Professor Anthony Weiss

T:  +61 2 9351 3464 F:  +61 2 9351 4726 G08 - Biochemistry Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Wise, S, Byrom, M, Waterhouse, A, Bannon, P, Ng, M, Weiss, A. A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties. Acta biomaterialia. 2010; :

Almine, J, Bax, D, Mithieux, S, Nivison-Smith, L, Rnjak, J, Waterhouse, A, Wise, S, Weiss, A. Elastin-based materials. Chemical Society reviews. 2010; :

Tu, Y, Wise, S, Weiss, A. Stages in tropoelastin coalescence during synthetic elastin hydrogel formation. Micron (Oxford, England : 1993). 2010; 41:268-72

Bax, D, McKenzie, D, Weiss, A, Bilek, M. The linker-free covalent attachment of collagen to plasma immersion ion implantation treated polytetrafluoroethylene and subsequent cell-binding activity. Biomaterials. 2010; 31:2526-34

Tu, Y, Weiss, A. Transient tropoelastin nanoparticles are early-stage intermediates in the coacervation of human tropoelastin whose aggregation is facilitated by heparan sulfate and heparin decasaccharides. Matrix biology : journal of the International Society for Matrix Biology. 2010; 29:152-9

Annabi, N, Mithieux, S, Weiss, A, Dehghani, F. Cross-linked open-pore elastic hydrogels based on tropoelastin, elastin and high pressure CO(2). Biomaterials. 2010; 31:1655-65

Nivison-Smith, L, Rnjak, J, Weiss, A. Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications. Acta biomaterialia. 2010; 6:354-9

2009

Bax, D, McKenzie, D, Weiss, A, Bilek, M. Linker-free covalent attachment of the extracellular matrix protein tropoelastin to a polymer surface for directed cell spreading. Acta biomaterialia. 2009; 5:3371-81

Rnjak, J, Li, Z, Maitz, P, Wise, S, Weiss, A. Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin. Biomaterials. 2009; 30:6469-77

Bax, D, Rodgers, U, Bilek, M, Weiss, A. Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3. The Journal of biological chemistry. 2009; 284:28616-23

Annabi, N, Mithieux, S, Boughton, E, Ruys, A, Weiss, A, Dehghani, F. Synthesis of highly porous crosslinked elastin hydrogels and their interaction with fibroblasts in vitro. Biomaterials. 2009; 30:4550-7

Dyksterhuis, L, Carter, E, Mithieux, S, Weiss, A. Tropoelastin as a thermodynamically unfolded premolten globule protein: The effect of trimethylamine N-oxide on structure and coacervation. Archives of biochemistry and biophysics. 2009; 487:79-84

Yang, S, Xie, Y, Yang, W, Zheng, R, Stevens, F, Korkmaz, E, Weiss, A, Ringer, S, Braet, F. In vitro studies of cells grown on the superconductor PrO(x)FeAs. Micron (Oxford, England : 1993). 2009; 40:476-479

Naumann, C, Mithieux, S, Szekely, D, Tu, Y, Weiss, A, Kuchel, P. "Setting paint" analogy for the hydrophobic self-association of tropoelastin into elastin-like hydrogel. Biopolymers. 2009; 91:321-330

Taddese, S, Weiss, A, Jahreis, G, Neubert, R, Schmelzer, C. In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24. Matrix biology : journal of the International Society for Matrix Biology. 2009; 28:84-91

Yin, Y, Wise, S, Nosworthy, N, Waterhouse, A, Bax, D, Youssef, H, Byrom, M, Bilek, M, McKenzie, D, Weiss, A, Ng, M. Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials. 2009; 30:1675-1681

Wise, S, Weiss, A. Tropoelastin. The international journal of biochemistry & cell biology. 2009; 41:494-7

Mithieux, S, Tu, Y, Korkmaz, E, Braet, F, Weiss, A. In situ polymerization of tropoelastin in the absence of chemical cross-linking. Biomaterials. 2009; 30:431-5

Wise, S, Mithieux, S, Weiss, A. Engineered tropoelastin and elastin-based biomaterials. Advances in Protein Chemistry and Structural Biology. 2009; 78:1-24

Yin, Y, Fisher, K, Nosworthy, N, Bax, D, Rubanov, S, Gong, B, Weiss, A, McKenzie, D, Bilek, M. Covalently Bound Biomimetic Layers on Plasma Polymers with Graded Metallic Interfaces for in vivo Implants. Plasma Processes and Polymers. 2009; 6:658-666

Annabi, N, Mithieux, S, Weiss, A, Dehghani, F. The fabrication of elastin-based hydrogels using high pressure CO(2). Biomaterials. 2009; 30:1-7

2008

Tu, Y, Weiss, A. Glycosaminoglycan-mediated coacervation of tropoelastin abolishes the critical concentration, accelerates coacervate formation, and facilitates spherule fusion: implications for tropoelastin microassembly. Biomacromolecules. 2008; 9:1739-44

Macdonald, C, Morrow, R, Weiss, A, Bilek, M. Covalent attachment of functional protein to polymer surfaces: a novel one-step dry process. Journal of the Royal Society, Interface / the Royal Society. 2008; 5:663-9

Taddese, S, Weiss, A, Neubert, R, Schmelzer, C. Mapping of macrophage elastase cleavage sites in insoluble human skin elastin. Matrix biology : journal of the International Society for Matrix Biology. 2008; 27:420-8

