Professor Jillian Kril

• Competitive grants
• Publications

Current national competitive grants

Publications

2010

van Eersel, J, Ke, Y, Liu, X, Delerue, F, Kril, J, G��tz, J, Ittner, L. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proceedings of the National Academy of Sciences of the United States of America. 2010; :

Urwin, H, Josephs, K, Rohrer, J, Mackenzie, I, Neumann, M, Authier, A, Seelaar, H, Van Swieten, J, Brown, J, Johannsen, P, Nielsen, J, Holm, I, , F, Dickson, D, Rademakers, R, Graff-Radford, N, Parisi, J, Petersen, R, Hatanpaa, K, White, C, Weiner, M, Geser, F, Van Deerlin, V, Trojanowski, J, Miller, B, Seeley, W, van der Zee, J, Kumar-Singh, S, Engelborghs, S, De Deyn, P, Van Broeckhoven, C, Bigio, E, Deng, H, Halliday, G, Kril, J, Munoz, D, Mann, D, Pickering-Brown, S, Doodeman, V, Adamson, G, Ghazi-Noori, S, Fisher, E, Holton, J, Revesz, T, Rossor, M, Collinge, J, Mead, S, Isaacs, A. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta neuropathologica. 2010; 120:33-41

Van Deerlin, V, Sleiman, P, Martinez-Lage, M, Chen-Plotkin, A, Wang, L, Graff-Radford, N, Dickson, D, Rademakers, R, Boeve, B, Grossman, M, Arnold, S, Mann, D, Pickering-Brown, S, Seelaar, H, Heutink, P, van Swieten, J, Murrell, J, Ghetti, B, Spina, S, Grafman, J, Hodges, J, Spillantini, M, Gilman, S, Lieberman, A, Kaye, J, Woltjer, R, Bigio, E, Mesulam, M, Al-Sarraj, S, Troakes, C, Rosenberg, R, White, C, Ferrer, I, Lladó, A, Neumann, M, Kretzschmar, H, Hulette, C, Welsh-Bohmer, K, Miller, B, Alzualde, A, de Munain, A, McKee, A, Gearing, M, Levey, A, Lah, J, Hardy, J, Rohrer, J, Lashley, T, Mackenzie, I, Feldman, H, Hamilton, R, Dekosky, S, van der Zee, J, Kumar-Singh, S, Van Broeckhoven, C, Mayeux, R, Vonsattel, J, Troncoso, J, Kril, J, Kwok, J, Halliday, G, Bird, T, Ince, P, Shaw, P, Cairns, N, Morris, J, McLean, C, DeCarli, C, Ellis, W, Freeman, S, Frosch, M, Growdon, J, Perl, D, Sano, M, Bennett, D, Schneider, J, Beach, T, Reiman, E, Woodruff, B, Cummings, J, Vinters, H, Miller, C, Chui, H, Alafuzoff, I, Hartikainen, P, Seilhean, D, Galasko, D, Masliah, E, Cotman, C, Tuñón, M, Martínez, M, Munoz, D, Carroll, S, Marson, D, Riederer, P, Bogdanovic, N, Schellenberg, G, Hakonarson, H, Trojanowski, J, Lee, V. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature genetics. 2010; 42:234-9

Loy, C, Kril, J, Trollor, J, Kiernan, M, Kwok, J, Vucic, S, Halliday, G, Hodges, J, , M. The case of a 48 year-old woman with bizarre and complex delusions. Nature reviews. Neurology. 2010; 6:175-9

Mackenzie, I, Neumann, M, Bigio, E, Cairns, N, Alafuzoff, I, Kril, J, Kovacs, G, Ghetti, B, Halliday, G, Holm, I, Ince, P, Kamphorst, W, Revesz, T, Rozemuller, A, Kumar-Singh, S, Akiyama, H, Baborie, A, Spina, S, Dickson, D, Trojanowski, J, Mann, D. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta neuropathologica. 2010; 119:1-4

