Clinical Professor Steve Chadban

T:  +61 2 9515 6600 F:  +61 2 9515 6329 C39 - Royal Prince Alfred Hospital The University of Sydney NSW 2006 Australia

• Research interests
• Competitive grants
• Publications

Research interests

Current national competitive grants

Publications

2010

Tong, A, Howard, K, Jan, S, Cass, A, Rose, J, Chadban, S, Allen, R, Craig, J. Community preferences for the allocation of solid organs for transplantation: a systematic review. Transplantation. 2010; 89:796-805

Pilmore, H, Dent, H, Chang, S, McDonald, S, Chadban, S. Reduction in Cardiovascular Death After Kidney Transplantation. Transplantation. 2010; 89:851-7

Howard, K, White, S, Salkeld, G, McDonald, S, Craig, J, Chadban, S, Cass, A. Cost-Effectiveness of Screening and Optimal Management for Diabetes, Hypertension, and Chronic Kidney Disease: A Modeled Analysis. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2010; 13:196-208

2009

White, S, Polkinghorne, K, Cass, A, Shaw, J, Atkins, R, Chadban, S. Alcohol consumption and 5-year onset of chronic kidney disease: the AusDiab study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009; 24:2464-72

White, S, Perkovic, V, Cass, A, Chang, C, Poulter, N, Spector, T, Haysom, L, Craig, J, Salmi, I, Chadban, S, Huxley, R. Is Low Birth Weight an Antecedent of CKD in Later Life? A Systematic Review of Observational Studies. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2009; 54:248-61

Tong, A, Sainsbury, P, Chadban, S, Walker, R, Harris, D, Carter, S, Hall, B, Hawley, C, Craig, J. Patients' experiences and perspectives of living with CKD. American Journal of Kidney Diseases. 2009; 53:689-700

Howard, K, Salkeld, G, White, S, McDonald, S, Chadban, S, Craig, J, Cass, A. The cost-effectiveness of increasing kidney transplantation and home-based dialysis. Nephrology (Carlton, Vic.). 2009; 14:123-32

Fry, K, Patwardhan, A, Ryan, C, Trevillian, P, Chadban, S, Westgarth, F, Chan, M. Development of evidence-based guidelines for the nutritional management of adult kidney transplant recipients. Journal of Renal Nutrition. 2009; 19:101-104

2008

Wu, H, Craft, M, Wang, P, Wyburn, K, Chen, G, Ma, J, Hambly, B, Chadban, S. IL-18 Contributes to Renal Damage after Ischemia-Reperfusion. Journal of the American Society of Nephrology : JASN. 2008; 19:2331-41

Ko, H, Hambly, B, Eris, J, Levidiotis, V, Wyburn, K, Wu, H, Chadban, S, Yin, J. Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. Transplant immunology. 2008; 20:99-105

Tong, A, Sainsbury, P, Carter, S, Hall, B, Harris, D, Walker, R, Hawley, C, Chadban, S, Craig, J. Patients' priorities for health research: focus group study of patients with chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008; 23:3206-14

Chadban, S, Morris, R, Hirsch, H, Bunnapradist, S, Arns, W, Budde, K. Immunosuppression in renal transplantation: some aspects for the modern era. Transplantation reviews (Orlando, Fla.). 2008; 22:241-51

White, S, McGeechan, K, Jones, M, Cass, A, Chadban, S, Polkinghorne, K, Perkovic, V, Roderick, P. Socioeconomic Disadvantage and Kidney Disease in the United States, Australia, and Thailand. American journal of public health. 2008; 98:1306-13

White, S, Chadban, S, Jan, S, Chapman, J, Cass, A. How can we achieve global equity in provision of renal replacement therapy?. Bulletin of the World Health Organization. 2008; 86:229-237

White, S, Polkinghorne, K, Cass, A, Shaw, J, Atkins, R, Chadban, S. Limited knowledge of kidney disease in a survey of AusDiab study participants. Medical Journal of Australia. 2008; 188:204-208

Perkovic, V, Cass, A, Patel, A, Suriyawongpaisal, P, Barzi, F, Chadban, S, Macmahon, S, Neal, B. High prevalence of chronic kidney disease in Thailand. Kidney international. 2008; 73:473-9

