Associate Professor Stephen Twigg

E:  stephen.twigg@bosch.org.au T:  +61 2 9515 6150 F:  +61 2 9516 1273 C39 - Royal Prince Alfred Hospital The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Thomson, S, McLennan, S, Hennessy, A, Boughton, P, Bonner, J, Zoellner, H, Yue, D, Twigg, S. A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia. 2010; 53:572-83

Tu, E, Bagnall, R, Duflou, J, Lynch, M, Twigg, S, Semsarian, C. Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human pathology. 2010; 41:392-400

Tu, E, Twigg, S, Semsarian, C. Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International journal of cardiology. 2010; 138:91-3

2009

Wang, X, McLennan, S, Allen, T, Tsoutsman, T, Semsarian, C, Twigg, S. Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American journal of physiology. Cell physiology. 2009; 297:C1490-500

Baxter, R, Twigg, S. Actions of IGF binding proteins and related proteins in adipose tissue. Trends in endocrinology and metabolism: TEM. 2009; 20:499-505

Min, D, Lyons, J, Bonner, J, Twigg, S, Yue, D, McLennan, S. Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology. 2009; 297:F1229-F1237

Cheung, N, Conn, J, d'Emden, M, Gunton, J, Jenkins, A, Ross, G, Sinha, A, Andrikopoulos, S, Colagiuri, S, Twigg, S, , A. Position statement of the Australian Diabetes Society: individualisation of glycated haemoglobin targets for adults with diabetes mellitus. The Medical Journal of Australia. 2009; 191:339-344

Wong, J, McLennan, S, Molyneaux, L, Min, D, Twigg, S, Yue, D. Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia. 2009; 52:1953-61

Loy, C, Twigg, S. Growth factors, AGEing, and the diabetes link in Alzheimer's disease. Journal of Alzheimer's Disease. 2009; 16:823-831

Chan, S, Schedlich, L, Twigg, S, Baxter, R. Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. American Journal of Physiology: Endocrinology and Metabolism. 2009; 296:E654-E663

Liu, Y, Min, D, Bolton, T, Nubé, V, Twigg, S, Yue, D, McLennan, S. Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes care. 2009; 32:117-9

2008

Wong, J, Molyneaux, L, Constantino, M, Twigg, S, Yue, D. Timing is Everything: Age of Onset Influences Long Term Retinopathy Risk in Type 2 Diabetes, Independent of Traditional Risk Factors. Diabetes care. 2008; 31:1985-90

Brooks, B, Franjic, B, Ban, C, Swaraj, K, Yue, D, Celermajer, D, Twigg, S. Diastolic dysfunction and abnormalities of the microcirculation in type 2 diabetes. Diabetes, obesity & metabolism. 2008; 10:739-46

Tan, J, McLennan, S, Song, W, Lo, L, Bonner, J, Williams, P, Twigg, S. Connective tissue growth factor inhibits adipocyte differentiation. American journal of physiology. Cell physiology. 2008; 295:C740-51

Brooks, B, Heffernan, S, Thomson, S, McLennan, S, Twigg, S, Yue, D. The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes. American journal of primatology. 2008; 70:796-802

Tu, E, Twigg, S, Duflou, J, Semsarian, C. Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. The Medical Journal of Australia. 2008; 188:699-702

Brooks, B, McLennan, S, Twigg, S, Yue, D. Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes & Vascular Disease Research. 2008; 5:30-35

Ban, C, Twigg, S. Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers. Vascular health and risk management. 2008; 4:575-596

McGill, M, Molyneaux, L, Twigg, S, Yue, D. The metabolic syndrome in type 1 diabetes: does it exist and does it matter?. Journal of Diabetes and its Complications. 2008; 22:18-23

McLennan, S, Bonner, J, Milne, S, Lo, L, Charlton, A, Kurup, S, Jia, J, Yue, D, Twigg, S. The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration. 2008; 16:706-713

Thomson, S, McLennan, S, Kirwan, P, Heffernan, S, Hennessy, A, Yue, D, Twigg, S. Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of diabetes and its complications. 2008; 22:284-94

Wong, J, Molyneaux, L, Zhao, D, Constantino, M, Gray, R, Twigg, S, Xu, Z, Yue, D. Different accelerators to early-onset Type 2 diabetes: a comparison of Anglo-Celtic and Chinese patients. Journal of diabetes and its complications. 2008; 22:389-94

Xie, L, Galettis, A, Morris, J, Jackson, C, Twigg, S, Gallery, E. Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes/metabolism research and reviews. 2008; 24:294-300

2007

Jamieson, H, Cogger, V, Twigg, S, McLennan, S, Warren, A, Cheluvappa, R, Hilmer, S, Fraser, R, de Cabo, R, Le Couteur, D. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia. 2007; 50:1969-76

Qi, W, Chen, X, Twigg, S, Zhang, Y, Gilbert, R, Kelly, D, Pollock, C. The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology (Carlton, Vic.). 2007; 12:267-274

