Associate Professor Renae Monique Ryan
D06 - Blackburn Building
The University of Sydney NSW 2006 Australia |
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Dr. Ryan's research focuses on understanding the way in which proteins move molecules across the cell membrane. In particular, she studies transporters for the neurotransmitters glutamate and glycine that play an important role in regulating normal neurotransmission in the brain. The dysfunction of these transporters has been implicated in disease states such as Alzheimer's disease, schizophrenia and ischemia following a stroke. Dr. Ryan uses a variety of biochemical and molecular techniques to try and understand the mechanism of transport and also how drugs interact with these proteins.
Current national competitive grants
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2009 |
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Drug binding Sites on Glycine Transporters |
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| NHMRC Project Grants | $478,500 over 3 years |
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The Molecular mechanism of ion-coupled transport in the brain |
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| NHMRC Career Development Award | $370,000 over 4 years |
2009
- Edington, A, McKinzie, A, Reynolds, A, Kassiou, M, Ryan, R, Vandenberg, R. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonyl-glycine inhibition of glycine transport. The Journal of biological chemistry. 2009; 284:36424-30
- Ryan, R, Compton, E, Mindell, J. Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii. Journal of Biological Chemistry. 2009; 284:17540-17548
- Huang, S, Ryan, R, Vandenberg, R. The role of cation binding in determining substrate selectivity of glutamate transporters. The Journal of biological chemistry. 2009; 284:4510-5
2008
- Vandenberg, R, Huang, S, Ryan, R. Slips, leaks and channels in glutamate transporters. Channels. 2008; 2:51-58
2007
- Ryan, R, Mindell, J. The uncoupled chloride conductance of a bacterial glutamate transporter homolog. Nature structural & molecular biology. 2007; 14:365-371
- Boudker, O, Ryan, R, Yernool, D, Shimamoto, K, Gouaux, E. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature. 2007; 445:387-393
2005
- Vandenberg, R, Ryan, R. How and why are channels in transporters?. Science's STKE [electronic resource]: signal transduction knowledge environment. 2005; 2005:pe17
- Ryan, R, Vandenberg, R. A channel in a transporter. Clinical and experimental pharmacology & physiology. 2005; 32:1-6
2004
- Vandenberg, R, Ju, P, Aubrey, K, Ryan, R, Mitrovic, A. Allosteric modulation of neurotransmitter transporters at excitatory synapses. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2004; 23:1-11
- Jennings, E, Ryan, R, Christie, M. Effects of sumatriptan on rat medullary dorsal horn neurons. Pain. 2004; 111:30-7
- Ryan, R, Mitrovic, A, Vandenberg, R. The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway. The Journal of biological chemistry. 2004; 279:20742-51
2003
- Ryan, R, Mitrovic, A, Vandenberg, R. Site-directed mutagenesis in the study of membrane transporters. Methods in molecular biology. 2003; 227:97-108
2002
- Borgland, S, Connor, M, Ryan, R, Ball, H, Christie, M. Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of physiology. 2002; 539:433-44