Dehghani, F, Annabi, N, Valtchev, P, Mithieux, S, Weiss, A, Kazarian, S, Tay, F. Effect of dense gas CO2 on the coacervation of elastin. Biomacromolecules. 2008; 9:1100-1105

2007

Muiznieks, L, Weiss, A. Flexibility in the solution structure of human tropoelastin. Biochemistry. 2007; 46:8196-8205

Dyksterhuis, L, Baldock, C, Lammie, D, Wess, T, Weiss, A. Domains 17-27 of tropoelastin contain key regions of contact for coacervation and contain an unusual turn-containing crosslinking domain. Matrix biology : journal of the International Society for Matrix Biology. 2007; 26:125-35

Clarke, A, Foster, T, Keane, F, Weiss, A. The N-terminal a domain of Staphylococcus aureus fibronectin-binding protein a binds to tropoelastin. BIOCHEMISTRY. 2007; 46:7226-7232

2006

Nicoloff, G, Weiss, A, Iotova, V, Tzaneva, V, Petrova, C, Domuschieva, N, Nikolov, A, Tzvetanov, P, Christova, P. Abnormal levels of serum antielastin antibodies in children with diabetes mellitus type 1. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2006; 54:461-7

Riley, L, Roufogalis, B, Li, G, Weiss, A. A radioassay for synaptic core complex assembly: Screening of herbal extracts for effectors. Analytical biochemistry. 2006; 357:50-7

Clarke, A, Arnspang, E, Mithieux, S, Korkmaz, E, Braet, F, Weiss, A. Tropoelastin Massively Associates during Coacervation To Form Quantized Protein Spheres. Biochemistry. 2006; 45:9989-9996

Lemire, J, Patis, C, Gordon, L, Sandy, J, Toole, B, Weiss, A. Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts. Mechanisms of ageing and development. 2006; 127:660-9

2005

Li, M, Mondrinos, M, Gandhi, M, Ko, F, Weiss, A, Lelkes, P. Electrospun protein fibers as matrices for tissue engineering. Biomaterials. 2005; 26:5999-6008

Rodgers, U, Weiss, A. Cellular interactions with elastin. Pathologie-biologie. 2005; 53:390-8

Cain, S, Baldock, C, Gallagher, J, Morgan, A, Bax, D, Weiss, A, Shuttleworth, C, Kielty, C. Fibrillin-1 interactions with heparin - Implications for microfibril and elastic fiber assembly. Journal of Biological Chemistry. 2005; 280:30526-30537

Clarke, A, Wise, S, Cain, S, Kielty, C, Weiss, A. Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin. Biochemistry. 2005; 44:10271-81

Freeman, L, Lomas, A, Hodson, N, Sherratt, M, Mellody, K, Weiss, A, Shuttleworth, A, Kielty, C. Fibulin-5 interacts with fibrillin-1 molecules and microfibrils. Biochemical Journal. 2005; 388:1-5

Mackay, J, Muiznieks, L, Toonkool, P, Weiss, A. The hydrophobic domain 26 of human tropoelastin is unstructured in solution. Journal of structural biology. 2005; 150:154-62

Wise, S, Mithieux, S, Raftery, M, Weiss, A. Specificity in the coacervation of tropoelastin: solvent exposed lysines. Journal of structural biology. 2005; 149:273-81

Mithieux, S, Wise, S, Raftery, M, Starcher, B, Weiss, A. A model two-component system for studying the architecture of elastin assembly in vitro. Journal of structural biology. 2005; 149:282-9

Gheduzzi, D, Guerra, D, Bochicchio, B, Pepe, A, Tamburro, A, Quaglino, D, Mithieux, S, Weiss, A, Pasquali Ronchetti, I. Heparan sulphate interacts with tropoelastin, with some tropoelastin peptides and is present in human dermis elastic fibers. Matrix biology: journal of the International Society for Matrix Biology. 2005; 24:15-25

Getie, M, Schmelzer, C, Weiss, A, Neubert, R. Complementary mass spectrometric techniques to achieve complete sequence coverage of recombinant human tropoelastin. Rapid Communications in Mass Spectrometry. 2005; 19:2989-2993

Mithieux, S, Weiss, A. Elastin. In: Advances in protein chemistry. United States: Academic Press 2005. p. 437-61.

2004

Reddel, C, Weiss, A. Lamin A expression levels are unperturbed at the normal and mutant alleles but display partial splice site selection in Hutchinson-Gilford progeria syndrome. Journal of medical genetics. 2004. p. 715-717.

Clarke, A, Weiss, A. Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations. European journal of biochemistry / FEBS. 2004; 271:3085-3090

Rock, M, Cain, S, Freeman, L, Morgan, A, Mellody, K, Marson, A, Shuttleworth, C, Weiss, A, Kielty, C. Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link. The Journal of biological chemistry. 2004; 279:23748-23758

Rodgers, U, Weiss, A. Integrin alpha v beta 3 binds a unique non-RGD site near the C-terminus of human tropoelastin. Biochimie. 2004; 86:173-178

2001

Dedic, J, Weiss, A, Katahira, J, Yu, B, Trent, R, Urbán, Z. A novel elastin gene mutation (1281delC) in a family with supravalvular aortic stenosis: a mutation cluster within exon 20. Human mutation. 2001; 17:81