Dr Susan McLennan

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Thomson, S, McLennan, S, Hennessy, A, Boughton, P, Bonner, J, Zoellner, H, Yue, D, Twigg, S. A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia. 2010; 53:572-83

2009

Wang, X, McLennan, S, Allen, T, Tsoutsman, T, Semsarian, C, Twigg, S. Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American journal of physiology. Cell physiology. 2009; 297:C1490-500

Min, D, Lyons, J, Bonner, J, Twigg, S, Yue, D, McLennan, S. Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology. 2009; 297:F1229-F1237

Wong, J, McLennan, S, Molyneaux, L, Min, D, Twigg, S, Yue, D. Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia. 2009; 52:1953-61

Liu, Y, Min, D, Bolton, T, Nubé, V, Twigg, S, Yue, D, McLennan, S. Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes care. 2009; 32:117-9

2008

Tan, J, McLennan, S, Song, W, Lo, L, Bonner, J, Williams, P, Twigg, S. Connective tissue growth factor inhibits adipocyte differentiation. American journal of physiology. Cell physiology. 2008; 295:C740-51

Brooks, B, Heffernan, S, Thomson, S, McLennan, S, Twigg, S, Yue, D. The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes. American journal of primatology. 2008; 70:796-802

Brooks, B, McLennan, S, Twigg, S, Yue, D. Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes & Vascular Disease Research. 2008; 5:30-35

McLennan, S, Min, D, Yue, D. Matrix metalloproteinases: their role in poor wound healing in diabetes. Wound Practice & Research. 2008; 16:116-120

McLennan, S, Bonner, J, Milne, S, Lo, L, Charlton, A, Kurup, S, Jia, J, Yue, D, Twigg, S. The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration. 2008; 16:706-713

Thomson, S, McLennan, S, Kirwan, P, Heffernan, S, Hennessy, A, Yue, D, Twigg, S. Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of diabetes and its complications. 2008; 22:284-94

2007

Jamieson, H, Cogger, V, Twigg, S, McLennan, S, Warren, A, Cheluvappa, R, Hilmer, S, Fraser, R, de Cabo, R, Le Couteur, D. Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia. 2007; 50:1969-76

McLennan, S, Kelly, D, Schache, M, Waltham, M, Dy, V, Langham, R, Yue, D, Gilbert, R. Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy?. Kidney international. 2007; 72:481-8

Xu, L, McLennan, S, Lo, L, Natfaji, A, Bolton, T, Liu, Y, Twigg, S, Yue, D. Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. Diabetes care. 2007; 30:378-380

Zoellner, I, Twigg, S, Yue, D, Bonner, J, Hennessy, A, Thomson, S, McLennan, S. Dysregulated inflammation predicts reduced connective tissue growth factor expression in a baboon wound healing model of type 1 diabetes. Diabetologia. 2007; 50:S490-S491

McLennan, S, McGill, M, Twigg, S, Yue, D. Improving wound-healing outcomes in diabetic foot ulcers. Expert Review of Endocrinology and Metabolism. 2007; 2:205-213

2006

McLennan, S, Jia, J, Milne, S, Lo, L, Bonner, J, Yue, D, Twigg, S. Propolis, the anti-inflammatory bee hive protectant improves wound healing in experimental diabetes. Diabetologia. 2006; 49:684-685

Min, D, Lyons, J, Jia, J, Lo, L, McLennan, S. 2-Methoxy-2,4-diphenyl-3(2H)-furanone-labeled gelatin zymography and reverse zymography: a rapid real-time method for quantification of matrix metalloproteinases-2 and -9 and tissue inhibitors of metalloproteinases. Electrophoresis. 2006; 27:357-64

Young, A, McLennan, S, Smith, M, Smith, S, Cake, M, Read, R, Melrose, J, Sonnabend, D, Flannery, C, Little, C. Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis research & therapy. 2006; 8:R41

Chen, C, Williams, P, Heffernan, S, Nicks, J, McLennan, S, Cooney, G, Sullivan, D, Yue, D, Turtle, J. The effects of fish oil on hepatic insulin receptors in streptozocin diabetic rats and gold-thioglucose induced obese mice. . 2006; :

2004

McLennan, S, Wang, X, Moreno, V, Yue, D, Twigg, S. Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology. 2004; 145:5646-55

2002

Twigg, S, Cao, Z, MCLennan, S, Burns, W, Brammar, G, Forbes, J, Cooper, M. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology. 2002; 143:4907-4915

McLennan, S, Kelly, D, Cox, A, Cao, Z, Lyons, J, Yue, D, Gilbert, R. Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases. Diabetologia. 2002; 45:268-275

McLennan, S, Martell, S, Yue, D. Effects of mesangnium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. Diabetes. 2002; 51:2612-2618

Birrell, A, Heffernan, S, Kirwan, P, McLennan, S, Gillin, A, Yue, D. The effects of aminoguanidine on renal changes in a baboon model of type 1 diabetes. Journal Of Diabetes And Its Complications. 2002; 16:301-309

Birrell, A, Heffernan, S, Kirwan, P, McLennan, S, Gillies, M, Yue, D. The effects of aminoguanidine on renal changes in a baboon model of Type 1 diabetes. Journal Of Diabetes And Its Complications. 2002; 16:301-309

2000

McLennan, S, Martell, S, Yue, D. High glucose concentration inhibits the expression of membrane type metalloproteinase by mesangial cells: possible role in mesangium accumulation. Diabetologia. 2000; 43:642-648

McLennan, S, Fisher, E, Martell, S, Death, A, Williams, P, Lyons, J, Yue, D. Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: possible role in diabetic nephropathy. Kidney International. 2000; 58 (Suppl. 77):S-81-S-87

Birrell, A, Heffernan, S, Ansselin, A, McLennan, S, Church, D, Gillin, A, Yue, D. Functional and structural abnormalities in the nerves of Type 1 diabetic baboons: aminoguanidine treatment does not improve nerve function. Diabetologia. 2000; 43:110-116