2009

van Eersel, J, Bi, M, Ke, Y, Hodges, J, Xuereb, J, Gregory, G, Halliday, G, Götz, J, Kril, J, Ittner, L. Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. Journal of neural transmission (Vienna, Austria : 1996). 2009; 116:1243-51

Kril, J. Alzheimer disease: Alzheimer disease neuropathology in the oldest old. Nature Reviews. Neurology. 2009; 5:411-412

Piguet, O, Halliday, G, Creasey, H, Broe, G, Kril, J. Frontotemporal dementia and dementia with Lewy bodies in a case-control study of Alzheimer's disease. International Psychogeriatrics. 2009; 21:688-695

Piguet, O, Double, K, Kril, J, Harasty, J, Macdonald, V, McRitchie, D, Halliday, G. White matter loss in healthy ageing: A postmortem analysis. Neurobiology of aging. 2009; 30:1288-95

Monoranu, C, Apfelbacher, M, Grünblatt, E, Puppe, B, Alafuzoff, I, Ferrer, I, Al-Saraj, S, Keyvani, K, Schmitt, A, Falkai, P, Schittenhelm, J, Halliday, G, Kril, J, Harper, C, McLean, C, Riederer, P, Roggendorf, W. pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium. Neuropathology and Applied Neurobiology. 2009; 35:329-337

Mackenzie, I, Neumann, M, Bigio, E, Cairns, N, Alafuzoff, I, Kril, J, Kovacs, G, Ghetti, B, Halliday, G, Holm, I, Ince, P, Kamphorst, W, Revesz, T, Rozemuller, A, Kumar-Singh, S, Akiyama, H, Baborie, A, Spina, S, Dickson, D, Trojanowski, J, Mann, D. Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathologica. 2009; 117:15-18

Davies, R, Halliday, G, Xuereb, J, Kril, J, Hodges, J. The neural basis of semantic memory: Evidence from semantic dementia. Neurobiology of Aging. 2009; 30:2043-2052

2008

Young, V, Halliday, G, Kril, J. Neuropathologic correlates of white matter hyperintensities. Neurology. 2008; 71:804-11

Karlstrom, H, Brooks, W, Kwok, J, Broe, G, Kril, J, McCann, H, Halliday, G, Schofield, P. Variable phenotype of Alzheimer's disease with spastic paraparesis. Journal of neurochemistry. 2008; 104:573-83

Harris, J, Chimelli, L, Kril, J, Ray, D. Nutritional deficiencies, metabolic disorders and toxins affecting the nervous system. In: Greenfield's Neuropathology. United Kingdom: Hodder Arnold 2008. p. 675-731.

2007

Peisah, C, Snowdon, J, Kril, J, Rodriguez, M. Clinicopathological findings of suicide in the elderly: three cases. Suicide & life-threatening behavior. 2007; 37:648-658

Sutherland, G, Nowak, G, Halliday, G, Kril, J. Tau isoform expression in frontotemporal dementia without tau deposition. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2007; 14:1182-5

Peisah, C, Snowdon, J, Gorrie, C, Kril, J, Rodriguez, M. Investigation of Alzheimer's disease-related pathology in community dwelling older subjects who committed suicide. Journal of affective disorders. 2007; 99:127-32

Kipps, C, Davies, R, Mitchell, J, Kril, J, Halliday, G, Hodges, J. Clinical significance of lobar atrophy in frontotemporal dementia: application of an MRI visual rating scale. Dementia and geriatric cognitive disorders. 2007; 23:334-342

2006

Piguet, O, Cramsie, J, Bennett, H, Kril, J, Lye, T, Corbett, A, Hayes, M, Creasey, H, Broe, G. Contributions of age and alcohol consumption to cerebellar integrity, gait and cognition in non-demented very old individuals. European archives of psychiatry and clinical neuroscience. 2006; 256:504-11

Pickering-Brown, S, Baker, M, Gass, J, Boeve, B, Loy, C, Brooks, W, Mackenzie, I, Martins, R, Kwok, J, Halliday, G, Kril, J, Schofield, P, Mann, D, Hutton, M. Mutations in progranulin explain atypical phenotypes with variants in MAPT. Brain; a journal of neurology. 2006. p. 3124-6.