Perkovic, V, Cass, A, Patel, A, Suriyawongpaisal, P, Barzi, F, Chadban, S, MacMahon, S, Neal, B. High prevalence of chronic kidney disease in Thailand. Kidney International. 2008; 73:473-479

Kondalsamy-Chennakesavan, S, Hoy, W, Wang, Z, Briganti, E, Polkinghorne, K, Chadban, S, Shaw, J, , A. Anthropometric measurements of Australian Aboriginal adults living in remote areas: comparison with nationally representative findings. American journal of human biology : the official journal of the Human Biology Council. 2008; 20:317-324

Howard, K, Salkeld, G, White, S, Chadban, S, Craig, J, Cass, A, McDonald, S, Perkovic, V. Cost effectiveness of screening for the early diagnosis and treatment of risk factors for chronic kidney disease: a Markov Monte Carlo microsimulation using marck-E (model for the assessment of risk factors for chronic kidney disease - economics). Australia and New Zealand Society of Nephrology Annual Scientific Conference. 2008; Melbourne, Australia,14-19 August; 2006

Chadban, S. New-onset diabetes after transplantation-should it be a factor in choosing an immunosuppressant regimen for kidney transplant recipients. Nephrology Dialysis Transplantation. 2008; 23:1816-1818

2007

Wu, H, Chen, G, Wyburn, K, Yin, J, Bertolino, P, Eris, J, Alexander, S, Sharland, A, Chadban, S. TLR4 activation mediates kidney ischemia/reperfusion injury. The Journal of clinical investigation. 2007; 117:2847-59

Chang, S, Russ, G, Chadban, S, Campbell, S, McDonald, S. Trends in Kidney Transplantation in Australia and New Zealand, 1993-2004. Transplantation. 2007; 84:611-618

Hoy, W, Kondalsamy-Chennakesavan, S, Wang, Z, Briganti, E, Shaw, J, Polkinghorne, K, Chadban, S, , A. Quantifying the excess risk for proteinuria, hypertension and diabetes in Australian Aborigines: comparison of profiles in three remote communities in the Northern Territory with those in the AusDiab study. Australian and New Zealand journal of public health. 2007; 31:177-183

Yi, S, Wang, Y, Chandra, A, O'Hara, J, Wu, J, Ouyang, L, Burgess, J, Hawthorne, W, Wu, H, Chadban, S, O'Connell, P. Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation. 2007; 83:615-623

Killen, J, Chadban, S. Antithymocyte globulin versus basiliximab in renal transplantation. The New England journal of medicine. 2007. p. 634; author reply 634-5.

Chadban, S, Baines, L, Polkinghorne, K, Jefferys, A, Dogra, S, Kanganas, C, Irish, A, Eris, J, Walker, R. Anemia after kidney transplantation is not completely explained by reduced kidney function. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2007; 49:301-309

McClintock, C, Cass, A, Chadban, S. How to treat: Chronic Kidney Disease. Australian Doctor. 2007; 0:19-23

McDonald, S, Russ, G, Campbell, S, Chadban, S. Kidney transplant rejection in Australia and New Zealand: Relationships between rejection and graft outcome. AMERICAN JOURNAL OF TRANSPLANTATION. 2007; 7:1201-1208

2006

Wyburn, K, Wu, H, Chen, G, Yin, J, Eris, J, Chadban, S. Interleukin-18 affects local cytokine expression but does not impact on the development of kidney allograft rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2006; 6:2612-21

Ko, H, Yin, J, Hambly, B, Wyburn, K, Wu, H, Chadban, S, Eris, J. Rapamycin and Sanglifehrin A can inhibit interleukin-18 production from dendritic cells in vitro and in vivo. Immunology and Cell Biology. 2006; 84:A26-A26

Yin, J, Ko, H, Wyburn, K, Wu, H, Hambly, B, Chadban, S, Eris, J. The role of IL-12 family cytokines in chronic allograft nephropathy. Immunology and Cell Biology. 2006; 84:A12-A12

