaneous melanoma. Melanoma research. 2004; 14:23-7

Dixon, G, Garrick, T, Whiteman, I, Sarris, M, Sithamparanathan, S, Harper, C. Characterization of gabaergic neurons within the human medial mamillary nucleus. Neuroscience. 2004; 127:365-72

Cooper, W, Shingde, M, Lee, V, Allan, R, Wills, E, Harper, C. "Rhabdoid meningioma" lacking malignant features. Report of two cases. Clinical neuropathology. 2004; 23:16-20

Harper, C, Scolyer, R. Alcoholism and dementia. In: The Neuropathology of Dementia. 2nd edition. UK: Cambridge Press 2004. p. 427-441.

2003

McKechnie, S, Yang, F, Harper, C, McGee-Collett, M, Henderson, C, Liepnieks, J, Yazaki, M, Benson, M, McLeod, J. Amyloidoma of a spinal root. Neurology. 2003; 61:834-836

Clark, I, Awburn, M, Harper, C, Liomba, N, Molyneux, M. Induction of HO-I in tissue macrophages and monocytes in fatal falciparum malaria and sepsis. Malaria Journal. 2003; 2-online:1-13

Harper, C, Dixon, G, Sheedy, D, Garrick, T. Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Progress In Neuro-Psychopharmacology & Biological Psychiatry. 2003; 27:951-961

Sheedy, D, Garrick, T, Fortis, A, Harper, C. Changing trends in heroin-related deaths in Sydney, Australia-1995 to 1999. American Journal On Addictions. 2003; 12:52-59

Thomas, E, Laws, S, Sutcliffe, J, Harper, C, Dean, B, Mcclean, C, Masters, C, Lautenschlager, N, Gandy, S, Martins, R. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's Disease: No relation to Apolipoprotein E expression or genotype. Biological Psychiatry. 2003; 54:136-141

Clark, I, Awburn, M, Harper, C, Liomba, N, Molyneux, M, Taylor, T, Whitten, R. Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children. Malaria Journal. 2003; 2 (6) online:1-17

Dean, B, Laws, S, Hone, E, Taddei, K, Scarr, E, Harper, C, Mcclean, C, Masters, C, Lautenschlager, N, Gandy, S, Martins, R, Thomas, E. Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological Psychiatry. 2003; 545:616-622

Stankovic, R, Lee, V, Kekic, M, Harper, C. The expression and significance of metallothioneins in murine organs and tissues following mercury vapour exposure. Toxicologic Pathology. 2003; 31:514-523

Harper, C, Garrick, T, Pfefferbaum, A, Adalsteinsson, E, Sullivan, E, Dodd, P, Lewohl, J, Butterworth, R, Matsumoto, I. How important are brain banks for alcohol research?. Alcoholism-Clinical And Experimental Research. 2003; 27 (2):310-323

2002

Sarris, M, Garrick, T, Sheedy, D, Harper, C. Banking for the future: an Australian experience in brain banking. Pathology. 2002; 34:225-229

Halliday, G, Ng, T, Rodriguez, M, Harding, A, Blumbergs, P, Evans, W, Fabian, V, Fryer, J, Gonzales, M, Harper, C, Kalnins, R, Masters, C, McLean, C, Milder, D, Pamphlett, R, Scott, G, Tannenberg, A, Kril, J. Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria. Acta Neuropathologica. 2002; 104:72-78

Laws, S, Hone, E, Taddei, K, Harper, C, Dean, B, McClean, C, Masters, C, Lautenschlager, N, Gandy, S, Martins, R. Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E. Molecular Psychiatry. 2002; 7:886-890

2001

Lo, P, Harper, C, Besser, M. Intracavernous schwannoma of the abducens nerve: a review of the clinical features, radiology and pathology of an unusual case. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2001; 8:357-60

Barnett, M, Prosser, J, Sutton, I, Halmagyi, G, Davies, L, Harper, C, Dalmau, J. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody. Journal of neurology, neurosurgery, and psychiatry. 2001; 70:222-5

Lo, P, Harper, C, Besser, M. Intracavernous schwannoma of the abducens nerve: a review of the clinical features, radiology and pathology of an unuseal case. Journal of Clinical Neuroscience. 2001; 74:643-649

Mann, K, Agartz, I, Harper, C, Shoaf, S, Rawlings, R, Momenan, R, Hommer, D, Pfefferbaum, A, Sullivan, E, Anton, R, Drobes, D, George, M, Bares, R, Machulla, H, Mundle, G, Reimold, M, Heinz, A. Neuroimaging in Alcoholism: Ethanol and Brain Damage. Alcoholism-Clinical and Experimental Research. 2001; 69:409-420

Dixon, G, Harper, C. Quantitative analysis of glutamic acid decarboxylase-immunoreactive neurons in the anterior thalamus of the human brain. Brain Research. 2001; 80:917-925

Huang, W, Harper, C, Evans, S, Newnham, J. Repeated prenatal corticosteriod administration delays myelination of the corpus callosum in fetal sheep. International Journal of Developmental Neuroscience. 2001; 29:111-115

Harper, C, Evans, S, Newnham, J, Dunlop, S, Huang, W. Repeated prenatal corticosteroid administration delays astrocyte and capillary tight junction maturation in fetal sheep. In: International Journal of Developmental Neuroscience. New Delhi, India: Oxford University Press 2001. p. 105-130.

Buckland, M, Scolyer, R, Donellan, M, Brew, S, McGee-Collett, M, Harper, C. Spinal chloroma presenting with triplegia in an aleukaemic patient. Pathology. 2001; 96(7):1998-2004

Harper, C, Duckett, S. Effects of Malnutrition and Alcholism on the Aging Nervous System. Aging Human Nervous System. 2001; 40:151-158

2000

Harper, C. The Neuropathology of Alcohol-Related Brain Damage. Fukushima Medical Journal. 2000; 50:125-129

Dixon, G, Dissanaike, S, Harper, C. Parvalbumin-immunoreactive neurons in the human anteroventral thalamic nucleus. Neuroreport. 2000; 11:97-101

Garrick, R, Sheedy, D, Abernethy, J, Hodda, A, Harper, C. Heroin-related deaths in Sydney, Australia. How common are they?. American Journal on Addictions. 2000; 9:172-178

Le Corre, S, Harper, C, Lopez, P, Ward, P, Catts, S. Increased levels of expression of an NMDARI splice variant in the superior temporal gyrus in schizophrenia. Neuroreport. 2000; 11:983-986