Davies, R, Kipps, C, Mitchell, J, Kril, J, Halliday, G, Hodges, J. Progression in Frontotemporal Dementia: Identifying a Benign Behavioral Variant by Magnetic Resonance Imaging. Archives of neurology. 2006; 63:1627-1631

Kril, J. Neuropathology of alcohol abuse: A comparison with ageing and Alzheimer's disease. Alcoholism-Clinical and Experimental Research. 2006; 30:51A-51A

Kersaitis, C, Halliday, G, Xuereb, J, Pamphlett, R, Bak, T, Hodges, J, Kril, J. Ubiquitin positive inclusions and early pathology in frontotemporal lobar degeneration and motor neuron disease. Brain Pathology. 2006; 16:S43-S43

Piguet, O, Bennett, H, Waite, L, Kril, J, Creasey, H, Anthony Broe, G, Halliday, G. Preserved cognition and functional independence after a large right posterior cerebral artery infarct: longitudinal clinical and neuropathological findings. Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology. 2006; 12:81-90

Gregory, G, Macdonald, V, Schofield, P, Kril, J, Halliday, G. Differences in regional brain atrophy in genetic forms of Alzheimer's disease. Neurobiology of aging. 2006; 27:387-93

Halliday, G, Song, Y, Creasey, H, Morris, J, Brooks, W, Kril, J. Neuropathology in the S305S tau gene mutation. Brain. 2006; 129:e40

Lye, T, Grayson, D, Creasey, H, Piguet, O, Bennett, H, Ridley, L, Kril, J, Broe, G. Predicting memory performance in normal ageing using different measures of hippocampal size. Neuroradiology. 2006; 48:90-9

Kersaitis, C, Halliday, G, Xuereb, J, Pamphlett, R, Bak, T, Hodges, J, Kril, J. Ubiquitin-positive inclusions and progression of pathology in frontotemporal dementia and motor neurone disease identifies a group with mainly early pathology. Neuropathology and applied neurobiology. 2006; 32:83-91

2005

Davies, R, Hodges, J, Kril, J, Patterson, K, Halliday, G, Xuereb, J. The pathological basis of semantic dementia. Brain; a journal of neurology. 2005; 128:1984-95

Kril, J, Macdonald, V, Patel, S, Png, F, Halliday, G. Distribution of brain atrophy in behavioral variant frontotemporal dementia. Journal of the neurological sciences. 2005; 232:83-90

Eickhoff, S, Walters, N, Schleicher, A, Kril, J, Egan, G, Zilles, K, Watson, J, Amunts, K. High-resolution MRI reflects myeloarchitecture and cytoarchitecture of human cerebral cortex. Human Brain Mapping. 2005; 24:206-215

Graham, A, Davies, R, Xuereb, J, Halliday, G, Kril, J, Creasey, H, Graham, K, Hodges, J. Pathologically proven frontotemporal dementia presenting with severe amnesia. Brain; a journal of neurology. 2005; 128:597-605

Schofield, E, Caine, D, Kril, J, Cordato, N, Halliday, G. Staging disease severity in movement disorder tauopathies: Brain atrophy separates progressive supranuclear palsy from corticobasal degeneration. Movement Disorders. 2005; 20:34-39

Karlstrom, H, Brooks, W, Kwok, J, Kril, J, Halliday, G, Schofield, P. Variable phenotype of Alzheimer's disease with spastic paraparesis. In: Genotype-Proteotype-Phenotype Relationships in Neurodegenerative Disease. Berlin: Springer-Verlag 2005. p. 166.

