Associate Professor William Phillips
F13 - Anderson Stuart Building
The University of Sydney NSW 2006 Australia |
|
Dr Bill Phillips’ group uses techniques of molecular physiology to investigate the mechanisms that underlie the formation and modification of synapses between nerve and muscle throughout life, and how neuromuscular diseases can interfere with these fundamental processes, leading to weakness.
Current national competitive grants
|
2010 |
|
|
The role of Ten-m3 in patterning ipsilateral retinal projections |
|
| NHMRC Project Grant | $437,050 over 3 years |
|
2009 |
|
|
Postsynaptic signalling systems that sustain the nerve-muscle synapse |
|
| NHMRC Project Grants | $576,000 over 3 years |
2010
- Cole, R, Ghazanfari, N, Ngo, S, Gervasio, O, Reddel, S, Phillips, W. Patient autoantibodies deplete postsynaptic Muscle Specific Kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice. The Journal of physiology. 2010; :
2008
- Brockhausen, J, Cole, R, Gervásio, O, Ngo, S, Noakes, P, Phillips, W. Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse. Developmental neurobiology. 2008; 68:1153-69
- Gervásio, O, Whitehead, N, Yeung, E, Phillips, W, Allen, D. TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy. Journal of Cell Science. 2008; 121:2246-2255
- Cole, R, Reddel, S, Gervásio, O, Phillips, W. Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction. Annals of neurology. 2008; 63:782-9
2007
- Gervásio, O, Armson, P, Phillips, W. Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability. Developmental biology. 2007; 305:262-275
- Ngo, S, Noakes, P, Phillips, W. Neural agrin: a synaptic stabiliser. The international journal of biochemistry & cell biology. 2007; 39:863-867
2005
- Gervasio, O, Phillips, W. Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. Journal of Physiology-London. 2005; 562:673-685
2004
- Ngo, S, Balke, C, Phillips, W, Noakes, P. Neuregulin potentiates agrin-induced acetylcholine receptor clustering in myotubes. Neuroreport. 2004; 15:2501-2505
2003
- Knight, D, D'Arbe, M, Liang, S, Phillips, W, Lavidis, N. Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens. Synapse. 2003; 47:225-235
- Knight, D, D'arbe, M, Liang, S, Phillips, W, Lavidis, N. Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens. Synapse. 2003; 47:225-235
2002
- Phillips, W, Froehner, S. GABARAP and GABAa receptor clustering. Neuron. 2002; 33:1-2
2001
- Liang, S, Jenkins, N, Gilbert, D, Copeland, N, Phillips, W. Structure and chromosome location of the mouse P2X1 purinoceptor gene (P2rx1). Cytogenetics and Cell Genetics. 2001; 15(3):385-400
- Jiang, L, Tsubakihara, M, Heinke, M, Phillips, W, dos Remedios, C, Nosworthy, N, Yao, M. Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics. 2001; 52:863-870
- Liang, S, Phillips, W, Motin, L, Lavidis, N, Moussa, C. Spatial Distribution and developmental appearance of Postjunctional P2X1 Receptors on smooth muscle cells of the mouse vas deferencs. Synapse. 2001; 96(4):1039-1046
2000
- Phillips, W, D'arbe, M, Lavidis, N, Liang, S. Development of fast purinergic transmission in the mouse vas deferens. Synapse. 2000; 37:283-291
- Phillips, W, Han, H, Yang, S. Overexpression of rapsyn modifies the intracellular trafficking of acetylcholine receptors. Journal of Neuroscience Research. 2000; 60:155-163
