Professor Graham Johnston

E:  graham.johnston@bosch.org.au T:  +61 2 9351 6117 F:  +61 2 9351 2891  Personal Homepage D06 - Blackburn Building The University of Sydney NSW 2006 Australia

• Research interests
• Publications

Research interests

Publications

2010

Skilbeck, K, Johnston, G, Hinton, T. Stress and GABA(A) Receptors. Journal of neurochemistry. 2010; 112:1115-30

2009

Mewett, K, Fernandez, S, Pasricha, A, Pong, A, Devenish, S, Hibbs, D, Chebib, M, Johnston, G, Hanrahan, J. Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic & Medicinal Chemistry. 2009; 17:7156-7173

Chebib, M, Gavande, N, Wong, K, Park, A, Premoli, I, Mewett, K, Allan, R, Duke, R, Johnston, G, Hanrahan, J. Guanidino Acids Act as rho1 GABA(C) Receptor Antagonists. Neurochemical research. 2009; 34:1704-11

Fernandez, S, Nguyen, M, Yow, T, Chu, C, Johnston, G, Hanrahan, J, Chebib, M. The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice. Neurochemical research. 2009; 34:1867-75

Locock, K, Johnston, G, Allan, R. GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid. Neurochemical research. 2009; 34:1698-703

Chebib, M, Hinton, T, Schmid, K, Brinkworth, D, Qian, H, Matos, S, Kim, H, Abdel-Halim, H, Kumar, R, Johnston, G, Hanrahan, J. Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. The Journal of pharmacology and experimental therapeutics. 2009; 328:448-57

Hanrahan, J, Johnston, G. Synthesis of gamma-aminobutyric acid analogs. In: Amino Acids, Peptides and Proteins in Organic Chemistry. Volume 1 - Origins and Synthesis of Amino Acids. Germany: Wiley-VCH 2009. p. 573-689.

2008

Fernandez, S, Mewett, K, Hanrahan, J, Chebib, M, Johnston, G. Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology. 2008; 55:900-7

Kumar, R, Chebib, M, Hibbs, D, Kim, H, Johnston, G, Salam, N, Hanrahan, J. Novel gamma-Aminobutyric Acid rho1 Receptor Antagonists; Synthesis, Pharmacological Activity and Structure-Activity Relationships. Journal of medicinal chemistry. 2008; 51:3825-40

Skilbeck, K, Hinton, T, Johnston, G. Sex-differences and stress: effects on regional high and low affinity [3H]GABA binding. Neurochemistry International. 2008; 52:1212-1219

Abdel-Halim, H, Hanrahan, J, Hibbs, D, Johnston, G, Chebib, M. A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology & Drug Design. 2008; 71:306-327

Skilbeck, K, O'Reilly, J, Johnston, G, Hinton, T. Antipsychotic drug administration differentially affects [(3)H]muscimol and [(3)H]flunitrazepam GABA(A) receptor binding sites. Progress in neuro-psychopharmacology & biological psychiatry. 2008; 32:492-8

Carland, J, Johnston, G, Chebib, M. Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European journal of pharmacology. 2008; 580:27-35

Hinton, T, Chebib, M, Johnston, G. Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic & medicinal chemistry letters. 2008; 18:402-4

Hinton, T, Johnston, G. The role of GABA-A receptors in schizophrenia. Cell Science Reviews. 2008; 5:180-194

2007

Chebib, M, Hanrahan, J, Kumar, R, Mewett, K, Morriss, G, Wooller, S, Johnston, G. (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology. 2007; 52:779-87

Skilbeck, K, O'Reilly, J, Johnston, G, Hinton, T. The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined. Schizophrenia research. 2007; 90:76-80

2006

Skilbeck, K, O'Reilly, J, Johnston, G, Hinton, T. Antipsychotic drug effects on GABA(A) receptors. Australian and New Zealand Journal of Psychiatry. 2006; 40:A125-A125