Chadban, S, Campbell, S, Russ, G, Walker, R, Chapman, J, Pussell, B, Trevillian, P, Ierino, F, Thompson, N, Hutchison, B, Irish, A. A one-year, randomised, open label, parallel group study to investigate the safety and efficacy of enteric-coated Mycophenolate sodium (EC-MPS) in combination with full dose or reduced dose cyclosporine microemulsion (CSA-ME), basiliximab and steroids in de novo kidney transplantation. Immunology and Cell Biology. 2006; 84:A6-A6

Eykman, L, Mawson, J, Robertson, P, Chadban, S, Allen, R. The monetary cost of living kidney donation. Immunology and Cell Biology. 2006; 84:A4-A5

Nguyen, D, Ping, F, Mu, W, Hill, P, Atkins, R, Chadban, S. Macrophage accumulation in human progressive diabetic nephropathy. Nephrology (Carlton, Vic.). 2006; 11:226-31

Wu, H, Chen, G, Wyburn, K, Afifi, M, Yin, J, Eris, J, Alexander, S, Sharland, A, Chadban, S. TLR4 activation mediates kidney ischemia reperfusion injury. Immunology and Cell Biology. 2006; 84:A29-A29

Polkinghorne, K, Su, Q, Chadban, S, Shaw, J, Zimmet, P, Atkins, R. Population prevalence of albuminuria in the Australian Diabetes, Obesity, and Lifestyle (AusDiab) study: immunonephelometry compared with high-performance liquid chromatography. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2006; 47:604-13

Büchler, M, Chadban, S, Cole, E, Midtvedt, K, Thervet, E, Prestele, H, Keown, P. Evolution of the absorption profile of cyclosporine A in renal transplant recipients: a longitudinal study of the de novo and maintenance phases. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006; 21:197-202

2005

Wyburn, K, Jose, M, Wu, H, Atkins, R, Chadban, S. The role of macrophages in allograft rejection. Transplantation. 2005; 80:1641-7

Verran, D, Robertson, A, Chapman, J, Chadban, S. Non-heart-beating donors. Nephrology (Carlton, Vic.). 2005; 10 Suppl 4:S116-9

Blazik, M, Hutchinson, P, Jose, M, Polkinghorne, K, Holdsworth, S, Atkins, R, Chadban, S. Leukocyte phenotype and function predicts infection risk in renal transplant recipients. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association. 2005; 20:2226-30

Wu, H, Wyburn, K, Yin, J, Eris, J, Alexander, S, Sharland, A, Chadban, S. Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. Immunology and Cell Biology. 2005; 83:A5-A5

Benseler, V, Bishop, A, Chng, K, Watson, J, Wang, C, Dahlke, M, Koutalistras, N, Watts, A, Hawthorne, W, McKenzie, P, Hennessy, A, Pleass, H, Chadban, S, Schlitt, H, McCaughan, G, Allen, R. Development of a primate model to evaluate strategies to achieve long term renal allograft acceptance. Immunology and Cell Biology. 2005; 83:A26-A26

Chadban, S, Ierino, F. Welcome to the era of CKD and the eGFR. Estimating glomerular filtration rate using a simplified formula will lead to a vast increase in detection of chronic kidney disease in Australia. Medical Journal of Australia. 2005; 183:117-8

Yu, R, Chadban, S, Svara, F, Sen, S, Eris, J. Two cases of delayed cyclosporin absorption leading to CsA exposure higher than that predicted by C2 monitoring alone. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association. 2005; 20:1745-7

Ko, H, Yin, J, Hambly, B, Wyburn, K, Wu, H, Chadban, S, Eris, J. Immunosuppressants rapamycin and sanglifehrin A inhibit bioactive IL-18 production by dendritic. Immunology and Cell Biology. 2005; 83:A32-A32

Yin, J, Wyburn, K, Wu, H, Chadban, S, Eris, J. The role of IL-18 and IL-12 family in chronic allograft nephropathy. Immunology and Cell Biology. 2005; 83:A25-A25

Wu, H, Wynurn, K, Yin, J, Eris, J, Alexander, S, Sharland, A, Chadban, S. Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. American Journal of Transplantation. 2005; 5:269-269

