Dr Alexandra Sharland

E:  alexandra.sharland@bosch.org.au T:  +61 2 9351 2897 or +61 2 9515 5416 F:  +61 2 9036 7083 D06 - Blackburn Building The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2008

Laurence, J, Wang, C, Park, E, Buchanan, A, Clouston, A, Allen, R, Mccaughan, G, Bishop, G, Sharland, A. Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection. Transplantation. 2008; 85:1357-1361

Lam, V, Taylor, C, Laurence, J, Wang, C, Sharland, A, McCaughan, G, Hodgkinson, S, Allen, R, Hall, B, Bishop, G. Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: Effect on foxp3 and cytokine expression and graft infiltration. Transplant Immunology. 2008; 19:20-24

2007

Wu, H, Chen, G, Wyburn, K, Yin, J, Bertolino, P, Eris, J, Alexander, S, Sharland, A, Chadban, S. TLR4 activation mediates kidney ischemia/reperfusion injury. The Journal of clinical investigation. 2007; 117:2847-59

Tovey, E, Kemp, A, Almqvist, C, Sharland, A, Marks, G. Do immune responses to inhaled skin flakes modulate the expression of allergic disease?. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2007; 37:1199-1203

2006

Wu, H, Chen, G, Wyburn, K, Afifi, M, Yin, J, Eris, J, Alexander, S, Sharland, A, Chadban, S. TLR4 activation mediates kidney ischemia reperfusion injury. Immunology and Cell Biology. 2006; 84:A29-A29

Benseler, V, Cordoba, S, Wang, C, Zvolynska, A, Sharland, A, Shlitt, H, McCaughan, G, Allen, R, Bishop, G. Microarray analysis of spontaneously tolerant compared to rejecting rat liver allografts. Immunology and Cell Biology. 2006; 84:A31-A32

Laurence, J, Wang, C, Park, T, Vis, A, Allen, R, Bishop, G, Sharland, A. Role of indoleamine dioxygenase (IDO) in rat models of transplantation rejection and tolerance. Immunology and Cell Biology. 2006; 84:A30-A30

Sadeghi, A, Xiao, C, Sharland, A, Allen, R, McCaughan, G, Bishop, G. Cytokine common gamma chain expression and its relation to liver transplant tolerance and rejection in a rat model. Immunology and Cell Biology. 2006; 84:A27-A28

Hing, A, Hicks, M, Gao, L, Faddy, S, Tran, P, Kwan, J, Kesteven, S, Sharland, A, Stewart, G, Macdonald, P. Hormone resuscitation of the brain dead donor and its effects on transplantable organs: Early results. Immunology and Cell Biology. 2006; 84:A20-A20

Lam, V, Laurence, J, Sharland, A, McCaughan, G, Hodgkinson, S, Hall, B, Allen, R, Bishop, A. Induction of long-term cardiac allograft survival using anti-lymphocyte antibodies in the rat model. Immunology and Cell Biology. 2006; 84:A27-A27

Tran, P, Hing, A, Hicks, M, Gao, L, Faddy, S, Kesteven, S, Stewart, G, Macdonald, P, Sharland, A. Expression of NKG2D ligands following brain-death. Immunology and Cell Biology. 2006; 84:A10-A10

Cordoba, S, Wang, C, Sharland, A, McCaughan, G, Allen, R, Bishop, G. Transcriptomics of tolerant and rejecting renal allografts. Immunology and Cell Biology. 2006; 84:A2-A2

Cordoba, S, Wang, C, Williams, R, Li, J, Smit, L, Sharland, A, Allen, R, McCaughan, G, Bishop, A. Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2006; 12:636-43

2005

Cordoba, S, Wang, C, Williams, R, Sharland, A, Allen, R, McCaughan, G, Bishop, G. The STAT-1/IRF-1 signalling pathway and complement cascade are increased in rat liver transplant tolerance identified by meta-analysis of high-throughput screening techniques. Hepatology. 2005; 42:314A-314A

Wu, H, Wyburn, K, Yin, J, Eris, J, Alexander, S, Sharland, A, Chadban, S. Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. Immunology and Cell Biology. 2005; 83:A5-A5

Cordoba, S, Wang, C, Williams, R, Sharland, A, McCaughan, G, Bishop, G. Meta-analysis of transcriptional profiles in three models of transplant tolerance identifies the STAT-1/IRF-1 pathway. Immunology and Cell Biology. 2005; 83:A31-A31

Tran, P, Christiansen, D, Sandrin, M, Sharland, A. Identification and characterisation of porcine ligands for the human NK cell activating receptor NKG2D. Immunology and Cell Biology. 2005; 83:A24-A24

Wu, H, Wynurn, K, Yin, J, Eris, J, Alexander, S, Sharland, A, Chadban, S. Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. American Journal of Transplantation. 2005; 5:269-269

2002

Yan, Y, van der Putten, K, Bowen, D, Painter, D, Kohar, J, Sharland, A, McCaughan, G, Bishop, G. Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with Th2 cytokine expression in long-term accepted grafts. Transplantation. 2002; 73:1123-30

Sharland, A, Patel, A, Lee, J, Cestra, A, Saidman, S, Waneck, G. Genetically modified HLA class I molecules able to inhibit human NK cells without provoking alloreactive CD8+ CTLs. Journal of immunology (Baltimore, Md. : 1950). 2002; 168:3266-74

Bishop, G, Wang, C, Sharland, A, McCaughan, G. Spontaneous acceptance of liver transplants in rodents: evidance that liver leucocytes induce recipient T-cell death by neglect. Immunology And Cell Biology. 2002; 80:93-100

Bishop, G, Sharland, A, McCaughan, G, Wang, C. Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunology And Cell Biology. 2002; 80:93-100

2001

Yan, Y, Shastry, S, Richards, C, Wang, C, Bowen, D, Sharland, A, Painter, D, McCaughan, G, Bishop, G. Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of immunology (Baltimore, Md. : 1950). 2001; 166:5258-64

2000

McCaughan, G, Gorrell, M, Bishop, G, Abbott, C, Shackel, N, McGuinness, P, Levy, M, Sharland, A, Bowen, D, Yu, D, Slaitini, L, Church, W, Napoli, J. Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews. 2000; 174:172-191