Hanrahan, J, Mewett, K, Chebib, M, Matos, S, Eliopoulos, C, Crean, C, Kumar, R, Burden, P, Johnston, G. Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic & biomolecular chemistry. 2006; 4:2642-2649

Fernández, S, Wasowski, C, Loscalzo, L, Granger, R, Johnston, G, Paladini, A, Marder, M. Central nervous system depressant action of flavonoid glycosides. European journal of pharmacology. 2006; 539:168-76

Crittenden, D, Park, A, Qiu, J, Silverman, R, Duke, R, Johnston, G, Jordan, M, Chebib, M. Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic & medicinal chemistry. 2006; 14:447-55

Topliss, J, Clark, A, Ernst, E, Hufford, C, Johnston, G, Rimoldi, J, Weimann, B. NATURAL AND SYNTHETIC SUBSTANCES RELATED TO HUMAN HEALTH. . 2006; :

Huang, S, Duke, R, Chebib, M, Sasaki, K, Wada, K, Johnston, G. Mixed antagonistic effects of bilobalide at rho1 GABAC receptor. Neuroscience. 2006; 137:607-17

Johnston, G, Hanrahan, J, Chebib, M, Duke, R, Mewett, K. Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in pharmacology (San Diego, Calif.). 2006; 54:285-316

2005

Schleimer, S, Johnston, G, Henderson, J. Novel oral drug administration in an animal model of neuroleptic therapy. Journal of neuroscience methods. 2005; 146:159-64

Hall, B, Chebib, M, Hanrahan, J, Johnston, G. 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European journal of pharmacology. 2005; 512:97-104

Granger, R, Campbell, E, Johnston, G. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochemical pharmacology. 2005; 69:1101-11

Gibbs, M, Johnston, G. Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks. Neuroscience. 2005; 131:567-76

Johnston, G. GABA(A) receptor channel pharmacology. Current pharmaceutical design. 2005; 11:1867-85

2004

Carland, J, Moorhouse, A, Barry, P, Johnston, G, Chebib, M. Charged residues at the 2'' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. The Journal of biological chemistry. 2004; 279:54153-60

Campbell, E, Chebib, M, Johnston, G. The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochemical pharmacology. 2004; 68:1631-8

Johnston, G, Beart, P. Flavonoids: some of the wisdom of sage?. British journal of pharmacology. 2004; 142:809-10

Huang, S, Duke, R, Chebib, M, Sasaki, K, Wada, K, Johnston, G. Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. European journal of pharmacology. 2004; 494:131-8

Carland, J, Moore, A, Hanrahan, J, Mewett, K, Duke, R, Johnston, G, Chebib, M. Mutations of the 2'' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. Neuropharmacology. 2004; 46:770-81

Hall, B, Chebib, M, Hanrahan, J, Johnston, G. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. European journal of pharmacology. 2004; 491:1-8

Schleimer, S, Hinton, T, Dixon, G, Johnston, G. GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex in schizophrenia. Neuropsychobiology. 2004; 50:226-30

Johnston, G, Chebib, M, Hanrahan, J, Mewett, K, Duke, R, Johnston, G. Ionotropic GABA receptors as therapeutic targets for memory and sleep disorders. Annual Reports in Medicinal Chemistry. 2004; 39:13-23

Johnston, G, Chebib, M, Hanrahan, J, Mewett, K, Duke, R, Johnston, G. Ionotropic GABA receptors as therapeutic targets for memory and sleep disorders. Annual Reports in Medicinal Chemistry. 2004; 39:13-23

Johnston, G, Duke, R, Chebib, M, Hibbs, D, Mewett, K, Johnston, G. Synthesis and resolution of 2-methyl analogues of GABA. Tetrahedron Asymmetry. 2004; 15:1745-1751

Johnston, G, Duke, R, Chebib, M, Hibbs, D, Mewett, K, Johnston, G. Synthesis and resolution of 2-methyl analogues of GABA. Tetrahedron Asymmetry. 2004; 15:1745-1751