Wyburn, K, Wu, H, Yin, J, Jose, M, Eris, J, Chadban, S. Interleukin-18 is elevated in experimental renal allograft rejection. American Journal of Transplantation. 2005; 5:303-303

Buchler, M, Chadban, S, Cole, E, Midtvedt, K, Thervet, E, Prestele, H, Keown, P. Pharmacokinetics of cyclosporine-microemulsion after renal transplantation: How long does C2-monitoring add value?. American Journal of Transplantation. 2005; 5:461-461

Wyburn, K, Wu, H, Yin, J, Jose, M, Eris, J, Chadban, S. Macrophage-derived interleukin-18 in experimental renal allograft rejection. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association. 2005; 20:699-706

Stefoni, S, Midtved, K, Cole, E, Thervet, E, Cockfield, S, Buchler, M, Toselli, L, Pallardo, L, Schena, F, Pilmore, H, Kessler, M, Chadban, S, Carreno, C. Efficacy and safety outcomes among de novo renal transplant recipients managed by C-2 monitoring of cyclosporine A microemulsion: Results of a 12-month, randomized, multicenter study. Transplantation. 2005; 79:577-583

Kusyk, T, Verran, D, Stewart, G, Ryan, B, Fisher, J, Tsacalos, K, Chadban, S, Eris, J. Increased risk of hemorrhagic complications in renal allograft recipients receiving systemic heparin early posttransplantation. Transplantation proceedings. 2005; 37:1026-8

Chadban, S, Atkins, R. Glomerulonephritis. Lancet. 2005; 365:1797-806

White, S, Cass, A, Atkins, R, Chadban, S. Chronic kidney disease in the general population. Advances in chronic kidney disease. 2005; 12:5-13

2004

Flanc, R, Roberts, M, Strippoli, G, Chadban, S, Kerr, P, Atkins, R. Treatment of diffuse proliferative lupus nephritis: a meta-analysis of randomized controlled trials. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2004; 43:197-208

Flanc, R, Roberts, M, Strippoli, G, Chadban, S, Kerr, P, Atkins, R. Treatment for lupus nephritis. Cochrane database of systematic reviews (Online : Update Software). 2004; 1:CD002922

2003

Jose, M, Ikezumi, Y, Van Rooijen, N, Atkins, R, Chadban, S. Macrophages act as effectors of tissue damage in acute renal allograft rejection. Transplantation. 2003; 76 (7):1015-1022

Atkins, R, Briganti, E, Zimmet, P, Chadban, S. Association between albuminuria and proteinuria in the general population: the AusDiab study. Nephrology Dialysis Transplantation. 2003; 18:2170-2174

Jose, M, Le Meur, Y, Atkins, R, Chadban, S. Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection. American Journal Of Transplantation. 2003; 3:294-300

Thurvet, E, Chadban, S, 11 Researchers from, P. Clinical outcomes during the first three months posttransplant in renal allograft recipients managed by C2 monitoring of cyclosporine microemulsion. Transplantation. 2003; 76 (6):903-908

Briganti, E, Shaw, J, Chadban, S, Zimmet, P, Welborn, T, Mcneil, J, Atkins, R. Untreated hypertension among Australian adults: the 1999-2000 Australian diabetes, obesity and lifestyle study (AusDiab). Medical Journal Of Australia. 2003; 179:135-139

Smith, G, Trauer, T, Kerr, P, Chadban, S. Prospective psychosocial monitoring of living kiney donors using the SF-36 health survey. Transplantation. 2003; 76:807-809

Chadban, S, Briganti, E, Kerr, P, Dunstan, D, Welborn, T, Zimmet, P, Atkins, R. Prevalence of kidney damage in Australian adults: the AusDiab Kidney Study. Journal Of The American Society Of Nephrology. 2003; 14:S131-S138

Russ, G, Campbell, S, Chadban, S, Eris, J, O'connell, P, Pussell, B, Walker, R. Reduced and standard target concentration tacrolimus with sirolimus in renal allograft recipients. Transplantation Proceedings. 2003; 35 (Suppl 3):115S-117S