Halliday, G, Song, Y, Lepar, G, Brooks, W, Kwok, J, Kersaitis, C, Gregory, G, Shepherd, C, Rahimi, F, Schofield, P, Kril, J. Pick bodies in a family with presenilin-1 Alzheimer's disease. Annals of neurology. 2005; 57:139-43

2004

Kersaitis, C, Halliday, G, Kril, J. Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies. Acta neuropathologica. 2004; 108:515-23

Broe, M, Kril, J, Halliday, G. Astrocytic degeneration relates to the severity of disease in frontotemporal dementia. Brain; a journal of neurology. 2004; 127:2214-20

Hodges, J, Davies, R, Xuereb, J, Casey, B, Broe, M, Bak, T, Kril, J, Halliday, G. Clinicopathological correlates in frontotemporal dementia. Annals of neurology. 2004; 56:399-406

Harding, A, Das, A, Kril, J, Brooks, W, Duffy, D, Halliday, G. Identification of families with cortical Lewy body disease. American Journal of Medical Genetics: B: Neuropsychiatric Genetics. 2004; 128B:118-22

Kril, J, Hodges, J, Halliday, G. Relationship between hippocampal volume and CA1 neuron loss in brains of humans with and without Alzheimer''s disease. Neuroscience letters. 2004; 361:9-12

Shepherd, C, Piguet, O, Broe, G, Creasey, H, Waite, L, Brooks, W, Kril, J. Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects. Journal of neuroimmunology. 2004; 148:178-82

Shepherd, C, Gregory, G, Vickers, J, Brooks, W, Kwok, J, Schofield, P, Kril, J, Halliday, G. Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques. Neurobiology of disease. 2004; 15:115-9

Kril, J, Hodges, J, Davies, R, Xuereb, J, Halliday, G. Survival in frontotemporal dementia. In: Research and practice in Alzheimer''s disease. Paris, New York: Serdi Publisher, Springer Publishing Company 2004. p. 215-219.

Kril, J, Halliday, G. Clinicopathological staging of frontotemporal dementia severity: correlation with regional atrophy. Dementia and geriatric cognitive disorders. 2004; 17:311-5

2003

Li, L, Crotty, K, Scolyer, R, Thompson, J, Kril, J, Palmer, A, McCarthy, S. Use of multiple cytometric markers improves discrimination between benign and malignant melanocytic lesions: a study of DNA microdensitometry, karyometry, argyrophilic staining of nucleolar organizer regions and MIB1-Ki67 immunoreactivity. Melanoma Research. 2003; 13:581-586

Halliday, G, Double, K, Macdonald, V, Kril, J. Identifying severely atrophic cortical subregions in Alzheimer's disease. Neurobiology of aging. 2003; 24:797-806

Li, L, Crotty, K, Palmer, A, Kril, J, Scolyer, R, Thompson, J, McCarthy, S. Argyrophilic staining of nucleolar organizer region count and morphometry in benign and malignant melanocytic lesions. American Journal of Dermatopathology. 2003; 25:190-197

Schofield, E, Kersaitis, C, Shepherd, C, Kril, J, Halliday, G. Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. Brain : a journal of neurology. 2003; 126:827-840

Brooks, W, Kwok, J, Kril, J, Broe, G, Blumbergs, P, Tannenberg, A, Lamont, P, Hedges, P, Schofield, P. Alzheimer's disease with spastic paraparesis and 'cotton wool' plaques: two pedigrees with PS-1 exon 9 deletions. Brain : a journal of neurology. 2003; 126:783-91

Broe, M, Hodges, J, Schofield, E, Shepherd, C, Kril, J, Halliday, G. Staging disease severity in pathologically confirmed cases of frontotemporal dementia. Neurology. 2003; 60:1005-1011

Walters, N, Egan, G, Kril, J, Kean, M, Waley, P, Jenkinson, M, Watson, J. In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100:2981-2986

Kril, J. Structural changes in the ageing human brain. In: The Ageing Brain: The Neurobiology and Neuropsychiatry of Ageing. Netherlands: Swets & Zeitlinger 2003. p. 35-48.

