Associate Professor Tailoi Chan-Ling
F13 - Anderson Stuart Building
The University of Sydney NSW 2006 Australia |
|
Dr Chan-Ling has made a sustained contribution to the understanding of glial-vascular biology during normal CNS development as well as key understanding to the disease processes in Retinopathy of Prematurity (the leading cause of infant blindness in the world) animal models of multiple sclerosis, cerebral malaria and inflammation.
Current national competitive grants
|
2008 |
|
|
Isolation and purification of human oligodentrocyte precursor cells |
|
| Multiple Sclerosis Australia Seeding Grant | $15,000 over 1 year |
|
2007 |
|
|
Cellular and molecular mechanisms of human choroidal and retinal vascularisation |
|
| NHMRC Project Grant | $276,750 over 3 years |
|
2006 |
|
|
Senior Research Fellow |
|
| NHMRC Research Fellowship | $626,250 over 5 years |
2008
- Chan-Ling, T, Chu, Y, Baxter, L, Weible Ii, M, Hughes, S. In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae: Differentiation, proliferation, and apoptosis. Glia. 2008; :
- Chan-Ling, T. Vasculogenesis and Angiogenesis in Formation of the Human Retinal Vasculature. In: Retinal and Choroidal Angiogenesis. The Netherlands: Springer Netherlands 2008. p. 119-138.
2007
- Low, R, Jones, A, Houang, M, Newland, L, Morey, A, Chan-Ling, T. Endometriosis of the inguinal region: magnetic resonance imaging (MRI) findings. Australasian radiology. 2007; 51 Suppl:B272-5
- Weible, M, Chan-Ling, T. Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes. Glia. 2007; 55:1156-1168
- Hughes, S, Gardiner, T, Baxter, L, Chan-Ling, T. Changes in pericytes and smooth muscle cells in the kitten model of retinopathy of prematurity: implications for plus disease. Investigative ophthalmology & visual science. 2007; 48:1368-1379
- Chan-Ling, T, Hughes, S, Baxter, L, Rosinova, E, McGregor, I, Morcos, Y, van Nieuwenhuyzen, P, Hu, P. Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: a model for CNS aging. Microcirculation. 2007; 14:63-76
- Pan, H, Grant, M, Sullivan, S, Calzi, S, Sengupta, N, Caballero, S, Chang, K, Baxter, L, Afzal, A, McFarland, E, Chan-Ling, T, Shaw, L. IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007; 104:10595-10600
2006
- Hughes, S, Gardiner, T, Hu, P, Baxter, L, Rosinova, E, Chan-Ling, T. Altered pericyte-endothelial relations in the rat retina during aging: Implications for vessel stability. Neurobiology of Aging. 2006; 27:1838-1847
- Flynn, J, Chan-Ling, T. Retinopathy of prematurity: Two distinct mechanisms that underlie zone 1 and zone 2 disease. American Journal of Ophthalmology. 2006; 142:46-59
- Hunt, N, Golenser, J, Chan-Ling, T, Parekh, S, Rae, C, Potter, S, Medana, I, Miu, J, Ball, H. Immunopathogenesis of cerebral malaria. International journal for parasitology. 2006; 36:569-582
- Potter, S, Chan-Ling, T, Ball, H, Mansour, H, Mitchell, A, Maluish, L, Hunt, N. Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International journal for parasitology. 2006; 36:485-96
- Potter, S, Chan-Ling, T, Rosinova, E, Ball, H, Mitchell, A, Hunt, N. A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of neuroimmunology. 2006; 173:96-107
- Chan-Ling, T, Baxter, L, Afzal, A, Sengupta, N, Caballero, S, Rosinova, E, Grant, M. Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization. American journal of pathology. 2006; 168:1031-44
- Lutty, G, Chan-Ling, T, Phelps, D, Adamis, A, Berns, K, Chan, C, Cole, C, D'Amore, P, Das, A, Deng, W, Dobson, V, Flynn, J, Friedlander, M, Fulton, A, Good, W, Grant, M, Hansen, R, Hauswirth, W, Hardy, R, Hinton, D, Hughes, S, McLeod, D, Palmer, E, Patz, A, Penn, J, Raisler, B, Repka, M, Saint-Geniez, M, Shaw, L, Shima, D, Smith, B, Smith, L, Tahija, S, Tasman, W, Trese, M. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Molecular vision. 2006; 12:532-80
2005
- Chan-Ling, T, Hughes, S. NG2 can be used to identify arteries versus veins enabling the characterization of the different functional roles of arterioles and venules during microvascular network growth and remodeling. Microcirculation (New York, N.Y. : 1994). 2005. p. 539-40; author reply 540-1.
2004
- Chan-Ling, T, Page, M, Gardiner, T, Baxter, L, Rosinova, E, Hughes, S. Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity. American journal of pathology. 2004; 165:1301-13
- Hughes, S, Chan-Ling, T. Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo. Investigative ophthalmology & visual science. 2004; 45:2795-806
- Chan-Ling, T, McLeod, D, Hughes, S, Baxter, L, Chu, Y, Hasegawa, T, Lutty, G. Astrocyte-endothelial cell relationships during human retinal vascular development. Investigative ophthalmology & visual science. 2004; 45:2020-32
2002
- Chan-Ling, T, Gerritsen, M, Hill, C, Kubes, P, Perry, M. Microcirculation down under. Trends In Pharmacological Sciences. 2002; 23 #3:106-108
2001
- Medana, I, Chaudhri, G, Chan-Ling, T, Hunt, N. Central nervous system in cerebral malaria: 'Innocent bystander' or active participant in the induction of immunopathology?. Immunology and cell biology. 2001; 79:101-20
- Medana, I, Chaudhri, G, Chan-Ling, T, Hunt, N. Cenral nervous system in cerebral malaria: 'Innocent bystander' or active participant in the induction of immunopathology?. Immunology and Cell Biology. 2001; 28:1044-1047
- Chu, Y, Hughes, S, Chan-Ling, T. Differentiation & migration of astrocyte precursor cells (APCs) and astrocytes in human fetal retina: relevance to optic nerve coloboma. Faseb Journal. 2001; 10:344-351
- Morcos, Y, Hosie, M, Bauer, H, Chan-Ling, T. Immunolocalization of occludin and claudin-1 to tight junctions in intact CNS vessels of mammalian retina. Journal of Neurocytology. 2001; 16:1120-1124
2000
- Hu, P, Pollard, J, Chan-Ling, T. Breakdown of the Blood-Retinal Barrier Induced by Activated T Cells of Noneural Specificity. American Journal of Pathology. 2000; 156 (4):1139-1149
- Hu, P, Pollard, J, Chan-Ling, T. Breakdown of the blood-retinal barrier induced by activated T cells of nonneural specificity. American Journal of Pathology. 2000; 156:1139-1149
- Medana, I, Chan-Ling, T, Hunt, N. Reactive changes in retinal microglia during fatal murine cerebral malaria. American Journal of Pathology. 2000; 156:1055-1065
- Hughes, S, Chan-Ling, T. Roles of Endothelial Cell Migration & Apoptosis in Vascular Remodeling during Development of the Central Nervous System. Microcirculation (2000). 2000; 7:317-333
- Hughes, S, Yang, H, Chan-Ling, T. Vascularization of the Human Fetal Retina: Roles of Vasculogenesis and Angiogenesis. Investigative Ophthalmology & Visual Science. 2000; 41 (5):1217-1228