2003

Krehan, D, Frølund, B, Ebert, B, Nielsen, B, Krogsgaard-Larsen, P, Johnston, G, Chebib, M. Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorganic & medicinal chemistry. 2003; 11:4891-4896

Johnston, G, Chebib, M, Hanrahan, J, Mewett, K. GABA(C) receptors as drug targets. Current drug targets. CNS and neurological disorders. 2003; 2:260-268

Hanrahan, J, Chebib, M, Davucheron, N, Hall, B, Johnston, G. Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorganic & medicinal chemistry letters. 2003; 13:2281-2284

Chebib, M, Duke, R, Duke, C, Connor, M, Mewett, K, Johnston, G. Convulsant actions of calycanthine. Toxicology and applied pharmacology. 2003; 190:58-64

Krehan, D, Frølund, B, Krogsgaard-Larsen, P, Kehler, J, Johnston, G, Chebib, M. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochemistry international. 2003; 42:561-565

Huang, S, Duke, R, Chebib, M, Sasaki, K, Wada, K, Johnston, G. Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. European journal of pharmacology. 2003; 464:1-8

Johnston, G. Dietary chemicals and brain function. Journal & Proceedings of the Royal Society of New South Wales. 2003; 135:57-71

2002

Topliss, J, Clark, A, Ernst, E, Hufford, C, Johnston, G, Rimoldi, J, Weimann, B. Natural and synthetic substances related to human health. Pure and Applied Chemistry. 2002; 74:1957-1985

Duke, R, Chebib, M, Duke, C, Johnston, G, Roufogalis, B. Ginkgo biloba - food for the brain. New Zealand Pharmacy. 2002; 22:27-33

Chebib, M, Hanrahan, J, Johnston, G. Neurologically-active compounds. . 2002. p. .

2001

Chebib, M, Duke, R, Allan, R, Johnston, G. The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABA(C) receptors. European journal of pharmacology. 2001; 430:185-92

Hall, B, Hanrahan, J, Johnston, G, Hambley, T, Hibbs, D. 6-Methylflavone. Acta Crystallographica Section E-Structure Reports Online. 2001; 264 (1):82-92

Hanrahan, J, Mewett, K, Collins, M, Burden, P, Johnston, G. An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Journal of the Chemical Society-Perkin Transactions 1. 2001; 27:170-174

2000

Duke, R, Collins, M, Balcar, V, Allan, R, Mewett, K, Johnston, G. (+) and (-)-cis-2-Aminomethylcyclopropanecarboxylic Acids show opposite Pharmacology at recombinant p1 and p2 GABAc receptors. Journal of Neurochemistry. 2000; 75 (6):2602-2610

Johnston, G, Kossoff, G. AATSE International Relations Report. Technology & Health. 2000; Sophia-Antipolis France; 1999

Burden, P, Ai, T, Lin, H, Akinci, M, Costandi, M, Hambley, T, Johnston, G. Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand. Synthesis, X-ray analysis and biological activity. Journal of Medicinal Chemistry. 2000; 43:4629-4635

Johnston, G. 'GABA Chemistry: Analogs of GABA as therapeutic and investigational agents. In: GABA in the Nervous System: The View at Fifty Years. : Lippincott Williams & Wilkins 2000. p. 65-79.

Collins, M, Johnston, G. GABA-Activated Ligand GAted Ion Channels: Medicinal Chemistry and Molecular Biology. Journal of Medicinal Chemistry. 2000; 43, No.8:1427-1447

Johnston, G, Chebib, M, Duke, R. Ionotropic GABA Receptors: Ligand Gated Ion Channels. In: Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels. : Elsevier 2000. p. 369-372.

Johnston, G. 'The medicinal chemistry-molecular biology interface: recombinant receptors in the search for new drugs'. Technology & Health. 2000; Paris France; 1999