Hodges, J, Davies, R, Xuereb, J, Kril, J, Halliday, G. Survival in frontotemporal dementia. Neurology. 2003; 61:349-354

Peisah, C, Kril, J, Hickey, I. Does cerebrovascular disease underpin depression in patients with neurodegenerative disease?. Brain Aging International Journal. 2003; 3(1):21-27

Kril, J, Patel, S, Harding, A, Halliday, G. Hippocampal neuron loss in vascular dementia and Alzheimer's disease. In: Research and Practice in Alzheimer's Disease, Volume 7. NY: Springer 2003. p. 199-203.

2002

Bennett, H, Corbett, A, Gaden, S, Grayson, D, Kril, J, Broe, G. Subcortical vascular disease and functional decline: a 6-year predictor study. Journal of the American Geriatrics Society. 2002; 50:1969-77

Zeng, B, Bruce, D, Kril, J, Ploplis, V, Freedman, B, Brieger, D. Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice. Thrombosis and haemostasis. 2002; 88:805-10

Kril, J, Patel, S, Harding, A, Halliday, G. Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation. Neuropathology. 2002; 103:370-376

Kril, J, Patel, S, Harding, A, Halliday, G. Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss. Journal Of Neurology Neurosurgery And Psychiatry. 2002; 72:747-751

Li, L, Crotty, K, Palmer, A, Kril, J, Scolyer, R, McCarthy, S, Stankovic, R. Diferentiating benign nevi from malignant melanoma using DNA microdensitometry and karyometry and maturation. Analytical And Quantitative Cytology And Histology. 2002; 24:234-243

Walters, N, Egan, G, Kril, J, Kean, M, Waley, P, Jenkinson, M, Watson, J. In vivo identification of human cortical areas using high-resolution MRI: an approach to cerebral structure-function correlation. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002; 100:2981-2986

Li, L, Crotty, K, Palmer, A, Kril, J, Scolyer, R, McCarthy, S. Melanin bleaching in argyrophilic staining of agNORs in pigmented lesions. Analytical And Quantitative Cytology And Histology. 2002; 24:166-172

Halliday, G, Ng, T, Rodriguez, M, Harding, A, Blumbergs, P, Evans, W, Fabian, V, Fryer, J, Gonzales, M, Harper, C, Kalnins, R, Masters, C, McLean, C, Milder, D, Pamphlett, R, Scott, G, Tannenberg, A, Kril, J. Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria. Acta Neuropathologica. 2002; 104:72-78

2001

Smith, M, Kwok, J, McLean, C, Kril, J, Broe, G, Nicholson, G, Cappai, R, Hallupp, M, Cotton, R, Masters, C, Schofield, P, Brooks, W. Variable phenotype of Alzheimer's disease with spastic paraparesis. Annals of Neurology. 2001; 107:247-264

2000

Li, L, Crotty, K, McCarthy, S, Palmer, A, Kril, J. A zonal comparison of MiB1-Ki67 immunoreactivity in benign and malignant melanocytic lesions. American Journal of Dermatopathology. 2000; 22:489-495

Halliday, G, Robinson, S, Shepherd, C, Kril, J. Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms. Clinical and Experimental Pharmacology and Physiology. 2000; 27:1-8

Halliday, G, Shepherd, C, McCann, H, Reid, W, Grayson, D, Broe, A, Kril, J. Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease. Archives of Neurology. 2000; 57:831-836

Li, L, Crotty, K, Kril, J, McCarthy, S, Palmer, A. Effect of melanin bleach on feulgen-DNA microdensitometry in pigmented lesions. Analytical and Quantitative Cytology and Histology. 2000; 22:150-154

Harding, A, Kril, J, Halliday, G. Practical measures to simplify the Braak tangle staging method for routine pathological screening. Acta Neuropathologica. 2000; 99:199-208

Harding, A, Halliday, G, Caine, D, Kril, J. Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain. 2000; 123:141-154