Twigg, S, Kamp, M, Davis, T, Neylon, E, Flack, J, , A, , A. Prediabetes: a position statement from the Australian Diabetes Society and Australian Diabetes Educators Association. The Medical journal of Australia. 2007; 186:461-465

Xu, L, McLennan, S, Lo, L, Natfaji, A, Bolton, T, Liu, Y, Twigg, S, Yue, D. Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. Diabetes care. 2007; 30:378-380

Zoellner, I, Twigg, S, Yue, D, Bonner, J, Hennessy, A, Thomson, S, McLennan, S. Dysregulated inflammation predicts reduced connective tissue growth factor expression in a baboon wound healing model of type 1 diabetes. Diabetologia. 2007; 50:S490-S491

McLennan, S, McGill, M, Twigg, S, Yue, D. Improving wound-healing outcomes in diabetic foot ulcers. Expert Review of Endocrinology and Metabolism. 2007; 2:205-213

2006

Wong, J, Molyneaux, L, Constantino, M, Twigg, S, Yue, D. The metabolic syndrome in type 2 diabetes: When does it matter?. Diabetes, obesity & metabolism. 2006; 8:690-7

Qi, W, Chen, X, Holian, J, Mreich, E, Twigg, S, Gilbert, R, Pollock, C. Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American journal of physiology. Renal physiology. 2006; 291:F1070-7

Ong, C, Molyneaux, L, Constantino, M, Twigg, S, Yue, D. Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes. Diabetes care. 2006; 29:2361-4

Ferreira, S, Ramachandran, A, Aschner, P, Chan, J, Hancu, N, Baik, S, Ilkova, H, Twigg, S, Gagliardino, J. Basic characteristics and treatment regimens in people with type 1 diabetes in the international diabetes management practices study (IDMPS). Diabetologia. 2006; 49:557-557

Burns, W, Twigg, S, Forbes, J, Pete, J, Tikellis, C, Thallas-Bonke, V, Thomas, M, Cooper, M, Kantharidis, P. Connective Tissue Growth Factor Plays an Important Role in Advanced Glycation End Product-Induced Tubular Epithelial-to-Mesenchymal Transition: Implications for Diabetic Renal Disease. Journal of the American Society of Nephrology : JASN. 2006; 17:2484-94

Gagliardino, J, Aschner, P, Baik, S, Chan, J, Ferreira, S, Hancu, N, Ilkova, H, Twigg, S, Ramachandran, A. Hypoglycaemia and self-monitoring blood glucose are predictive factors for achieving glycaemic control in people with diabetes. Diabetologia. 2006; 49:246-247

Hancu, N, Baik, S, Ferreira, S, Gagliardino, J, Chan, J, Aschner, P, Ramachandran, A, Twigg, S, Ilkova, H. Basic characteristics and treatment regimens in people with type 2 diabetes in the international diabetes management practices study (IDMPS). Diabetologia. 2006; 49:203-204

McLennan, S, Jia, J, Milne, S, Lo, L, Bonner, J, Yue, D, Twigg, S. Propolis, the anti-inflammatory bee hive protectant improves wound healing in experimental diabetes. Diabetologia. 2006; 49:684-685

Ramachandran, A, Aschner, P, Chan, J, Hancu, N, Baik, S, Ferreira, S, Ilkova, H, Twigg, S, Gagliardino, J. Complications and cardiovascular risk factors in people with type 1 diabetes in the International Diabetes Management Practices Study (IDMPS). Diabetologia. 2006; 49:626-627

Samaras, K, McElduff, A, Twigg, S, Proietto, J, Prins, J, Welborn, T, Zimmet, P, Chisholm, D, Campbell, L. Insulin levels in insulin resistance: phantom of the metabolic opera?. The Medical journal of Australia. 2006; 185:159-61

Qi, W, Chen, X, Holian, J, Twigg, S, Gilbert, R, Pollock, C. Transforming growth factor-beta1 differentially mediates fibrosis and immunomodulation in kidney tubular cells. Nephrology Dialysis Transplantation. 2006; 21:32-32

Qi, W, Chen, X, Polhill, T, Sumual, S, Twigg, S, Gilbert, R, Pollock, C. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American journal of physiology. Renal physiology. 2006; 290:F703-9

Qi, W, Chen, X, Twigg, S, Polhill, T, Gilbert, R, Pollock, C. Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney international. 2006; 69:989-95

Johnson, P, Burgess, J, Ge, Q, Poniris, M, Boustany, S, Twigg, S, Black, J. Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. American journal of respiratory and critical care medicine. 2006; 173:32-41

Burgess, J, Ge, Q, Poniris, M, Boustany, S, Twigg, S, Black, J, Johnson, P. Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. American journal of physiology. Lung cellular and molecular physiology. 2006; 290:L153-61

2005

Chan, S, Twigg, S, Firth, S, Baxter, R. Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. The Journal of clinical endocrinology and metabolism. 2005; 90:6588-95

Dean, R, Balding, L, Candido, R, Burns, W, Cao, Z, Twigg, S, Burrell, L. Connective tissue growth factor and cardiac fibrosis after myocardial infarction. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2005; 53:1245-56

Qi, W, Twigg, S, Chen, X, Polhill, T, Poronnik, P, Gilbert, R, Pollock, C. Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis. American Journal of Physiology-Renal Physiology. 2005; 288:F800-F809

Hart, S, Twigg, S, Abraham, S, Russell, J. The practical management of patients with type 1 diabetes requireing inpatient care due to an eating disorder. Practical Diabetes International. 2005; 22:165-170

2004

McLennan, S, Wang, X, Moreno, V, Yue, D, Twigg, S. Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology. 2004; 145:5646-55

Galettis, A, Campbell, S, Morris, J, Jackson, C, Twigg, S, Gallery, E. Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by type 1 diabetes but not by gestational diabetes. Diabetes care. 2004; 27:2514-5

Twigg, S, Cooper, M. The time has come to target connective tissue growth factor in diabetic complications. Diabetologia. 2004; 47:965-8

Twigg, S, Omari, A. Hypoglycaemia in type 2 diabetes: diagnosis and management. Diabetes Management Journal. 2004; 7:12-13

2003

Cooper, L, Clifton Bligh, R, Nery, M, Figtree, G, Hibbert, E, Twigg, S, Robinson, B. Vitamin D supplementation and bone mineral density in early postmenopausal women. American Journal Of Clinical Nutrition. 2003; 77(5):1324-1329

Candido, R, Forbes, J, Thomas, M, Thallas, V, Dean, R, Burns, W, Tikellis, C, Ritchie, R, Twigg, S, Cooper, M, Burrell, L. A breaker of advanced Glycation end products attenuates diabetes-induced myocardial structural changes. Circulation Research. 2003; 92:785-792

Tikellis, C, Cooper, M, Twigg, S, Burns, W, Tolcos, M. Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology. 2003; 145(2):860-866

2002

Twigg, S, Cao, Z, MCLennan, S, Burns, W, Brammar, G, Forbes, J, Cooper, M. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology. 2002; 143:4907-4915

Dwight, T, Kytölä, S, Teh, B, Theodosopoulos, G, Richardson, A, Philips, J, Twigg, S, Delbridge, L, Marsh, D, Nelson, A, Larsson, C, Robinson, B. Genetic analysis of lithium-associated parathyroid tumors. European journal of endocrinology / European Federation of Endocrine Societies. 2002; 146:619-27

Twigg, S, Tsubaki, J, Hwa, V, Rosenfeld, R. Differential Activation of the IGF Binding Protein-3 Promoter by Butyrate in Prostate Cancer Cells. Endocrinology. 2002; 143(5):1778-1788

Twigg, S, Candido, R, Jandeleit-Dahm, K, Zemin, C, Nesteroff, S, Burns, W, Cooper, M, Allen, T, Dilley, R. Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient Mice. Circulation. 2002; 106:246-253

2001

Tsubaki, J, Choi, W, Ingermann, A, Twigg, S, Kim, H, Rosenfeld, R, Oh, Y. Effects of sodium butyrate on expression of members of the IGF-binding protein superfamily in human mammary epithelial cells. Journal of Endocrinology. 2001; Issue 4:1-4

Twigg, S, Chen, M, Joly, A, Chakrapani, S, Tsubaki, J, Kim, H, Oh, Y, Rosenfeld, R. Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extacellular matrix in diabetes mellitus. Endocrinology. 2001. p. .

2000

Twigg, S, Kiefer, M, Zapf, J, Baxter, R. A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit. Endocrinology. 2000; 141:454-457

Dwight, T, Twigg, S, Delbridge, L, Wong, F, Farnebo, F, Richardson, A, Nelson, A, Zedenius, J, Philips, J, Larsson, C, Teh, B, Robinson, B. Loss of heterozygosity in sporadic parathyroid tumours: involvement iin chromosome 1 and the MEN1 gene locus in 11q13. Clinical Endocrinology. 2000; 53:85-92

Dwight, T, Twigg, S, Delbridge, L, Wong, F, Farnebo, F, Richardson, A, Nelson, A, Zedenius, J, Philips, J, Larsson, C, Teh, B, Robinson, B. Loss of heterozygosity in sporadic parathyroid tumours: involvement of chromosome 1 and the MEN1 gene locus in 11q13. Clinical Endocrinology. 2000; 53:85-`92

Twigg, S, Hardman, K, Baxter, R. A purified bovine serum albumin preparation contains an insulin-like growth factor (IGF) binding protein-3 fragment that forms ternary complexes selectively with IGF-II and the acid-labile subunit. Growth Hormone & IGF Research. 2000; 10:215-223